Fig. 1
Insights from New in vivo Models of TREM2 Variants. A. Trem2R47H mouse models created through CRISPR/Cas9 and through bacterial artificial chromosome technology and their effects on Trem2 mRNA levels and protein levels if assessed. Highlight of plaque and microglia interactions in Trem2R47H mouse models. B. The H157Y variant in a mouse model of amyloidosis increased levels of soluble Trem2 and increased Aβ clearance. During late amyloidosis (8.5 mo-old), Qiao et al. observed a reduction in amyloid burden, dystrophic neurites, and gliosis. This was paralleled with enhanced synaptic plasticity