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Page 18 of 20

  1. The current epidemics of type 2 diabetes mellitus (T2DM), non-alcoholic steatohepatitis (NASH), and Alzheimer's disease (AD) all represent insulin-resistance diseases. Previous studies linked insulin resistanc...

    Authors: Suzanne M de la Monte, Ming Tong, Margot Lawton and Lisa Longato

    Citation: Molecular Neurodegeneration 2009 4:54

    Content type: Research article

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  2. ZnT3 is a membrane Zn2+ transporter that is responsible for concentrating Zn2+ into neuronal presynaptic vesicles. Zn2+ homeostasis in the brain is relevant to Alzheimer's disease (AD) because Zn2+ released durin...

    Authors: Nancy Beyer, David TR Coulson, Shirley Heggarty, Rivka Ravid, G Brent Irvine, Jan Hellemans and Janet A Johnston

    Citation: Molecular Neurodegeneration 2009 4:53

    Content type: Research article

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  3. Environmental enrichment (EE) is known to enhance BDNF levels and neurogenesis in the adult hippocampus. To examine the role of BDNF in modulating EE-mediated adult hippocampal neurogenesis, we conditionally a...

    Authors: Se Hoon Choi, Yun Li, Luis F Parada and Sangram S Sisodia

    Citation: Molecular Neurodegeneration 2009 4:52

    Content type: Research article

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  4. Recent reports suggest that latrepirdine (Dimebon™, dimebolin), a retired Russian antihistamine, improves cognitive function in aged rodents and in patients with mild to moderate Alzheimer's disease (AD). Howe...

    Authors: John W Steele, Soong H Kim, John R Cirrito, Deborah K Verges, Jessica L Restivo, David Westaway, Paul Fraser, Peter St George Hyslop, Mary Sano, Ilya Bezprozvanny, Michelle E Ehrlich, David M Holtzman and Sam Gandy

    Citation: Molecular Neurodegeneration 2009 4:51

    Content type: Research article

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  5. N-acylethanolamines (NAEs) are lipids upregulated in response to cell and tissue injury and are involved in cytoprotection. Arachidonylethanolamide (AEA) is a well characterized NAE that is an endogenous ligan...

    Authors: R Scott Duncan, Kent D Chapman and Peter Koulen

    Citation: Molecular Neurodegeneration 2009 4:50

    Content type: Research article

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  6. Parkinson's disease (PD) results from the degeneration of dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine released in the striatum. Current oral dopamine replacement or surg...

    Authors: Torsten Falk, Shiling Zhang and Scott J Sherman

    Citation: Molecular Neurodegeneration 2009 4:49

    Content type: Short report

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  7. Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. Accordingly, it has been proposed t...

    Authors: Ganesh M Shankar and Dominic M Walsh

    Citation: Molecular Neurodegeneration 2009 4:48

    Content type: Review

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  8. While peripheral immune access to the central nervous system (CNS) is restricted and tightly controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety of insults. Infections, tra...

    Authors: Tamy C Frank-Cannon, Laura T Alto, Fiona E McAlpine and Malú G Tansey

    Citation: Molecular Neurodegeneration 2009 4:47

    Content type: Review

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  9. Variations in sortilin-related receptor (SORL1) expression and function have been implicated in Alzheimers Disease (AD). Here, to gain insights into SORL1, we evaluated SORL1 expression and splicing as a funct...

    Authors: Karrie E Grear, I-Fang Ling, James F Simpson, Jennifer L Furman, Christopher R Simmons, Shawn L Peterson, Frederick A Schmitt, William R Markesbery, Qiang Liu, Julia E Crook, Steven G Younkin, Guojun Bu and Steven Estus

    Citation: Molecular Neurodegeneration 2009 4:46

    Content type: Research article

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  10. Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain. Previous studies have found protective effects of various calc...

    Authors: Norelle C Wildburger, Avary Lin-Ye, Michelle A Baird, Debin Lei and Jianxin Bao

    Citation: Molecular Neurodegeneration 2009 4:44

    Content type: Research article

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  11. Hypercholesterolemia causes atherosclerosis in medium to large sized arteries. Cholesterol is less known for affecting the microvasculature and has not been previously reported to induce microvascular patholog...

    Authors: Sonia Franciosi, Miguel A Gama Sosa, Daniel F English, Elizabeth Oler, Twethida Oung, William GM Janssen, Rita De Gasperi, James Schmeidler, Dara L Dickstein, Christoph Schmitz, Sam Gandy, Patrick R Hof, Joseph D Buxbaum and Gregory A Elder

    Citation: Molecular Neurodegeneration 2009 4:42

    Content type: Research article

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  12. Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of β amyloid (Aβ) peptides. Aβ is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing b...

    Authors: Shuji Matsuda, Yukiko Matsuda and Luciano D'Adamio

    Citation: Molecular Neurodegeneration 2009 4:41

    Content type: Research article

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  13. Alzheimer's disease (AD) is a progressive neurodegenerative disease of the central nervous system (CNS). Recently, an increased interest in the role diet plays in the pathology of AD has resulted in a focus on...

    Authors: Steve Pedrini, Carlos Thomas, Hannah Brautigam, James Schmeidler, Lap Ho, Paul Fraser, David Westaway, Peter StGeorge Hyslop, Ralph N Martins, Joseph D Buxbaum, Giulio M Pasinetti, Dara L Dickstein, Patrick R Hof, Michelle E Ehrlich and Sam Gandy

    Citation: Molecular Neurodegeneration 2009 4:40

    Content type: Research article

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  14. Insulin-degrading enzyme (IDE) is a widely studied zinc-metalloprotease implicated in the pathogenesis of type 2 diabetes mellitus, Alzheimer disease (AD) and varicella zoster virus infection. Despite more tha...

    Authors: Anthony DelleDonne, Naomi Kouri, Lael Reinstatler, Tomoko Sahara, Lilin Li, Ji Zhao, Dennis W Dickson, Nilufer Ertekin-Taner and Malcolm A Leissring

    Citation: Molecular Neurodegeneration 2009 4:39

    Content type: Methodology

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  15. The nematode worm Caenorhabditis elegans has become an intensely studied model organism, and worm studies have made significant contributions to developmental biology and other fields. The experimental advantages...

    Authors: Dawn Teschendorf and Christopher D Link

    Citation: Molecular Neurodegeneration 2009 4:38

    Content type: Review

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  16. Sporadic Parkinson's disease (sPD) is a nervous system-wide disease that presents with a bradykinetic movement disorder and is frequently complicated by depression and cognitive impairment. sPD likely has mult...

    Authors: Charles R Arthur, Stephanie L Morton, Lisa D Dunham, Paula M Keeney and James P Bennett Jr

    Citation: Molecular Neurodegeneration 2009 4:37

    Content type: Research article

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  17. The aim of our study was to analyze the differential expression of miRNAs in the brains of BSE-infected cynomolgus macaques as a model for Creutzfeldt-Jakob disease (CJD). MicroRNAs (miRNAs) are small noncodin...

    Authors: Judith Montag, Reiner Hitt, Lennart Opitz, Walter J Schulz-Schaeffer, Gerhard Hunsmann and Dirk Motzkus

    Citation: Molecular Neurodegeneration 2009 4:36

    Content type: Short report

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  18. Apolipoprotein E allele ε4 (apoE4) is a strong risk factor for developing Alzheimer's disease (AD). Secreted apoE has a critical function in redistributing lipids among central nervous system cells to maintain...

    Authors: Toshiyuki Nakamura, Atsushi Watanabe, Takahiro Fujino, Takashi Hosono and Makoto Michikawa

    Citation: Molecular Neurodegeneration 2009 4:35

    Content type: Research article

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  19. Missense mutations and multiplications of the α-synuclein gene cause autosomal dominant familial Parkinson's disease (PD). α-Synuclein protein is also a major component of Lewy bodies, the hallmark pathological i...

    Authors: João Paulo L Daher, Mingyao Ying, Rebecca Banerjee, Rebecca S McDonald, Myriam Dumas Hahn, Lichuan Yang, M Flint Beal, Bobby Thomas, Valina L Dawson, Ted M Dawson and Darren J Moore

    Citation: Molecular Neurodegeneration 2009 4:34

    Content type: Research article

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  20. The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain i...

    Authors: Rina Yamin, Cheng Zhao, Peter B O'Connor, Ann C McKee and Carmela R Abraham

    Citation: Molecular Neurodegeneration 2009 4:33

    Content type: Research article

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  21. Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major component of t...

    Authors: Bo Su, Haihua Liu, Xinglong Wang, Shu G Chen, Sandra L Siedlak, Eisaku Kondo, Raymond Choi, Atsushi Takeda, Rudy J Castellani, George Perry, Mark A Smith, Xiongwei Zhu and Hyoung-gon Lee

    Citation: Molecular Neurodegeneration 2009 4:32

    Content type: Research article

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  22. Correction to Nural H, He P, Beach T, Sue L, Xia W, Shen Y. Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients Molecular Neurodegeneration 2009, 4:23.

    Authors: Zhenyu Zhong, Hikmet Nural, Ping He, Gina Civarella, Thomas Beach, Lucia Sue, Charles Adler, Holly Shill, John Caviness, Weiming Xia and Yong Shen

    Citation: Molecular Neurodegeneration 2009 4:30

    Content type: Erratum

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    The original article was published in Molecular Neurodegeneration 2009 4:23

  23. Recent studies of inherited neurodegenerative disorders have suggested a linkage between the propensity toward aggregation of mutant protein and disease onset. This is particularly apparent for polyglutamine (...

    Authors: Keizo Sugaya and Shiro Matsubara

    Citation: Molecular Neurodegeneration 2009 4:29

    Content type: Research article

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  24. Brain tissue from patients with Alzheimer's disease has shown an increase of phosphorylation of Tyr-682, located on the conserved Y682ENPTY motif, and Thr-668 residues, both in the intracellular domain (AID) o...

    Authors: Robert Tamayev, Dawang Zhou and Luciano D'Adamio

    Citation: Molecular Neurodegeneration 2009 4:28

    Content type: Research article

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  25. It has been hypothesized that reduced axonal transport contributes to the degeneration of neuronal processes in Parkinson's disease (PD). Mitochondria supply the adenosine triphosphate (ATP) needed to support ...

    Authors: Patricia A Trimmer, Kathleen M Schwartz, M Kathleen Borland, Luis De Taboada, Jackson Streeter and Uri Oron

    Citation: Molecular Neurodegeneration 2009 4:26

    Content type: Research article

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  26. Despite a comprehensive mapping of the Parkinson's disease (PD)-related mRNA and protein leucine-rich repeat kinase 2 (LRRK2) in the mammalian brain, its physiological function in healthy individuals remains e...

    Authors: Javorina Milosevic, Sigrid C Schwarz, Vera Ogunlade, Anne K Meyer, Alexander Storch and Johannes Schwarz

    Citation: Molecular Neurodegeneration 2009 4:25

    Content type: Research article

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  27. While numerous hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of neurodegenerative diseases, the theory of oxidative stress has received considerable support. Alt...

    Authors: Kristen A Malkus, Elpida Tsika and Harry Ischiropoulos

    Citation: Molecular Neurodegeneration 2009 4:24

    Content type: Review

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  28. The PARK7 gene encodes a protein, DJ-1, with several functions such as protection of cells from oxidative stress, sperm maturation and fertilization, and chaperone activity. Mutations in the PARK7 gene are ass...

    Authors: Hikmet Nural, Ping He, Thomas Beach, Lucia Sue, Weiming Xia and Yong Shen

    Citation: Molecular Neurodegeneration 2009 4:23

    Content type: Research article

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  29. The lipoprotein receptor system in the hippocampus is intimately involved in the modulation of synaptic transmission and plasticity. The association of specific apoE isoform expression with human neurodegenera...

    Authors: Kimberly M Korwek, Justin H Trotter, Mary Jo LaDu, Patrick M Sullivan and Edwin J Weeber

    Citation: Molecular Neurodegeneration 2009 4:21

    Content type: Research article

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  30. Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell communication and adhesion. The exact definition at the molecular...

    Authors: Philippe Marambaud, Ute Dreses-Werringloer and Valérie Vingtdeux

    Citation: Molecular Neurodegeneration 2009 4:20

    Content type: Review

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  31. The γ-secretase complex is a major therapeutic target for the prevention and treatment of Alzheimer's disease. Previous studies have shown that treatment of young APP mice with specific inhibitors of γ-secreta...

    Authors: Monica Garcia-Alloza, Meenakshi Subramanian, Diana Thyssen, Laura A Borrelli, Abdul Fauq, Pritam Das, Todd E Golde, Bradley T Hyman and Brian J Bacskai

    Citation: Molecular Neurodegeneration 2009 4:19

    Content type: Research article

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  32. The low-density lipoprotein receptor-related protein 1 (LRP1) plays critical roles in lipid metabolism, cell survival, and the clearance of amyloid-β (Aβ) peptide. Functional soluble LRP1 (sLRP1) has been dete...

    Authors: Qiang Liu, Juan Zhang, Hien Tran, Marcel M Verbeek, Karina Reiss, Steven Estus and Guojun Bu

    Citation: Molecular Neurodegeneration 2009 4:17

    Content type: Research article

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  33. In AtT-20 cells ACTH secretion is regulated by both Ca2+ and G proteins. We previously demonstrated that calnuc, an EF-hand Ca2+ binding protein which regulates Alzheimer's β-amyloid precursor protein (APP) bioge...

    Authors: Ping Lin, Thierry Fischer, Christine Lavoie, Haining Huang and Marilyn Gist Farquhar

    Citation: Molecular Neurodegeneration 2009 4:15

    Content type: Research article

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  34. Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease (AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently demonstrated that, in a g...

    Authors: Kiran Bhaskar, Megan Miller, Alexandra Chludzinski, Karl Herrup, Michael Zagorski and Bruce T Lamb

    Citation: Molecular Neurodegeneration 2009 4:14

    Content type: Research article

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  35. Since the identification of tau as the main component of neurofibrillary tangles in Alzheimer's disease and related tauopathies, and the discovery that mutations in the tau gene cause frontotemporal dementia, ...

    Authors: Tania F Gendron and Leonard Petrucelli

    Citation: Molecular Neurodegeneration 2009 4:13

    Content type: Review

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  36. Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human br...

    Authors: Stéphanie Baulac, Hope Lu, Jennifer Strahle, Ting Yang, Matthew S Goldberg, Jie Shen, Michael G Schlossmacher, Cynthia A Lemere, Qun Lu and Weiming Xia

    Citation: Molecular Neurodegeneration 2009 4:12

    Content type: Research article

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  37. Expansion of a polyglutamine repeat at the amino-terminus of huntingtin is the probable cause for Huntington's disease, a lethal progressive autosomal-dominant neurodegenerative disorders characterized by impa...

    Authors: Andreas Weiss, Ana Roscic and Paolo Paganetti

    Citation: Molecular Neurodegeneration 2009 4:11

    Content type: Research article

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  38. Although there is a strong correlation between CAG repeat length and age at onset (AO) of motor symptoms, individual Huntington disease (HD) patients may differ dramatically in onset age and disease manifestat...

    Authors: Elahe Taherzadeh-Fard, Carsten Saft, Jürgen Andrich, Stefan Wieczorek and Larissa Arning

    Citation: Molecular Neurodegeneration 2009 4:10

    Content type: Short report

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  39. α-Synuclein is a small protein that has special relevance for understanding Parkinson disease and related disorders. Not only is α-synuclein found in Lewy bodies characteristic of Parkinson disease, but also m...

    Authors: Mark R Cookson

    Citation: Molecular Neurodegeneration 2009 4:9

    Content type: Review

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  40. Midbrain dopaminergic neurons are involved in control of emotion, motivation and motor behavior. The loss of one of the subpopulations, substantia nigra pars compacta, is the pathological hallmark of one of th...

    Authors: Kambiz N Alavian and Horst H Simon

    Citation: Molecular Neurodegeneration 2009 4:6

    Content type: Short report

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  41. Gene microarray technology is an effective tool to investigate the simultaneous activity of multiple cellular pathways from hundreds to thousands of genes. However, because data in the colossal amounts generat...

    Authors: Wei Kong, Xiaoyang Mou, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers and Xudong Huang

    Citation: Molecular Neurodegeneration 2009 4:5

    Content type: Methodology

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