Fig. 1

Main differences between PLCγ2 p.P522R-carriers and non-carriers in Cohort I. A Major differences in absolute immune cell counts between carriers and non-carriers. B Major differences in activation marker expression between carriers and non-carriers. Mean fluorescence intensity (MFI) was corrected by subtraction of background signal on a negative reference population. Differences between cohorts were determined using the Mann-Whitney U test. Green circles indicate p.P522R-carriers, and black circles indicate non-carriers. Centenarian data points are indicated in the graphs as an open red circle. Grey boxes indicate the 95%CI and dashed lines indicate the median cell count or MFI from a younger reference cohort (n = 25, average age: 31 years old), whose data was collected in the same laboratory, using identical methods and equipment. N = 31, * p < 0.05, ** p < 0.01