Fig. 5
From: Common mouse models of tauopathy reflect early but not late human disease
Pathological insoluble Tau of human P301L patients exhibits only minimal modification (Frontal cortex, BA46). A, B Absolute amount of insoluble (A) and soluble (B) Tau from P301L patients and healthy controls. C Euclidean distance hierarchical clustering of binary PTMs data from insoluble Tau derived from P301L patients and healthy controls in comparison to the cortex in the end stage of the P301S and P301L mouse models. PTMs used for clustering were identified in ≥ 50% of the human biological replicates or were present in one of the mouse models at the last time point. Grey squares indicate the presence of a PTM. D Euclidean hierarchical clustering of relative amounts of unmodified FLEX-peptide of insoluble Tau derived from P301L patients and healthy controls in comparison to the cortex in the end stage of the P301S and P301L mouse models. E Relative amounts of unmodified FLEX-peptides from insoluble Tau derived from P301L patients and healthy controls ordered from N- to C-terminus controls in comparison to the cortex in the end stage of the P301S and P301L mouse models