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  1. A number of studies have shown that increased APP levels, resulting from either a genomic locus duplication or alteration in APP regulatory sequences, can lead to development of early-onset dementias, including A...

    Authors: Neha Patel, David Hoang, Nathan Miller, Sara Ansaloni, Qihong Huang, Jack T Rogers, Jeremy C Lee and Aleister J Saunders

    Citation: Molecular Neurodegeneration 2008 3:10

    Content type: Short report

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  3. Abnormalities of microtubule-associated protein tau play a central role in neurofibrillary degeneration in several neurodegenerative disorders that collectively called tauopathies. Six isoforms of tau are expr...

    Authors: Fei Liu and Cheng-Xin Gong

    Citation: Molecular Neurodegeneration 2008 3:8

    Content type: Review

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  4. Experimental autoimmune encephalomyelitis (EAE) is commonly used to investigate mechanisms of autoimmune-mediated damage to oligodendrocytes, myelin, and axons in multiple sclerosis (MS). Four distinct autoimm...

    Authors: Dusanka S Skundric, Rujuan Dai, Vaagn L Zakarian and Weili Zhou

    Citation: Molecular Neurodegeneration 2008 3:7

    Content type: Research article

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  5. Presenilin (PS1 or PS2) is an essential component of the active γ-secretase complex that liberates the Aβ peptides from amyloid precursor protein (APP). PS1 is regarded as an atypical aspartyl protease harbori...

    Authors: Donald B Carter, Edwige Dunn, Adele M Pauley, Denise D McKinley, Timothy J Fleck, Brenda R Ellerbrook, Nancy C Stratman, Xiangdong Zhou, Carol S Himes, Jeffrey S Nye, Alfredo Tomasselli and Riqiang Yan

    Citation: Molecular Neurodegeneration 2008 3:6

    Content type: Research article

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  6. Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived...

    Authors: Celina V Zerbinatti, Joanna M Cordy, Ci-Di Chen, Maria Guillily, Sokreine Suon, William J Ray, Guy R Seabrook, Carmela R Abraham and Benjamin Wolozin

    Citation: Molecular Neurodegeneration 2008 3:5

    Content type: Research article

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  7. Alterations in multiple cellular pathways contribute to the development of chronic neurodegeneration such as a sporadic Alzheimer's disease (AD). These, in turn, involve changes in gene expression, amongst whi...

    Authors: Qing Yan Liu, Joy X Lei, Marianna Sikorska and Rugao Liu

    Citation: Molecular Neurodegeneration 2008 3:4

    Content type: Research article

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  8. Parkinson's disease (PD) is the most prevalent incurable neurodegenerative movement disorder. Mutations in LRRK2 are associated with both autosomal dominant familial and sporadic forms of PD. LRRK2 encodes a larg...

    Authors: Danling Wang, Beisha Tang, Guohua Zhao, Qian Pan, Kun Xia, Rolf Bodmer and Zhuohua Zhang

    Citation: Molecular Neurodegeneration 2008 3:3

    Content type: Short report

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  11. Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such ...

    Authors: Annat F Ikin, Mirsada Causevic, Steve Pedrini, Lyndsey S Benson, Joseph D Buxbaum, Toshiharu Suzuki, Simon Lovestone, Shigeki Higashiyama, Tomas Mustelin, Robert D Burgoyne and Sam Gandy

    Citation: Molecular Neurodegeneration 2007 2:23

    Content type: Research article

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  12. The pathogenesis of Alzheimer's disease is highly complex. While several pathologies characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark neuropathological lesions in Alzh...

    Authors: Sarah L Cole and Robert Vassar

    Citation: Molecular Neurodegeneration 2007 2:22

    Content type: Review

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  13. Mice carrying the spontaneous genetic mutation known as Wallerian degeneration slow (Wld s ) have a unique neuroprotective phenotype, where axonal and synaptic compartments o...

    Authors: Thomas M Wishart, Stephen HF MacDonald, Philip E Chen, Michael J Shipston, Michael P Coleman, Thomas H Gillingwater and Richard R Ribchester

    Citation: Molecular Neurodegeneration 2007 2:21

    Content type: Methodology

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  14. Recent studies demonstrate that in addition to its modulatory effect on APP processing, in vivo application of Liver X Receptor agonist T0901317 (T0) to APP transgenic and non-transgenic mice decreases the level ...

    Authors: Iliya Lefterov, Angie Bookout, Zhu Wang, Matthias Staufenbiel, David Mangelsdorf and Radosveta Koldamova

    Citation: Molecular Neurodegeneration 2007 2:20

    Content type: Research article

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  15. Genetically engineered neural stem cell (NSC) lines are promising vectors for the treatment of neurodegenerative diseases, particularly Parkinson's disease (PD). Neurturin (NTN), a member of the glial cell lin...

    Authors: Wei-Guo Liu, Xi-Jing Wang, Guo-Qiang Lu, Biao Li, Gang Wang and Sheng-Di Chen

    Citation: Molecular Neurodegeneration 2007 2:19

    Content type: Research article

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    The Retraction Note to this article has been published in Molecular Neurodegeneration 2009 4:45

  16. Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insolu...

    Authors: Rakez Kayed, Elizabeth Head, Floyd Sarsoza, Tommy Saing, Carl W Cotman, Mihaela Necula, Lawrence Margol, Jessica Wu, Leonid Breydo, Jennifer L Thompson, Suhail Rasool, Tatyana Gurlo, Peter Butler and Charles G Glabe

    Citation: Molecular Neurodegeneration 2007 2:18

    Content type: Research article

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  17. Alzheimer's disease (AD) is characterized by the presence of two histopathological hallmarks; the senile plaques, or extracellular deposits mainly composed of amyloid-β peptide (Aβ), and the neurofibrillary ta...

    Authors: Ismael Santa-Maria, Félix Hernández, Joaquín Del Rio, Francisco J Moreno and Jesús Avila

    Citation: Molecular Neurodegeneration 2007 2:17

    Content type: Research article

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  19. A central event in Alzheimer's disease (AD) is the regulated intramembraneous proteolysis of the β-amyloid precursor protein (APP), to generate the β-amyloid (Aβ) peptide and the APP intracellular domain (AICD...

    Authors: Can Zhang, Preeti J Khandelwal, Ranjita Chakraborty, Trinna L Cuellar, Srikant Sarangi, Shyam A Patel, Christopher P Cosentino, Michael O'Connor, Jeremy C Lee, Rudolph E Tanzi and Aleister J Saunders

    Citation: Molecular Neurodegeneration 2007 2:15

    Content type: Research article

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  20. The generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis of Alzheimer's disease (AD). Recent studies highlig...

    Authors: Rodrigo A Fuentealba, Maria Ines Barría, Jiyeon Lee, Judy Cam, Claudia Araya, Claudia A Escudero, Nibaldo C Inestrosa, Francisca C Bronfman, Guojun Bu and Maria-Paz Marzolo

    Citation: Molecular Neurodegeneration 2007 2:14

    Content type: Research article

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  23. Alzheimer's disease (AD) is characterized by a decline in cognitive function and accumulation of amyloid-β peptide (Aβ) in extracellular plaques. Mutations in amyloid precursor protein (APP) and presenilins al...

    Authors: Patricia A Lawlor, Ross J Bland, Pritam Das, Robert W Price, Vallie Holloway, Lisa Smithson, Bridget L Dicker, Matthew J During, Deborah Young and Todd E Golde

    Citation: Molecular Neurodegeneration 2007 2:11

    Content type: Research article

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  25. Since the majority of apolipoprotein E (apoE) existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL), one should focus on the role of the apoE-HDL complex rather than on that of ...

    Authors: Jian-Sheng Gong, Shin-ya Morita, Mariko Kobayashi, Tetsurou Handa, Shinobu C Fujita, Katsuhiko Yanagisawa and Makoto Michikawa

    Citation: Molecular Neurodegeneration 2007 2:9

    Content type: Research article

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  26. A critical issue in understanding Huntington's disease (HD) pathogenesis is how the ubiquitously expressed mutant huntingtin (mhtt) with an expanded polyglutamine repeat can cause selective toxicity of striata...

    Authors: Xiaofeng Gu, Véronique M André, Carlos Cepeda, Shi-Hua Li, Xiao-Jiang Li, Michael S Levine and X William Yang

    Citation: Molecular Neurodegeneration 2007 2:8

    Content type: Research article

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  27. Animal studies suggest that brain apolipoprotein E (apoE) levels influence amyloid-β (Aβ) deposition and thus risk for Alzheimer's disease (AD). We have previously demonstrated that deletion of the ATP-binding...

    Authors: Suzanne E Wahrle, Aarti R Shah, Anne M Fagan, Scott Smemo, John SK Kauwe, Andrew Grupe, Anthony Hinrichs, Kevin Mayo, Hong Jiang, Leon J Thal, Alison M Goate and David M Holtzman

    Citation: Molecular Neurodegeneration 2007 2:7

    Content type: Research article

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  28. α-synuclein is a small soluble, cytosolic protein which associates with vesicular membranes. It is a component of intracellular Lewy bodies present in Parkinson's disease and a subset of Alzheimer's disease (A...

    Authors: Verena Kallhoff, Erica Peethumnongsin and Hui Zheng

    Citation: Molecular Neurodegeneration 2007 2:6

    Content type: Research article

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  29. The pathological hallmarks of transmissible spongiform encephalopathy (TSE) diseases are the deposition of a misfolded form of a host-encoded protein (PrPres), marked astrocytosis, microglial activation and spong...

    Authors: Michael J Stobart, Debra Parchaliuk, Sharon LR Simon, Jillian LeMaistre, Jozef Lazar, Richard Rubenstein and J David Knox

    Citation: Molecular Neurodegeneration 2007 2:5

    Content type: Research article

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  30. Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides. Aβ is released from ectodomain cleaved amyloid precursor protein (APP) via intramembranous proteolysis by γ-secretas...

    Authors: Kulandaivelu S Vetrivel, Ping Gong, James W Bowen, Haipeng Cheng, Ying Chen, Meghan Carter, Phuong D Nguyen, Lisa Placanica, Felix T Wieland, Yue-Ming Li, Maria Z Kounnas and Gopal Thinakaran

    Citation: Molecular Neurodegeneration 2007 2:4

    Content type: Research article

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  31. The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in Al...

    Authors: Yuzhi Chen, Angela M Bodles, Donna L McPhie, Rachael L Neve, Robert E Mrak and W Sue T Griffin

    Citation: Molecular Neurodegeneration 2007 2:3

    Content type: Research article

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  32. Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been directly associated with inflam...

    Authors: Gemma Casadesus, Mark A Smith, Samar Basu, Jing Hua, Dae E Capobianco, Sandra L Siedlak, Xiongwei Zhu and George Perry

    Citation: Molecular Neurodegeneration 2007 2:2

    Content type: Research article

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  33. Recent attention has focused on understanding the role of the brain-renin-angiotensin-system (RAS) in stroke and neurodegenerative diseases. Direct evidence of a role for the brain-RAS in Parkinson's disease (...

    Authors: Tom N Grammatopoulos, Susan M Jones, Ferogh A Ahmadi, Brian R Hoover, Lawrence D Snell, Jesse Skoch, Vimal V Jhaveri, Andy M Poczobutt, James A Weyhenmeyer and W Michael Zawada

    Citation: Molecular Neurodegeneration 2007 2:1

    Content type: Research article

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  36. Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD). To examine whether LRRK2 is direct...

    Authors: Xiongwei Zhu, Asim Babar, Sandra L Siedlak, Qiwei Yang, Genta Ito, Takeshi Iwatsubo, Mark A Smith, George Perry and Shu G Chen

    Citation: Molecular Neurodegeneration 2006 1:17

    Content type: Research article

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  37. Signal peptide peptidase (SPP) is an intramembrane cleaving protease identified by its cleavage of several type II membrane signal peptides. Conservation of intramembrane active site residues demonstrates that...

    Authors: Andrew C Nyborg, Lauren Herl, Oksana Berezovska, Anne V Thomas, Thomas B Ladd, Karen Jansen, Bradley T Hyman and Todd E Golde

    Citation: Molecular Neurodegeneration 2006 1:16

    Content type: Research article

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  38. More than a decade has passed since apolipoprotein E4 (APOE-ε4) was identified as a primary risk factor for Alzheimer 's disease (AD), yet researchers are even now struggling to understand how the apolipoprotein ...

    Authors: G William Rebeck, Mary Jo LaDu, Steven Estus, Guojun Bu and Edwin J Weeber

    Citation: Molecular Neurodegeneration 2006 1:15

    Content type: Review

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  39. Alzheimer disease (AD) is clinically characterized by progressive memory loss, impairments in behavior, language and visual-spatial skills and ultimately, death. Epidemiological data reporting the predispositi...

    Authors: Kate M Webber, Douglas M Stocco, Gemma Casadesus, Richard L Bowen, Craig S Atwood, Laura A Previll, Peggy LR Harris, Xiongwei Zhu, George Perry and Mark A Smith

    Citation: Molecular Neurodegeneration 2006 1:14

    Content type: Research article

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  40. Amyloid β is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result ...

    Authors: Suzanne V Frankfort, Valerie D Doodeman, Remco Bakker, Linda R Tulner, Jos PCM van Campen, Paul HM Smits and Jos H Beijnen

    Citation: Molecular Neurodegeneration 2006 1:13

    Content type: Short report

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  41. Selenium is an essential micronutrient that function through selenoproteins. Selenium deficiency results in lower concentrations of selenium and selenoproteins. The brain maintains it's selenium better than ot...

    Authors: Melinda M Peters, Kristina E Hill, Raymond F Burk and Edwin J Weeber

    Citation: Molecular Neurodegeneration 2006 1:12

    Content type: Research article

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  42. Radon is a ubiquitous noble gas in the environment and a primary source of harmful radiation exposure for humans; it decays in a cascade of daughters (RAD) by releasing the cell damaging high energy alpha part...

    Authors: Berislav Momčilović, Glenn I Lykken and Marvin Cooley

    Citation: Molecular Neurodegeneration 2006 1:11

    Content type: Research article

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  43. Over 5,000 participants attended the 10th International Conference on Alzheimer's Disease (ICAD) and Related Disorders in Madrid, Spain from July 15–20, 2006. Highlights of the conference included reports on b...

    Authors: Suzanne Elizabeth Wahrle

    Citation: Molecular Neurodegeneration 2006 1:10

    Content type: Meeting report

    Published on:

  44. Cognitive performance declines with increasing age. Possible cellular mechanisms underlying this age-related functional decline remain incompletely understood. Early studies attributed this functional decline ...

    Authors: Mingbo Han, Frank Schottler, Debin Lei, Elizabeth Y Dong, Alexander Bryan and Jianxin Bao

    Citation: Molecular Neurodegeneration 2006 1:9

    Content type: Research article

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  46. Aberrant hyperphosphorylation of tau protein has been implicated in a variety of neurodegenerative disorders. Although a number of protein kinases have been shown to phosphorylate tau in vitro and in vivo, the mo...

    Authors: Xue Zhang, Yun-wu Zhang, Shijie Liu, Ayelen Bulloj, Gary G Tong, Zhuohua Zhang, Francesca-Fang Liao and Huaxi Xu

    Citation: Molecular Neurodegeneration 2006 1:7

    Content type: Research article

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  47. The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias. Here, we have investigated the effects of a series of commercially availa...

    Authors: Chad A Dickey, Peter Ash, Natalia Klosak, Wing C Lee, Leonard Petrucelli, Michael Hutton and Christopher B Eckman

    Citation: Molecular Neurodegeneration 2006 1:6

    Content type: Research article

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  48. The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains...

    Authors: Hui Zheng and Edward H Koo

    Citation: Molecular Neurodegeneration 2006 1:5

    Content type: Review

    Published on:

  49. The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been...

    Authors: Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah and Todd E Golde

    Citation: Molecular Neurodegeneration 2006 1:3

    Content type: Research article

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  50. Despite the existence of several scientific journals that publish research papers and reviews related to neurodegenerative diseases, a journal specifically devoted to the molecular and cellular aspects of dise...

    Authors: Guojun Bu, Huaxi Xu and Todd E Golde

    Citation: Molecular Neurodegeneration 2006 1:1

    Content type: Editorial

    Published on:

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Molecular Neurodegeneration

ISSN: 1750-1326