Fig. 1From: Glial interference: impact of type I interferon in neurodegenerative diseasesSchematic illustrating the central role of interferon-response microglia (IRM) in pathophysiology of several prominent neurodegenerative disorders. This unique cell type arises through distinct etiologies in each disease, but pathological sequelae resulting from their activation follow the common themes of damage to neurons (synapse alterations and neuronal loss) and neuroinflammation. NA+ amyloid = nucleic acid-containing amyloid. Created with BioRender.comBack to article page