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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Fig. 4

Analysis of EADAM and LADAM markers in other mouse models of neurodegenerative disease. A UMAP plot showing microglia clusters in the 6 and 12-month-old cortex (all genotypes) (Fig. 3A left panel). B UMAP plot showing microglia clusters in CamKIICreERT2;Tardbplox/lox (TDP43 KO), 4-OHT induction at 6 months and collected at 9 months. N = 2. C UMAP plot showing microglia clusters in CamKIICreERT2;Tardbplox/lox (TDP43 KO), 4-OHT induction at 12 months and collected at 15 months. N = 2. D Heatmap plot showing expression of EADAM-enriched genes across AD genotypes and in TDP43 KO. E Heatmap plot showing expression of LADAM-enriched genes across AD genotypes and in TDP43 KO

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Molecular Neurodegeneration

ISSN: 1750-1326