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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system

Fig. 2

PLCγ2 expression in different populations of circulating immune cells. A PLCγ2 expression measured as mean fluorescence intensity (MFI) and corrected for background signal by subtracting the MFI signal of a negative reference population (T cells) of the total cohort (irrespective of p.P522R-carriership). N = 31. B PLCγ2 expression on B-cell and myeloid cell subsets in p.P522R-carriers (green) and non-carriers (grey). Dashed lines represent the median (min-max) of PLCγ2 expression of B cells of the total cohort. CPLCγ2 expression on B-cell and myeloid cell subsets between carriers (green) and non-carriers (black). The median of each subset is plotted, medians of the same subset are connected with lines. % increase in PLCγ2 expression in carriers vs non-carriers is indicated behind each population in the legend. Differences were evaluated with Mann-Whitney U test. MBC; memory B cell, IgMD+ MBC; unswitched memory B cell, Pre-GC; pre-Germinal Center B cells, PC; plasma cells, NK cells; Natural Killer cells. * p < 0.05

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