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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Fig. 2

The microglia subtype LADAM is observed in the Tau4RΔK-AP mice in the 12-month-old cortex. A UMAP plot showing microglia clusters—Homeostatic, DAM1, DAM2, EADAM, and LADAM, across 4 genotypes in 12-month-old cortex (n = 3/genotype), and pie graphs showing the distribution of 4 microglia clusters across genotypes (n = 3/genotype). B Violin plots showing top cluster genes of 3 microglia clusters. C Bar graphs showing the distribution of 5 microglia clusters within each genotype (n = 3/genotype). Note the significant increase in the LADAM cluster in Tau4RΔK-AP mice. D Regulon analysis with SCENIC [40], showing key regulons in each microglia cluster. E GO analysis of top differential genes reveals a biological function in each microglia cluster. F Heatmap showing expression of DAM-enriched genes across genotypes. G Heatmap showing expression of LADAM-enriched genes across genotypes. * P < 0.05, ** P < 0.005, *** P < 0.0001

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Molecular Neurodegeneration

ISSN: 1750-1326