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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Common mouse models of tauopathy reflect early but not late human disease

Fig. 6

Comparison of the modification landscape of murine and human insoluble Tau. Insoluble Tau of the cortex of P301S and P301L mouse models shows a similar phosphorylation pattern to early stages of human AD and human P301L carriers (human AD data is adapted from [20]). Tau ubiquitination and acetylation of human late-stage AD is not represented in both mouse models. The represented modification sites are documented in table S2. Transverse lines indicate the absence of two N-terminal repeat regions in the human Tau transgene of both mouse models as both models only overexpress 0N4R Tau

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