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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Fig. 3

Bace1 deficiency in adult mice increases Clu and Cxcl14 gene expression in reactive astrocytes. A Transcriptomic analysis was performed on single-cell RNA-seq of astrocytes sorted from 14-month-old 5xFAD;Bace1fl/fl and 5xFAD;Bace1fl/fl;UBC-creER mice (N = 3, per genotype). Violin plot of genes showed high expression of Clu and Cxcl14 (log2 fold change expression) in 5xFAD;Bace1fl/fl; UBC-creER compared 5xFAD;Bace1fl/fl reactive astrocyte clusters. B Distribution of cells highly expressing Clu and Cxcl14 with indicated log2 fold change scaling based on UMAP clustering of astrocytes

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