Fig. 5
6-month-old EADAM at and 12-month-old LADAM clusters in Tau4RΔK-AP mice resemble microglial subtypes seen in snRNA-Seq from AD samples. A UMAP plot showing microglia clusters in the 6 and 12-month-old cortex (all genotypes) from Fig. 3A. EADAM and LADAM-enriched gene homologs were studied in human snRNA-Seq. B Schematic showing snRNA-Seq from human postmortem samples, primary age-related tauopathy (PART) entorhinal cortex (ERC), superior frontal gyrus (SFG); Stage 2 ERC, SFG; Stage 4 SFG; Stage 6 SFG. C UMAP plot showing the distribution of subsetted microglia from human snRNA-Seq. N = 2 (PART, 1102 cells), n = 2 (Stage 2 SFG, 750 cells), n = 2 (Stage 2 ERC, 2645 cells), n = 4 (Stage 4 and 6 SFG, 1692 cells). D Violin plots showing expression of EADAM-like interferon family members. E Violin plots showing expressions of LADAM-like MHC and S100 family members. F UMAP plot showing microglia from human snRNA-Seq dataset from Morabito et al., 2021. N = 7 (Control, 1384 cells), n = 11 (AD, 2742 cells). G Violin plots showing IFN, MHC, and S100 family members in the dataset from Morabito et al., 2021