Table 1 Demographic and biomarker information of the TRIAD cohort by clinical and biomarker-defined groups

Age, years

23.3 (1.8)

71.0 (7.4)

72.2 (7.5)

72.2 (6.1)

64.6 (7.1)

70.5 (9.5)

62.4 (6.2)

 < 0.0001*

Female, n (%)

14 (63)

34 (63)

17 (65)

9 (47)

8 (42)

7 (43)

6 (66)

0.44

Education, years

16.7 (1.5)

14.9 (3.6)

14.4 (2.7)

15.8 (2.8)

15.4 (3.1)

13.7 (4.0)

14.4 (4.0)

0.08

APOE-ε4 carriers, n (%)

6 (27)

17 (31)

8 (30)

12 (63)

13 (72)

4 (26)

1 (11)

0.002*

MMSE

29.7 (0.5)

29.1 (1.0)

29.3 (0.8)

27.9 (1.8)

20.0 (6.3)

26.7 (2.8)

26.0 (7.3)

 < 0.0001*

Aß PET (SUVR)

1.18 (0.06)

1.26 (0.10)

1.96 (0.42)

2.40 (0.42)

2.35 (0.44)

1.33 (0.12)

1.15 (0.08)

 < 0.0001*

Tau PET (SUVR)

0.82 (0.08)

0.91 (0.10)

1.00 (0.15)

1.56 (0.45)

2.09 (0.55)

1.11 (0.65)

0.79 (0.10)

 < 0.0001*

p-Tau181 (fmol/mL)

0.86 (0.25)

1.15 (0.33)

1.41 (0.49)

1.79 (0.71)

1.74 (0.69)

1.48 (0.95)

0.98 (0.43)

 < 0.0001*

p-Tau199 (fmol/mL)

0.17 (0.06)

0.24 (0.05)

0.29 (0.08)

0.35 (0.12)

0.43 (0.17)

0.32 (0.24)

0.24 (0.07)

 < 0.0001*

p-Tau202 (fmol/mL)

0.06 (0.02)

0.09 (0.03)

0.10 (0.03)

0.13 (0.06)

0.15 (0.05)

0.12 (0.06)

0.09 (0.04)

 < 0.0001*

p-Tau205 (fmol/mL)

0.01 (0.004)

0.02 (0.01)

0.03 (0.01)

0.08 (0.07)

0.11 (0.05)

0.05 (0.09)

0.02 (0.009)

 < 0.0001*

p-Tau217 (fmol/mL)

0.04 (0.01)

0.08 (0.04)

0.20 (0.13)

0.40 (0.25)

0.54 (0.31)

0.25 (0.43)

0.12 (0.17)

 < 0.0001*

p-Tau231 (fmol/mL)

0.02 (0.02)

0.07 (0.07)

0.29 (0.29)

0.50 (0.26)

0.60 (0.38)

0.31 (0.53)

0.12 (0.24)

 < 0.0001*

p-Tau396 (fmol/mL)

0.03 (0.01)

0.05 (0.02)

0.06 (0.03)

0.07 (0.02)

0.06 (0.03)

0.06 (0.03)

0.04 (0.02)

 < 0.0001*