Fig. 3
From: Common mouse models of tauopathy reflect early but not late human disease
PTMs in insoluble Tau occur in a sequential manner during disease progression in mouse models. A, B A summary of PTMs identified in cortical insoluble Tau at the last time point of the P301S (A) and the P301L (B) models. PTMs represented are found in \(\ge\) 50% of the biological replicates. C, D A sequential addition of PTMs in the cortex during disease progression is observed with unbiased Euclidean distance hierarchical clustering of Tau PTM data (binary—presence/absence) from the P301S (C) and the P301L (D) models. PTMs used for clustering were identified in ≥ 50% of the biological replicates. Grey squares indicate the presence of a PTM. Annotated clusters represent PTMs identified at all time points (blue), PTMs appearing concomitant with tangle formation (orange), and PTMs that appear after tangle formation (magenta)