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  1. Research article

    Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

    Alzheimer’s disease (AD)-linked β-amyloid (Aβ) accumulates in multivesicular bodies (MVBs) with the onset of AD pathogenesis. Alterations in endosomes are among the earliest changes associated with AD but the ...

    Katarina Willén, James R. Edgar, Takafumi Hasegawa, Nobuyuki Tanaka, Clare E. Futter and Gunnar K. Gouras

    Molecular Neurodegeneration 2017 12:61

    Published on: 23 August 2017

  2. Short report

    Lysosomal processing of progranulin

    Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to th...

    Xiaolai Zhou, Daniel H. Paushter, Tuancheng Feng, Lirong Sun, Thomas Reinheckel and Fenghua Hu

    Molecular Neurodegeneration 2017 12:62

    Published on: 23 August 2017

  3. Research article

    High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

    Alzheimer’s Disease (AD), characterized by accumulation of beta-amyloid (Aβ) plaques in the brain, can be caused by age-related failures to clear Aβ from the brain through pathways that involve the cerebrovasc...

    Jérôme Robert, Emily B. Button, Sophie Stukas, Guilaine K. Boyce, Ebrima Gibbs, Catherine M. Cowan, Megan Gilmour, Wai Hang Cheng, Sonja K. Soo, Brian Yuen, Arvin Bahrabadi, Kevin Kang, Iva Kulic, Gordon Francis, Neil Cashman and Cheryl L. Wellington

    Molecular Neurodegeneration 2017 12:60

    Published on: 22 August 2017

  4. Research article

    Absence of CX3CR1 impairs the internalization of Tau by microglia

    Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism.

    Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández and Jesús Avila

    Molecular Neurodegeneration 2017 12:59

    Published on: 15 August 2017

  5. Research article

    Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

    Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer’s disease (AD), pathological tau accumulation correlates with cognit...

    Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis and Adriana Di Polo

    Molecular Neurodegeneration 2017 12:58

    Published on: 3 August 2017

  6. Review

    TREM2 in Neurodegenerative Diseases

    TREM2 variants have been identified as risk factors for Alzheimer’s disease (AD) and other neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively expressed on immune cells, identificat...

    Taylor R. Jay, Victoria E. von Saucken and Gary E. Landreth

    Molecular Neurodegeneration 2017 12:56

    Published on: 2 August 2017

  7. Research article

    Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring

    Adverse effects in diabetic mothers offspring (DMO) are a major concern of increasing incidence. Among these, chronic central complications in DMO remain poorly understood, and in extreme cases, diabetes can e...

    Juan Jose Ramos-Rodriguez, Daniel Sanchez-Sotano, Alberto Doblas-Marquez, Carmen Infante-Garcia, Simon Lubian-Lopez and Monica Garcia-Alloza

    Molecular Neurodegeneration 2017 12:57

    Published on: 2 August 2017

  8. Short report

    The lysosomal protein cathepsin L is a progranulin protease

    Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has...

    Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson and Leonard Petrucelli

    Molecular Neurodegeneration 2017 12:55

    Published on: 25 July 2017

  9. Research article

    A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

    Autosomal-dominant mutations in the Park8 gene encoding Leucine-rich repeat kinase 2 (LRRK2) have been identified to cause up to 40% of the genetic forms of Parkinson’s disease. However, the function and molecula...

    Alena Salašová, Chika Yokota, David Potěšil, Zbyněk Zdráhal, Vítězslav Bryja and Ernest Arenas

    Molecular Neurodegeneration 2017 12:54

    Published on: 11 July 2017

  10. Research article

    TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

    Excessive synaptic loss is thought to be one of the earliest events in Alzheimer’s disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunctio...

    Anthony Bosson, Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson and Mireille Albrieux

    Molecular Neurodegeneration 2017 12:53

    Published on: 6 July 2017

  11. Research article

    Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

    Alpha-synuclein (α-syn) aggregation represents the pathological hallmark of α-synucleinopathies like Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Toll-like rece...

    Serena Venezia, Violetta Refolo, Alexia Polissidis, Leonidas Stefanis, Gregor K. Wenning and Nadia Stefanova

    Molecular Neurodegeneration 2017 12:52

    Published on: 4 July 2017

  12. Research article

    Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

    Given multiple studies of brain microRNA (miRNA) in relation to Alzheimer’s disease (AD) with few consistent results and the heterogeneity of this disease, the objective of this study was to explore their mech...

    Ellis Patrick, Sathyapriya Rajagopal, Hon-Kit Andus Wong, Cristin McCabe, Jishu Xu, Anna Tang, Selina H. Imboywa, Julie A. Schneider, Nathalie Pochet, Anna M. Krichevsky, Lori B. Chibnik, David A. Bennett and Philip L. De Jager

    Molecular Neurodegeneration 2017 12:51

    Published on: 1 July 2017

  13. Review

    Glial contributions to neurodegeneration in tauopathies

    Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation of the tau protein into filamentous inclusions that can be found in neurons and glial cells. Activated microglia, astrocy...

    Cheryl E. G. Leyns and David M. Holtzman

    Molecular Neurodegeneration 2017 12:50

    Published on: 29 June 2017

  14. Review

    Targeting psychologic stress signaling pathways in Alzheimer’s disease

    Alzheimer’s Disease (AD) is the most prevalent progressive neurodegenerative disease; to date, no AD therapy has proven effective in delaying or preventing the disease course. In the search for novel therapeut...

    Hunter S. Futch, Cara L. Croft, Van Q. Truong, Eric G. Krause and Todd E. Golde

    Molecular Neurodegeneration 2017 12:49

    Published on: 21 June 2017

  15. Research article

    Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

    Presenilins play a major role in the pathogenesis of Alzheimer’s disease, in which the hippocampus is particularly vulnerable. Previous studies of Presenilin function in the synapse, however, focused exclusive...

    Sang Hun Lee, David Lutz, Mohanad Mossalam, Vadim Y. Bolshakov, Michael Frotscher and Jie Shen

    Molecular Neurodegeneration 2017 12:48

    Published on: 15 June 2017

  16. Research article

    A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

    Amyotrophic Lateral Sclerosis (ALS) is a fatal and progressive neurodegenerative disorder with identified genetic causes representing a significant minority of all cases. A GGGGCC hexanucleotide repeat expansi...

    Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller and Zane Zeier

    Molecular Neurodegeneration 2017 12:46

    Published on: 12 June 2017

  17. Research article

    Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies

    Parkinson’s’ disease (PD) and Multiple System Atrophy (MSA) are progressive brain disorders characterized by intracellular accumulations of α-synuclein and nerve cell loss in specific brain areas. This loss ca...

    Tomasz Brudek, Kristian Winge, Jonas Folke, Søren Christensen, Karina Fog, Bente Pakkenberg and Lars Østergaard Pedersen

    Molecular Neurodegeneration 2017 12:44

    Published on: 7 June 2017

  18. Review

    Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

    Parkinson’s disease is a multifactorial neurodegenerative disorder, the aetiology of which remains elusive. The primary clinical feature of progressively impaired motor control is caused by a loss of midbrain ...

    James A. Duce, Bruce X. Wong, Hannah Durham, Jean-Christophe Devedjian, David P. Smith and David Devos

    Molecular Neurodegeneration 2017 12:45

    Published on: 7 June 2017

  19. Research article

    Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

    Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whe...

    Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson III, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson and Paramita Chakrabarty

    Molecular Neurodegeneration 2017 12:40

    Published on: 29 May 2017

  20. Review

    Endoplasmic reticulum stress and inflammation in the central nervous system

    Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegene...

    Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sánchez and Gordon P. Meares

    Molecular Neurodegeneration 2017 12:42

    Published on: 25 May 2017

  21. Research article

    Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

    Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and re...

    Takashi Miyamoto, Liana Stein, Reuben Thomas, Biljana Djukic, Praveen Taneja, Joseph Knox, Keith Vossel and Lennart Mucke

    Molecular Neurodegeneration 2017 12:41

    Published on: 19 May 2017

  22. Research article

    Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

    Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post...

    Nicholas B. Hastings, Xiaohai Wang, Lixin Song, Brent D. Butts, Diane Grotz, Richard Hargreaves, J. Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X. Lu, Maureen Maguire, Veeravan Mahadomrongkul…

    Molecular Neurodegeneration 2017 12:39

    Published on: 18 May 2017

  23. Methodology

    Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129

    Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, the current H129 derived tracers...

    Wen-Bo Zeng, Hai-Fei Jiang, Ya-Dong Gang, Yi-Ge Song, Zhang-Zhou Shen, Hong Yang, Xiao Dong, Yong-Lu Tian, Rong-Jun Ni, Yaping Liu, Na Tang, Xinyan Li, Xuan Jiang, Ding Gao, Michelle Androulakis, Xiao-Bin He…

    Molecular Neurodegeneration 2017 12:38

    Published on: 12 May 2017

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