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  1. An early substantial loss of basal forebrain cholinergic neurons (BFCNs) is a constant feature of Alzheimer’s disease (AD) and is associated with deficits in spatial learning and memory. Induced pluripotent st...

    Authors: Lishu Duan, Bula J Bhattacharyya, Abdelhak Belmadani, Liuliu Pan, Richard J Miller and John A Kessler

    Citation: Molecular Neurodegeneration 2014 9:3

    Content type: Research article

    Published on:

  2. The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for Alzheimer’s disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a soluble oligomeric form (oAβ), is consid...

    Authors: Leon M Tai, Shipra Mehra, Varsha Shete, Steve Estus, G William Rebeck, Guojun Bu and Mary Jo LaDu

    Citation: Molecular Neurodegeneration 2014 9:2

    Content type: Review

    Published on:

  3. BACE1 is one of the two enzymes that cleave amyloid precursor protein to generate Alzheimer's disease (AD) beta amyloid peptides. It is widely believed that BACE1 initiates APP processing in endosomes, and in ...

    Authors: Virginie Buggia-Prévot, Celia G Fernandez, Sean Riordan, Kulandaivelu S Vetrivel, Jelita Roseman, Jack Waters, Vytautas P Bindokas, Robert Vassar and Gopal Thinakaran

    Citation: Molecular Neurodegeneration 2014 9:1

    Content type: Research article

    Published on:

  4. The high affinity tyrosine kinase receptor, TrkB, is the primary receptor for brain derived neurotrophic factor (BDNF) and plays an important role in development, maintenance and plasticity of the striatal out...

    Authors: Ellen M Unterwald, Michelle E Page, Timothy B Brown, Jonathan S Miller, Marta Ruiz, Karen A Pescatore, Baoji Xu, Louis French Reichardt, Joel Beverley, Bin Tang, Heinz Steiner, Elizabeth A Thomas and Michelle E Ehrlich

    Citation: Molecular Neurodegeneration 2013 8:47

    Content type: Research article

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  5. Mutations in the gene encoding superoxide dismutase 1 (SOD1) account for about 20% of the cases of familial amyotrophic lateral sclerosis (fALS). It is well established that mutations in SOD1, associated with ...

    Authors: David A Qualls, Mercedes Prudencio, Brittany LT Roberts, Keith Crosby, Hilda Brown and David R Borchelt

    Citation: Molecular Neurodegeneration 2013 8:46

    Content type: Research article

    Published on:

  6. Mitochondrial impairment has been implicated in the pathogenesis of Huntington’s disease (HD). However, how mutant huntingtin impairs mitochondrial function and thus contributes to HD has not been fully elucid...

    Authors: Rodrigo A Quintanilla, Youngnam N Jin, Rommy von Bernhardi and Gail VW Johnson

    Citation: Molecular Neurodegeneration 2013 8:45

    Content type: Research article

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  7. Alpha-synuclein is a key protein implicated in the pathogenesis of Parkinson's disease (PD). It is the main component of the Lewy bodies, a cardinal neuropathological feature in the disease. In addition, whole...

    Authors: Marusela Oliveras-Salvá, Anke Van der Perren, Nicolas Casadei, Stijn Stroobants, Silke Nuber, Rudi D’Hooge, Chris Van den Haute and Veerle Baekelandt

    Citation: Molecular Neurodegeneration 2013 8:44

    Content type: Research article

    Published on:

  8. Mutations in the Cu/Zn superoxide dismutase gene (SOD1) are responsible for 20% of familial forms of amyotrophic lateral sclerosis (ALS), and mutant SOD1 has been shown to have increased surface hydrophobicity in...

    Authors: Pei-Yi Lin, Sharotka M Simon, Won Kyun Koh, Oluwarotimi Folorunso, C Samuel Umbaugh and Anson Pierce

    Citation: Molecular Neurodegeneration 2013 8:43

    Content type: Research article

    Published on:

  9. Spinocerebellar ataxia type 7 (SCA7) is caused by a toxic polyglutamine (polyQ) expansion in the N-terminus of the protein ataxin-7. Ataxin-7 has a known function in the histone acetylase complex, Spt/Ada/Gcn5...

    Authors: Carlotta E Duncan, Mahru C An, Theodora Papanikolaou, Caitlin Rugani, Cathy Vitelli and Lisa M Ellerby

    Citation: Molecular Neurodegeneration 2013 8:42

    Content type: Research article

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  10. Alzheimer’s disease (AD) is the most common form of dementia. At the diagnostic stage, the AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular neurofibrillary tangles ...

    Authors: Sonia Do Carmo and A Claudio Cuello

    Citation: Molecular Neurodegeneration 2013 8:37

    Content type: Review

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  11. The aging process correlates with a progressive failure in the normal cellular and organ functioning; these alterations are aggravated in Alzheimer’s disease (AD). In both aging and AD there is a general decre...

    Authors: Fernanda Marques, João Carlos Sousa, Nuno Sousa and Joana Almeida Palha

    Citation: Molecular Neurodegeneration 2013 8:38

    Content type: Review

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  12. Alzheimer’s disease (AD) is the most common form of dementia, afflicting more than 30 million people worldwide. Currently, there is no cure or way to prevent this devastating disease. Extracellular plaques, co...

    Authors: Cynthia A Lemere

    Citation: Molecular Neurodegeneration 2013 8:36

    Content type: Review

    Published on:

  13. Alzheimer’s disease (AD) is neuropathologically characterized by the combined occurrence of extracellular β-amyloid plaques and intracellular neurofibrillary tangles in the brain. While plaques contain aggrega...

    Authors: Jochen Walter and Gerhild van Echten-Deckert

    Citation: Molecular Neurodegeneration 2013 8:34

    Content type: Review

    Published on:

  14. Alzheimer’s disease (AD) is characterized by progressive memory loss and impaired cognitive function. Early-onset familial forms of the disease (FAD) are caused by inheritance of mutant genes encoding presenil...

    Authors: Karthikeyan Veeraraghavalu, Se Hoon Choi, Xiaoqiong Zhang and Sangram S Sisodia

    Citation: Molecular Neurodegeneration 2013 8:41

    Content type: Research article

    Published on:

  15. Increasing evidence indicates that neuroinflammation is a critical factor contributing to the progression of various neurodegenerative diseases. The IKK/NF-κB signalling system is a central regulator of inflam...

    Authors: Ayesha Maqbool, Michael Lattke, Thomas Wirth and Bernd Baumann

    Citation: Molecular Neurodegeneration 2013 8:40

    Content type: Research article

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  16. Authors: Inger Lauritzen, Raphaelle Pardossi-Piquard, Charlotte Druon, Elizabeth Brigham, Daniel Abraham, Sébatien Ranaldi, Linda Chami, Julie Dunys and Fréderic Checler

    Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P63

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  17. Authors: Eric Duplan, Jean Sévalle, Julien Viotti, Thomas Goiran, Charlotte Bauer, Paul Renbaum, Ephrat Levy-Lahad, Clément A Gautier, Olga Corti, Nathalie Leroudier, Frédéric Checler and Cristine Alves da Costa

    Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P56

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  18. Epidemiological and molecular findings suggest a relationship between Alzheimer’s disease (AD) and dyslipidemia, although the nature of this association is not well understood.

    Authors: Rahul S Desikan, Wesley K Thompson, Dominic Holland, Christopher P Hess, James B Brewer, Henrik Zetterberg, Kaj Blennow, Ole A Andreassen, Linda K McEvoy, Bradley T Hyman and Anders M Dale

    Citation: Molecular Neurodegeneration 2013 8:39

    Content type: Research article

    Published on:

  19. Authors: Aurélien Lathuilière, Stéphanie Papin, Matthias Cacquevel, Paolo Paganetti, Andreas Muhs, Graham Knott, Bernard Schneider and Patrick Aebischer

    Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P27

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  20. Authors: Heike Hering, Danielle Graham, Solenne Ousson, Maud Neny, Audrey Gray, Brandy Giacomozzi, John Joyce, Vikram Dutt, Michael Busch, Andrew Cameron, Leslie Liu-Bujalski, Henry Yu, Hui Tian, Mark Shearman, Anna Quattropani, Bruno Permanne…

    Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O17

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  21. Authors: Virginie Buggia-Prévot, Celia G Fernandez, Sean Riordan, Kulandaivelu S Vetrivel, Vinod Udayar, Aureliane Elie, Margaret Lefkow, Jelita Roseman, Xavier Meckler, Sohinee Bhattacharyya, Manju George, Jack Waters, Vytautas P Bindokas, Angèle T Parent, Lawrence Rajendran, Hamid Band…

    Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O8

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1