Fig. 1
From: Alzheimer’s disease: targeting the peripheral circulation
The potential mechanisms of whole blood exchange as an intervention for Alzheimer’s disease. A) Young wild-type (Wt) mice have abundant young immune cells and protective factors but fewer harmful factors and no Aβ in the blood. B) Elderly transgenic mice with Alzheimer’s disease (AD) have fewer young immune cells and protective factors and abundant harmful factors and Aβ in the blood. C) Schematic diagram of whole blood exchange. D) Transplantation of blood from young Wt mice into elderly AD mice could enhance the peripheral clearance of Aβ, increase the number of young immune cells and protective factors, reduce the number of harmful factors, and ultimately alleviate brain Aβ deposition. E) Key for the symbols used in this figure