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Page 15 of 20

  1. p23 belongs to the highly conserved p24 family of type I transmembrane proteins, which participate in the bidirectional protein transport between the endoplasmic reticulum and Golgi apparatus. Mammalian p23 ha...

    Authors: Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent and Gopal Thinakaran

    Citation: Molecular Neurodegeneration 2011 6:87

    Content type: Research article

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  2. Cerebral amyloid angiopathy (CAA) is characterized by deposition of fibrillar amyloid β (Aβ) within cerebral vessels. It is commonly seen in the elderly and almost universally present in patients with Alzheime...

    Authors: Byung Hee Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach and Gregory J Zipfel

    Citation: Molecular Neurodegeneration 2011 6:86

    Content type: Research article

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  3. The p38α MAPK isoform is a well-established therapeutic target in peripheral inflammatory diseases, but the importance of this kinase in pathological microglial activation and detrimental inflammation in CNS d...

    Authors: Bin Xing, Adam D Bachstetter and Linda J Van Eldik

    Citation: Molecular Neurodegeneration 2011 6:84

    Content type: Research article

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  4. Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson's disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic ...

    Authors: Yofre Cabeza-Arvelaiz, Sheila M Fleming, Franziska Richter, Eliezer Masliah, Marie-Francoise Chesselet and Robert H Schiestl

    Citation: Molecular Neurodegeneration 2011 6:83

    Content type: Research article

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  5. Detergent-insoluble protein accumulation and aggregation in the brain is one of the pathological hallmarks of neurodegenerative diseases. Here, we describe the identification of septin 11 (SEPT11), an enriched...

    Authors: Yair M Gozal, Nicholas T Seyfried, Marla Gearing, Jonathan D Glass, Craig J Heilman, Joanne Wuu, Duc M Duong, Dongmei Cheng, Qiangwei Xia, Howard D Rees, Jason J Fritz, Deborah S Cooper, Junmin Peng, Allan I Levey and James J Lah

    Citation: Molecular Neurodegeneration 2011 6:82

    Content type: Research article

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  6. Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons ...

    Authors: Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet and Ilya Bezprozvanny

    Citation: Molecular Neurodegeneration 2011 6:81

    Content type: Research article

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  7. Atypical expression of cell cycle regulatory proteins has been implicated in Alzheimer's disease (AD), but the molecular mechanisms by which they induce neurodegeneration are not well understood. We examined t...

    Authors: Monique Judge, Lisa Hornbeck, Huntington Potter and Jaya Padmanabhan

    Citation: Molecular Neurodegeneration 2011 6:80

    Content type: Research article

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  8. Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that is important in neuron-microglial communication, a co-receptor for HIV...

    Authors: Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp and Kurt F Hauser

    Citation: Molecular Neurodegeneration 2011 6:78

    Content type: Research article

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  9. Aggregatable amyloid β-peptide (Aβ) and non-aggregatable p3-Alcα are metabolic products of the γ-secretase cleavage of amyloid β-protein precursor (APP) and Alcadeinα (Alcα), respectively. Familial AD (FAD) -l...

    Authors: Tomoko Konno, Saori Hata, Yukiko Hamada, Yuko Horikoshi-Sakuraba, Tadashi Nakaya, Yuhki Saito, Tohru Yamamoto, Takayuki Yamamoto, Masahiro Maeda, Takeshi Ikeuchi, Sam Gandy, Hiroyasu Akatsu and Toshiharu Suzuki

    Citation: Molecular Neurodegeneration 2011 6:76

    Content type: Research article

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  10. Mitochondria have roles or appear to have roles in the pathogenesis of several chronic age-related and acute neurological disorders, including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis, Parkin...

    Authors: Yi Wang, Yan Pan, Ann Price and Lee J Martin

    Citation: Molecular Neurodegeneration 2011 6:75

    Content type: Research article

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  11. The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoi...

    Authors: Xavier Xifró, Marta Anglada-Huguet, Laura Rué, Ana Saavedra, Esther Pérez-Navarro and Jordi Alberch

    Citation: Molecular Neurodegeneration 2011 6:74

    Content type: Research article

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  12. Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degener...

    Authors: Ya-Fei Xu, Yong-Jie Zhang, Wen-Lang Lin, Xiangkun Cao, Caroline Stetler, Dennis W Dickson, Jada Lewis and Leonard Petrucelli

    Citation: Molecular Neurodegeneration 2011 6:73

    Content type: Research article

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  13. Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra (SN). Transforming growth factor-β1 (TGF-β1) levels increase in patients with PD, although the effects of thi...

    Authors: Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang and Amelia Sánchez-Capelo

    Citation: Molecular Neurodegeneration 2011 6:72

    Content type: Research article

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  14. Brain-Derived Neurotrophic Factor (BDNF) is the main candidate for neuroprotective therapy for Huntington's disease (HD), but its conditional administration is one of its most challenging problems.

    Authors: Albert Giralt, Olga Carretón, Cristina Lao-Peregrin, Eduardo D Martín and Jordi Alberch

    Citation: Molecular Neurodegeneration 2011 6:71

    Content type: Research article

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  15. APP expression misregulation can cause genetic Alzheimer's disease (AD). Recent evidences support the hypothesis that polymorphisms located in microRNA (miRNA) target sites could influence the risk of developi...

    Authors: Charlotte Delay, Frédéric Calon, Paul Mathews and Sébastien S Hébert

    Citation: Molecular Neurodegeneration 2011 6:70

    Content type: Short report

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  16. We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains and cerebrospinal fluid (CSF) with Alzheimer's disease (AD). Moreo...

    Authors: Hong Jiang, Harald Hampel, David Prvulovic, Anders Wallin, Kaj Blennow, Rena Li and Yong Shen

    Citation: Molecular Neurodegeneration 2011 6:69

    Content type: Research article

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  17. Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-...

    Authors: Amandine Jullienne, Axel Montagne, Cyrille Orset, Flavie Lesept, David E Jane, Daniel T Monaghan, Eric Maubert, Denis Vivien and Carine Ali

    Citation: Molecular Neurodegeneration 2011 6:68

    Content type: Research article

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  18. Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain. Abnormal activation of CDK5 is associated with neu...

    Authors: Leslie Crews, Rebecca Ruf, Christina Patrick, Wilmar Dumaop, Margarita Trejo-Morales, Cristian L Achim, Edward Rockenstein and Eliezer Masliah

    Citation: Molecular Neurodegeneration 2011 6:67

    Content type: Research article

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  19. Parkinson's disease (PD) is a complex disorder caused by genetic, environmental and age-related factors, and it is more prevalent in men. We aimed to identify differentially expressed genes in peripheral blood...

    Authors: Merav Kedmi, Anat Bar-Shira, Tanya Gurevich, Nir Giladi and Avi Orr-Urtreger

    Citation: Molecular Neurodegeneration 2011 6:66

    Content type: Research article

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  20. Memory deficits in Alzheimer's disease (AD) manifest together with the loss of synapses caused by the disruption of the postsynaptic density (PSD), a network of scaffold proteins located in dendritic spines. H...

    Authors: Andreas M Grabrucker, Michael J Schmeisser, Patrick T Udvardi, Magali Arons, Michael Schoen, Nathaniel S Woodling, Katrin I Andreasson, Patrick R Hof, Joseph D Buxbaum, Craig C Garner and Tobias M Boeckers

    Citation: Molecular Neurodegeneration 2011 6:65

    Content type: Research article

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  21. Trans-activation response element (TAR) DNA binding protein of 43kDa (TDP-43) is causally related to the neurodegenerative diseases frontotemporal dementia and amyotrophic lateral sclerosis being the hallmark ...

    Authors: Fabienne C Fiesel, Christine Schurr, Stephanie S Weber and Philipp J Kahle

    Citation: Molecular Neurodegeneration 2011 6:64

    Content type: Research article

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  22. Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by insidious cognitive decline and memory dysfunction. Synapse loss is the best pathological correlate of cognitive decline in ...

    Authors: Robert M Koffie, Bradley T Hyman and Tara L Spires-Jones

    Citation: Molecular Neurodegeneration 2011 6:63

    Content type: Review

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  23. Recent genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNP)s that are essentially unequivocally associated with peripheral cholesterol. Since the alleles of the APOE gene, ...

    Authors: Christopher R Simmons, Fanggeng Zou, Steven G Younkin and Steven Estus

    Citation: Molecular Neurodegeneration 2011 6:62

    Content type: Research article

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  24. The β-amyloid peptide (Aβ) contains a Gly-XXX-Gly-XXX-Gly motif in its C-terminal region that has been proposed to form a "glycine zipper" that drives the formation of toxic Aβ oligomers. We have tested this h...

    Authors: Virginia Fonte, Vishantie Dostal, Christine M Roberts, Patrick Gonzales, Pascale Lacor, Jordi Magrane, Natalie Dingwell, Emily Y Fan, Michael A Silverman, Gretchen H Stein and Christopher D Link

    Citation: Molecular Neurodegeneration 2011 6:61

    Content type: Research article

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    The Erratum to this article has been published in Molecular Neurodegeneration 2014 9:12

  25. Oxidative stress plays an important role in neuronal dysfunction and neuron loss in Alzheimer's brain. Previous studies have reported downregulation of CREB-mediated transcription by oxidative stress and Aβ. T...

    Authors: Subbiah Pugazhenthi, Maorong Wang, Serena Pham, Chun-I Sze and Christopher B Eckman

    Citation: Molecular Neurodegeneration 2011 6:60

    Content type: Research article

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  26. Huntington Disease (HD) is a neurodegenerative disorder in which caspase activation and cleavage of substrates, including the huntingtin protein, has been invoked as a pathological mechanism. Specific changes ...

    Authors: Jeffrey B Carroll, Amber L Southwell, Rona K Graham, Jason P Lerch, Dagmar E Ehrnhoefer, Li-Ping Cao, Wei-Ning Zhang, Yu Deng, Nagat Bissada, R Mark Henkelman and Michael R Hayden

    Citation: Molecular Neurodegeneration 2011 6:59

    Content type: Research article

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  27. There are sex differences in dopaminergic degeneration. Men are approximately two times as likely as premenopausal women of the same age to develop Parkinson's disease (PD). It has been shown that the local re...

    Authors: Ana I Rodriguez-Perez, Rita Valenzuela, Belen Joglar, Pablo Garrido-Gil, Maria J Guerra and Jose L Labandeira-Garcia

    Citation: Molecular Neurodegeneration 2011 6:58

    Content type: Research article

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  28. TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 expression and formation of C-terminal TDP-43 fragmentation and accumulation in the cytoplasm. Recent studies have shown that TDP-43 can accum...

    Authors: Jodi Meyerowitz, Sarah J Parker, Laura J Vella, Dominic CH Ng, Katherine A Price, Jeffrey R Liddell, Aphrodite Caragounis, Qiao-Xin Li, Colin L Masters, Takashi Nonaka, Masato Hasegawa, Marie A Bogoyevitch, Katja M Kanninen, Peter J Crouch and Anthony R White

    Citation: Molecular Neurodegeneration 2011 6:57

    Content type: Research article

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  29. Retinitis pigmentosa (RP) is an inherited eye disease characterized by the progressive degeneration of rod photoreceptor cells. Mutations in pre-mRNA splicing factors including PRPF31 have been identified as c...

    Authors: Jun Yin, Jan Brocher, Utz Fischer and Christoph Winkler

    Citation: Molecular Neurodegeneration 2011 6:56

    Content type: Research article

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  30. Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hi...

    Authors: Markel Olabarria, Harun N Noristani, Alexei Verkhratsky and José J Rodríguez

    Citation: Molecular Neurodegeneration 2011 6:55

    Content type: Research article

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  31. A recently published genome-wide association study (GWAS) of late-onset Alzheimer's disease (LOAD) revealed genome-wide significant association of variants in or near MS4A4A, CD2AP, EPHA1 and CD33. Meta-analyses ...

    Authors: Minerva M Carrasquillo, Olivia Belbin, Talisha A Hunter, Li Ma, Gina D Bisceglio, Fanggeng Zou, Julia E Crook, V Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Zbigniew K Wszolek, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Peter Passmore…

    Citation: Molecular Neurodegeneration 2011 6:54

    Content type: Research article

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  32. The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's disease, ...

    Authors: Seán M Kilbride, Sonia A Gluchowska, Jayne E Telford, Catherine O'Sullivan and Gavin P Davey

    Citation: Molecular Neurodegeneration 2011 6:53

    Content type: Research article

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  33. In Parkinson's disease there is progressive loss of dopamine containing neurons in the substantia nigra pars compacta. The neuronal damage is not limited to the substantia nigra but progresses to other regions...

    Authors: Sowmya V Yelamanchili, Amrita Datta Chaudhuri, Claudia T Flynn and Howard S Fox

    Citation: Molecular Neurodegeneration 2011 6:52

    Content type: Research article

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  34. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects spinal cord and cortical motor neurons. An increasing amount of evidence suggests that mitochondrial dysfunction cont...

    Authors: Wei Zhao, Merina Varghese, Shrishailam Yemul, Yong Pan, Alice Cheng, Paul Marano, Sadiq Hassan, Prashant Vempati, Fei Chen, Xianjuan Qian and Giulio M Pasinetti

    Citation: Molecular Neurodegeneration 2011 6:51

    Content type: Research article

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  35. Dopamine-synthesizing (dopaminergic, DA) neurons in the ventral midbrain (VM) constitute a pivotal neuronal population controlling motor behaviors, cognitive and affective brain functions, which generation cri...

    Authors: Francesca L'Episcopo, Maria F Serapide, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria C Morale, Stefano Pluchino and Bianca Marchetti

    Citation: Molecular Neurodegeneration 2011 6:49

    Content type: Research article

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  36. Parkinson's disease (PD) and cerebral ischemia are chronic and acute neurodegenerative diseases, respectively, and onsets of these diseases are thought to be induced at least by oxidative stress. PD is caused ...

    Authors: Yoshihisa Kitamura, Shotaro Watanabe, Masanobu Taguchi, Kentaro Takagi, Takuya Kawata, Kazuko Takahashi-Niki, Hiroyuki Yasui, Hiroshi Maita, Sanae MM Iguchi-Ariga and Hiroyoshi Ariga

    Citation: Molecular Neurodegeneration 2011 6:48

    Content type: Research article

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  37. Recently, several lines of evidence have shown the aberrant expression of cell-cycle-related proteins and tumor suppressor proteins in vulnerable neurons of the Alzheimer's disease (AD) brain and transgenic mo...

    Authors: Cha-Gyun Jung, Kyung-Ok Uhm, Yutaka Miura, Takashi Hosono, Hirofumi Horike, Kum Kum Khanna, Mi-Jeong Kim and Makoto Michikawa

    Citation: Molecular Neurodegeneration 2011 6:47

    Content type: Research article

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  38. CNS myelination disturbances commonly occur in chronic white matter lesions in neurodevelopmental and adult neurological disorders. Recent studies support that myelination failure can involve a disrupted cellu...

    Authors: Justin M Dean, Art Riddle, Jennifer Maire, Kelly D Hansen, Marnie Preston, Anthony P Barnes, Larry S Sherman and Stephen A Back

    Citation: Molecular Neurodegeneration 2011 6:46

    Content type: Research article

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  39. Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear ...

    Authors: Xiao-dong Pan, Yuan-gui Zhu, Nan Lin, Jing Zhang, Qin-yong Ye, Hua-pin Huang and Xiao-chun Chen

    Citation: Molecular Neurodegeneration 2011 6:45

    Content type: Research article

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  40. Prion diseases such as bovine spongiform encephalopathies (BSE) are transmissible neurodegenerative diseases which are presumably caused by an infectious conformational isoform of the cellular prion protein. P...

    Authors: Alex D Greenwood, Michelle Vincendeau, Ann-Christin Schmädicke, Judith Montag, Wolfgang Seifarth and Dirk Motzkus

    Citation: Molecular Neurodegeneration 2011 6:44

    Content type: Research article

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  41. Oxidative stress is a key pathophysiological mechanism contributing to degenerative processes in many neurodegenerative diseases and therefore, unraveling molecular mechanisms underlying various stages of oxid...

    Authors: Arunkumar Asaithambi, Arthi Kanthasamy, Hariharan Saminathan, Vellareddy Anantharam and Anumantha G Kanthasamy

    Citation: Molecular Neurodegeneration 2011 6:43

    Content type: Research article

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  42. Though originally discovered in the immune system as an important mediator of inflammation, NF-κB has recently been shown to play key roles in the central nervous system, such as synaptogenesis, synaptic plast...

    Authors: David J Shim, Li Yang, J Graham Reed, Jeffrey L Noebels, Paul J Chiao and Hui Zheng

    Citation: Molecular Neurodegeneration 2011 6:42

    Content type: Research article

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  43. Evidence shows that the insulin-like growth factor-1 (IGF-1) and leptin reduce β-amyloid (Aβ) production and tau phosphorylation, two major hallmarks of Alzheimer's disease (AD). IGF-1 expression involves the ...

    Authors: Gurdeep Marwarha, Jaya RP Prasanthi, Jared Schommer, Bhanu Dasari and Othman Ghribi

    Citation: Molecular Neurodegeneration 2011 6:41

    Content type: Research article

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  44. Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients. To establish whether pleiotrophin ha...

    Authors: Irene RE Taravini, Mariela Chertoff, Eduardo G Cafferata, José Courty, Mario G Murer, Fernando J Pitossi and Oscar S Gershanik

    Citation: Molecular Neurodegeneration 2011 6:40

    Content type: Research article

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  45. The correlation between neurofibrillary tangles of tau and disease progression in the brains of Alzheimer's disease (AD) patients remains an area of contention. Innovative data are emerging from biochemical, c...

    Authors: Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Audra L Clos, George R Jackson and Rakez Kayed

    Citation: Molecular Neurodegeneration 2011 6:39

    Content type: Research article

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  46. Abnormal accumulation and aggregation of microtubule associated proteins (MAPs) plays an important role in the pathogenesis of neurodegenerative diseases. Loss-of-function mutation of DJ-1/Park7 can cause earl...

    Authors: Zhiquan Wang, Yu Zhang, Shi Zhang, Qianqian Guo, Yuyan Tan, Xinyi Wang, Ran Xiong, Jianqing Ding and Shengdi Chen

    Citation: Molecular Neurodegeneration 2011 6:38

    Content type: Research article

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