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  1. Amyloid β is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result ...

    Authors: Suzanne V Frankfort, Valerie D Doodeman, Remco Bakker, Linda R Tulner, Jos PCM van Campen, Paul HM Smits and Jos H Beijnen

    Citation: Molecular Neurodegeneration 2006 1:13

    Content type: Short report

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  2. Selenium is an essential micronutrient that function through selenoproteins. Selenium deficiency results in lower concentrations of selenium and selenoproteins. The brain maintains it's selenium better than ot...

    Authors: Melinda M Peters, Kristina E Hill, Raymond F Burk and Edwin J Weeber

    Citation: Molecular Neurodegeneration 2006 1:12

    Content type: Research article

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  3. Radon is a ubiquitous noble gas in the environment and a primary source of harmful radiation exposure for humans; it decays in a cascade of daughters (RAD) by releasing the cell damaging high energy alpha part...

    Authors: Berislav Momčilović, Glenn I Lykken and Marvin Cooley

    Citation: Molecular Neurodegeneration 2006 1:11

    Content type: Research article

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  4. Over 5,000 participants attended the 10th International Conference on Alzheimer's Disease (ICAD) and Related Disorders in Madrid, Spain from July 15–20, 2006. Highlights of the conference included reports on b...

    Authors: Suzanne Elizabeth Wahrle

    Citation: Molecular Neurodegeneration 2006 1:10

    Content type: Meeting report

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  5. Cognitive performance declines with increasing age. Possible cellular mechanisms underlying this age-related functional decline remain incompletely understood. Early studies attributed this functional decline ...

    Authors: Mingbo Han, Frank Schottler, Debin Lei, Elizabeth Y Dong, Alexander Bryan and Jianxin Bao

    Citation: Molecular Neurodegeneration 2006 1:9

    Content type: Research article

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  6. Aberrant hyperphosphorylation of tau protein has been implicated in a variety of neurodegenerative disorders. Although a number of protein kinases have been shown to phosphorylate tau in vitro and in vivo, the mo...

    Authors: Xue Zhang, Yun-wu Zhang, Shijie Liu, Ayelen Bulloj, Gary G Tong, Zhuohua Zhang, Francesca-Fang Liao and Huaxi Xu

    Citation: Molecular Neurodegeneration 2006 1:7

    Content type: Research article

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  7. The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias. Here, we have investigated the effects of a series of commercially availa...

    Authors: Chad A Dickey, Peter Ash, Natalia Klosak, Wing C Lee, Leonard Petrucelli, Michael Hutton and Christopher B Eckman

    Citation: Molecular Neurodegeneration 2006 1:6

    Content type: Research article

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  8. The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains...

    Authors: Hui Zheng and Edward H Koo

    Citation: Molecular Neurodegeneration 2006 1:5

    Content type: Review

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  9. Mutations in PSEN1 and PSEN2 genes account for the majority of cases of early-onset familial Alzheimer disease. Since the first prediction of a genetic link between PSEN1 and PSEN2 with Alzheimer's disease, many ...

    Authors: Kulandaivelu S Vetrivel, Yun-wu Zhang, Huaxi Xu and Gopal Thinakaran

    Citation: Molecular Neurodegeneration 2006 1:4

    Content type: Review

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  10. The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been...

    Authors: Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah and Todd E Golde

    Citation: Molecular Neurodegeneration 2006 1:3

    Content type: Research article

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  11. Presenilin-dependent γ-secretase cleavage of several transmembrane proteins, including amyloid-β precursor protein and Notch, mediates the intramembrane proteolysis to liberate their intracellular domains that...

    Authors: Taisuke Tomita, Sayaka Tanaka, Yuichi Morohashi and Takeshi Iwatsubo

    Citation: Molecular Neurodegeneration 2006 1:2

    Content type: Research article

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  12. Despite the existence of several scientific journals that publish research papers and reviews related to neurodegenerative diseases, a journal specifically devoted to the molecular and cellular aspects of dise...

    Authors: Guojun Bu, Huaxi Xu and Todd E Golde

    Citation: Molecular Neurodegeneration 2006 1:1

    Content type: Editorial

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