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  1. Content type: Research article

    Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS) with accumulation of misfolded SOD1 proteins as intracellular inclusions in spinal mo...

    Authors: Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa and Yoshiaki Furukawa

    Citation: Molecular Neurodegeneration 2017 12:2

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  2. Content type: Research article

    Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn ...

    Authors: Emily J. Koller, Mieu M. T. Brooks, Todd E. Golde, Benoit I. Giasson and Paramita Chakrabarty

    Citation: Molecular Neurodegeneration 2017 12:1

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  3. Content type: Review

    Alzheimer’s disease (AD) transgenic mice have been used as a standard AD model for basic mechanistic studies and drug discovery. These mouse models showed symbolic AD pathologies including β-amyloid (Aβ) plaqu...

    Authors: Se Hoon Choi, Young Hye Kim, Luisa Quinti, Rudolph E. Tanzi and Doo Yeon Kim

    Citation: Molecular Neurodegeneration 2016 11:75

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  4. Content type: Research article

    Autophagy is a bulk degradation pathway for long-lived proteins, protein aggregates, and damaged organelles. ULK1 protein kinase and Vps34 lipid kinase are two key autophagy regulators that are critical for au...

    Authors: Mitchell S. Wold, Junghyun Lim, Véronik Lachance, Zhiqiang Deng and Zhenyu Yue

    Citation: Molecular Neurodegeneration 2016 11:76

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  5. Content type: Research article

    Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it’s expressed by many cells but highly expressed by the choroid plexus and the predominant apolipopro...

    Authors: Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard and Rashid Deane

    Citation: Molecular Neurodegeneration 2016 11:74

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    The Erratum to this article has been published in Molecular Neurodegeneration 2017 12:3

  6. Content type: Research article

    Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimer’s disease (AD). Increasing evidence suggests that insulin resistance pl...

    Authors: Roy Chun-Laam Ng, On-Yin Cheng, Min Jian, Jason Shing-Cheong Kwan, Philip Wing-Lok Ho, Kenneth King-Yip Cheng, Patrick Ka Kit Yeung, Lena Lei Zhou, Ruby Lai-Chong Hoo, Sookja Kim Chung, Aimin Xu, Karen Siu-Ling. Lam and Koon Ho Chan

    Citation: Molecular Neurodegeneration 2016 11:71

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  7. Content type: Short report

    Genetic analyses showed that the triggering receptor expressed in myeloid cells 2 (TREM2) p.R47H variant increases the risk for Alzheimer’s disease (AD). The question of whether the p.R47H mutation affects exp...

    Authors: Li Ma, Mariet Allen, Nobutaka Sakae, Nilufer Ertekin-Taner, Neill R. Graff-Radford, Dennis W. Dickson, Steven G. Younkin and Daniel Sevlever

    Citation: Molecular Neurodegeneration 2016 11:72

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  8. Content type: Research article

    The pathological features of Parkinson’s disease (PD) include an abnormal accumulation of α-synuclein in the surviving dopaminergic neurons. Though PD is multifactorial, several epidemiological reports show an...

    Authors: Ashutosh Kumar, Douglas Ganini and Ronald P. Mason

    Citation: Molecular Neurodegeneration 2016 11:70

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  9. Content type: Research article

    Peripheral nerve injury is a frequent cause of lasting motor deficits and chronic pain. Although peripheral nerves are capable of regrowth they often fail to re-innervate target tissues.

    Authors: Christine Altmann, Verica Vasic, Stefanie Hardt, Juliana Heidler, Annett Häussler, Ilka Wittig, Mirko H. H. Schmidt and Irmgard Tegeder

    Citation: Molecular Neurodegeneration 2016 11:69

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  10. Content type: Research article

    Neurons have intrinsic capability to regenerate after lesion, though not spontaneously. Spinal cord injury (SCI) causes permanent neurological impairments partly due to formation of a glial scar that is compos...

    Authors: Harun Najib Noristani, Jean Charles Sabourin, Hassan Boukhaddaoui, Emilie Chan-Seng, Yannick Nicolas Gerber and Florence Evelyne Perrin

    Citation: Molecular Neurodegeneration 2016 11:68

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  11. Content type: Research article

    The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer’s disease. However, BACE1 therapeutic inhibition may cause unwanted adverse effects due to its additional functions in the...

    Authors: Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn, Kathryn M. Munro, Jenny M. Gunnersen, Hiroshi Takeshima, Regina Feederle, Iryna Voytyuk, Bart De Strooper, Mikail D. Levasseur, Brian J. Hrupka, Stephan A. Müller and Stefan F. Lichtenthaler

    Citation: Molecular Neurodegeneration 2016 11:67

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  12. Content type: Research article

    Presenilin-1 (PS1), the active component of the intramembrane γ-secretase complex, can be detected as soluble heteromeric aggregates in cerebrospinal fluid (CSF). The aim of this study was to examine the diffe...

    Authors: Aitana Sogorb-Esteve, María-Salud García-Ayllón, Juan Fortea, Raquel Sánchez-Valle, Alberto Lleó, José-Luis Molinuevo and Javier Sáez-Valero

    Citation: Molecular Neurodegeneration 2016 11:66

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  13. Content type: Research article

    Cerebrospinal fluid (CSF) biomarkers have gained increasing importance in the diagnostic work-up of Alzheimer’s disease (AD). The core CSF biomarkers related to AD pathology (Aβ42, t-tau and p-tau) are current...

    Authors: Claudia Cicognola, Davide Chiasserini, Paolo Eusebi, Ulf Andreasson, Hugo Vanderstichele, Henrik Zetterberg, Lucilla Parnetti and Kaj Blennow

    Citation: Molecular Neurodegeneration 2016 11:65

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  14. Content type: Research article

    Synthetic zinc finger (ZF) proteins can be targeted to desired DNA sequences and are useful tools for gene therapy. We recently developed a ZF transcription repressor (ZF-KOX1) able to bind to expanded DNA CAG...

    Authors: Carmen Agustín-Pavón, Michal Mielcarek, Mireia Garriga-Canut and Mark Isalan

    Citation: Molecular Neurodegeneration 2016 11:64

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  15. Content type: Research article

    Christianson Syndrome, a recently identified X-linked neurodevelopmental disorder, is caused by mutations in the human gene SLC9A6 encoding the recycling endosomal alkali cation/proton exchanger NHE6. The pati...

    Authors: Alina Ilie, Andy Y. L. Gao, Jonathan Reid, Annie Boucher, Cassandra McEwan, Hervé Barrière, Gergely L. Lukacs, R. Anne McKinney and John Orlowski

    Citation: Molecular Neurodegeneration 2016 11:63

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  16. Content type: Research article

    A few tau immunotherapies are now in clinical trials with several more likely to be initiated in the near future. A priori, it can be anticipated that an antibody which broadly recognizes various pathological ...

    Authors: Erin E. Congdon, Yan Lin, Hameetha B. Rajamohamedsait, Dov B. Shamir, Senthilkumar Krishnaswamy, Wajitha J. Rajamohamedsait, Suhail Rasool, Veronica Gonzalez, Josien Levenga, Jiaping Gu, Charles Hoeffer and Einar M. Sigurdsson

    Citation: Molecular Neurodegeneration 2016 11:62

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  17. Content type: Methodology

    Alpha-synuclein (asyn) has been shown to play an important role in the neuropathology of Parkinson’s disease (PD). In the diseased brain, classic intraneuronal inclusions called Lewy bodies contain abnormal fo...

    Authors: Natalie Landeck, Hélène Hall, Mustafa T. Ardah, Nour K. Majbour, Omar M. A. El-Agnaf, Glenda Halliday and Deniz Kirik

    Citation: Molecular Neurodegeneration 2016 11:61

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  18. Content type: Research article

    Our previous studies of Alzheimer’s disease (AD) suggested that glutamine broadly improves cellular readiness to respond to stress and acts as a neuroprotectant both in vitro and in AD mouse models. We now exp...

    Authors: Jianmin Chen, Yanping Chen, Graham Vail, Heiman Chow, Yang Zhang, Lauren Louie, Jiali Li, Ronald P. Hart, Mark R. Plummer and Karl Herrup

    Citation: Molecular Neurodegeneration 2016 11:60

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    The Erratum to this article has been published in Molecular Neurodegeneration 2017 12:4

  19. Content type: Research article

    Genome-wide association studies have identified BIN1 within the second most significant susceptibility locus in late-onset Alzheimer’s disease (AD). BIN1 undergoes complex alternative splicing to generate multipl...

    Authors: Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L. L. Clayton, Jared B. Vasquez, Carson van Sanford, Robert J. Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C. Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel…

    Citation: Molecular Neurodegeneration 2016 11:59

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  20. Content type: Research article

    We used lentiviral vectors (LVs) to generate a new SCA7 animal model overexpressing a truncated mutant ataxin-7 (MUT ATXN7) fragment in the mouse cerebellum, in order to characterize the specific neuropatholog...

    Authors: Sandro Alves, Thibaut Marais, Maria-Grazia Biferi, Denis Furling, Martina Marinello, Khalid El Hachimi, Nathalie Cartier, Merle Ruberg, Giovanni Stevanin, Alexis Brice, Martine Barkats and Annie Sittler

    Citation: Molecular Neurodegeneration 2016 11:58

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  21. Content type: Research article

    Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial serine/threonine kinase that plays a critical role in mitophagy,...

    Authors: Jaekwang Kim, Fabienne C. Fiesel, Krystal C. Belmonte, Roman Hudec, Wang-Xia Wang, Chaeyoung Kim, Peter T. Nelson, Wolfdieter Springer and Jungsu Kim

    Citation: Molecular Neurodegeneration 2016 11:55

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  22. Content type: Methodology

    Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease with death on average within 2–3 years of symptom onset. Mutations in superoxide dismutase 1 (SOD1) have been identified to cause ALS. ...

    Authors: Alexander McGown, Dame Pamela J. Shaw and Tennore Ramesh

    Citation: Molecular Neurodegeneration 2016 11:56

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  23. Content type: Research article

    The inflammatory myeloid cell activation is one of the hallmarks of experimental autoimmune encephalomyelitis (EAE), yet the in vivo role of the inflammatory myeloid cell activation in EAE has not been clearly...

    Authors: Min Jung Lee, So Jin Bing, Jonghee Choi, Minhee Jang, Gihyun Lee, Hyunkyoung Lee, Byung Soo Chang, Youngheun Jee, Sung Joong Lee and Ik-Hyun Cho

    Citation: Molecular Neurodegeneration 2016 11:54

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  24. Content type: Research article

    Disease progression in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), as one of its animal models, is characterized by demyelination and neuronal damage in white and gray matter s...

    Authors: Reiner Schneider, Barbara Koop, Friederike Schröter, Jason Cline, Jens Ingwersen, Carsten Berndt, Hans-Peter Hartung, Orhan Aktas and Tim Prozorovski

    Citation: Molecular Neurodegeneration 2016 11:53

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  25. Content type: Research article

    Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder worldwide. Clinically, AD is characterized by impairments of memory and cognitive functions. Accumulation of amyloid-β (Aβ) and neurofi...

    Authors: Ramon Velazquez, Darren M. Shaw, Antonella Caccamo and Salvatore Oddo

    Citation: Molecular Neurodegeneration 2016 11:52

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  26. Content type: Research article

    Apolipoprotein E (ApoE) is a major lipid carrier that supports lipid transport and injury repair in the brain. The APOE ε4 allele is associated with depression, mild cognitive impairment (MCI) and dementia; howev...

    Authors: Lan-yan Lin, Jing Zhang, Xiao-man Dai, Nai-an Xiao, Xi-lin Wu, Zhen Wei, Wen-ting Fang, Yuan-gui Zhu and Xiao-chun Chen

    Citation: Molecular Neurodegeneration 2016 11:51

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  27. Content type: Review

    Alzheimer’s disease (AD) is an incurable and debilitating chronic progressive neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a heterogeneous and multifactorial disorder, his...

    Authors: Syed Faraz Kazim and Khalid Iqbal

    Citation: Molecular Neurodegeneration 2016 11:50

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  28. Content type: Short report

    α-synucleinopathy emerges quite early in olfactory structures such as the olfactory bulb and anterior olfactory nucleus (OB/AON) in Parkinson's disease. This may contribute to smell impairments years before th...

    Authors: Daniel M. Mason, Negin Nouraei, Deepti B. Pant, Kristin M. Miner, Daniel F. Hutchison, Kelvin C. Luk, John F. Stolz and Rehana K. Leak

    Citation: Molecular Neurodegeneration 2016 11:49

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    The Erratum to this article has been published in Molecular Neurodegeneration 2016 11:57

  29. Content type: Review

    Immunization against amyloid-β (Aβ) peptides deposited in Alzheimer’s disease (AD) has shown considerable therapeutic effect in animal models however, the translation into human Alzheimer’s patients is challen...

    Authors: Holger Cynis, Jeffrey L. Frost, Helen Crehan and Cynthia A. Lemere

    Citation: Molecular Neurodegeneration 2016 11:48

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  30. Content type: Research article

    Neurons are highly polarized cells in which asymmetric axonal-dendritic distribution of proteins is crucial for neuronal function. Loss of polarized distribution of the axonal protein tau is an early sign of A...

    Authors: Peter Dongmin Sohn, Tara E. Tracy, Hye-In Son, Yungui Zhou, Renata E. P. Leite, Bruce L. Miller, William W. Seeley, Lea T. Grinberg and Li Gan

    Citation: Molecular Neurodegeneration 2016 11:47

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  31. Content type: Research article

    Progranulin (PGRN) is a secreted growth factor important for neuronal survival and may do so, in part, by regulating lysosome homeostasis. Mutations in the PGRN gene (GRN) are a common cause of frontotemporal lob...

    Authors: Christopher J. Holler, Georgia Taylor, Zachary T. McEachin, Qiudong Deng, William J. Watkins, Kathryn Hudson, Charles A. Easley, William T. Hu, Chadwick M. Hales, Wilfried Rossoll, Gary J. Bassell and Thomas Kukar

    Citation: Molecular Neurodegeneration 2016 11:46

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  32. Content type: Research article

    The aggregation of amyloid-β (Aβ) into insoluble plaques is a hallmark pathology of Alzheimer’s disease (AD). Previous work has shown increasing serotonin levels with selective serotonin re-uptake inhibitor (S...

    Authors: Jonathan R. Fisher, Clare E. Wallace, Danielle L. Tripoli, Yvette I. Sheline and John R. Cirrito

    Citation: Molecular Neurodegeneration 2016 11:45

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  33. Content type: Methodology

    To date, there are no effective disease-modifying treatments for Alzheimer’s disease (AD). In order to develop new therapeutics for stages where they are most likely to be effective, it is important to identif...

    Authors: Claire S. Harwell and Michael P. Coleman

    Citation: Molecular Neurodegeneration 2016 11:44

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  34. Content type: Research article

    Pathological Golgi fragmentation represents a constant pre-clinical feature of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) but its molecular mechanisms remain hitherto unclear.

    Authors: Sarah Bellouze, Gilbert Baillat, Dorothée Buttigieg, Pierre de la Grange, Catherine Rabouille and Georg Haase

    Citation: Molecular Neurodegeneration 2016 11:43

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  35. Content type: Erratum

    Authors: Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, NiCole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns…

    Citation: Molecular Neurodegeneration 2016 11:42

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    The original article was published in Molecular Neurodegeneration 2016 11:31

  36. Content type: Erratum

    Authors: Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Manel Ben Aissa, John Larson, Andrew F. Teich, Ottavio Arancio, Yohan D’Souza, Ahmed Elharram, Kevin Koster, Leon M. Tai, Mary Jo LaDu, Brian M. Bennett and Gregory R. J. Thatcher

    Citation: Molecular Neurodegeneration 2016 11:40

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    The original article was published in Molecular Neurodegeneration 2016 11:35

  37. Content type: Review

    Alzheimer's disease (AD) is the most common cause of dementia in those over the age of 65. While a numerous of disease-causing genes and risk factors have been identified, the exact etiological mechanisms of A...

    Authors: Juan Yang, Song Li, Xi-Biao He, Cheng Cheng and Weidong Le

    Citation: Molecular Neurodegeneration 2016 11:39

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  38. Content type: Research article

    Despite the clear physical association between activated astrocytes and amyloid-β (Aβ) plaques, the importance of astrocytes and their therapeutic potential in Alzheimer’s disease remain elusive. Soluble Aβ ag...

    Authors: Sofia Söllvander, Elisabeth Nikitidou, Robin Brolin, Linda Söderberg, Dag Sehlin, Lars Lannfelt and Anna Erlandsson

    Citation: Molecular Neurodegeneration 2016 11:38

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  39. Content type: Research article

    The accumulation, aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to the pathogenesis of Alzheimer’s disease (AD). Alzheimer’s disease risk increases significantly in individuals...

    Authors: Yuan Fu, Jing Zhao, Yuka Atagi, Henrietta M. Nielsen, Chia-Chen Liu, Honghua Zheng, Mitsuru Shinohara, Takahisa Kanekiyo and Guojun Bu

    Citation: Molecular Neurodegeneration 2016 11:37

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  40. Content type: Research article

    Mutations in the progranulin gene (GRN) are the most common cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology is characterized by the hyperphosphorylation of the prote...

    Authors: Carolina Alquezar, Irene G. Salado, Ana de la Encarnación, Daniel I. Pérez, Fermín Moreno, Carmen Gil, Adolfo López de Munain, Ana Martínez and Ángeles Martín-Requero

    Citation: Molecular Neurodegeneration 2016 11:36

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  41. Content type: Research article

    Clinical failures singularly targeting amyloid-β pathology indicate a critical need for alternative Alzheimer’s disease (AD) therapeutic strategies. The mixed pathology reported in a large population of AD pat...

    Authors: Jia Luo, Sue H. Lee, Lawren VandeVrede, Zhihui Qin, Manel Ben Aissa, John Larson, Andrew F. Teich, Ottavio Arancio, Yohan D’Souza, Ahmed Elharram, Kevin Koster, Leon M. Tai, Mary Jo LaDu, Brian M. Bennett and Gregory R. J. Thatcher

    Citation: Molecular Neurodegeneration 2016 11:35

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    The Erratum to this article has been published in Molecular Neurodegeneration 2016 11:40

  42. Content type: Methodology

    Apoptosis takes place in naturally occurring neuronal death, but also in aging, neurodegenerative disorders, and traumatic brain injuries. Caspase 3 (Casp3) is the most important effector protease in apoptosis...

    Authors: Laura Lossi, Carolina Cocito, Silvia Alasia and Adalberto Merighi

    Citation: Molecular Neurodegeneration 2016 11:34

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  43. Content type: Research article

    A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. The m...

    Authors: Ghulam Jeelani Pir, Bikash Choudhary, Eckhard Mandelkow and Eva-Maria Mandelkow

    Citation: Molecular Neurodegeneration 2016 11:33

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  44. Content type: Research article

    Biological pathways that significantly contribute to sporadic Alzheimer’s disease are largely unknown and cannot be observed directly. Cognitive symptoms appear only decades after the molecular disease onset, ...

    Authors: Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, NiCole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns…

    Citation: Molecular Neurodegeneration 2016 11:31

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    The Erratum to this article has been published in Molecular Neurodegeneration 2016 11:42

  45. Content type: Methodology

    Tauopathy is characterized by neurofibrillary tangles composed of insoluble hyperphosphorylated tau protein. Currently, cellular models that mimic neurofibrillary tangles in vitro are lacking. Previous studies...

    Authors: Yin Xu, Heidi Martini-Stoica and Hui Zheng

    Citation: Molecular Neurodegeneration 2016 11:32

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  46. Content type: Research article

    The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in neuronal pathophysiology. Using JNK inhibitors, we examined involvement of the JNK pathway in cultured rat retinal ganglion cell (...

    Authors: Byung-Jin Kim, Sean M. Silverman, Yang Liu, Robert J. Wordinger, Iok-Hou Pang and Abbot F. Clark

    Citation: Molecular Neurodegeneration 2016 11:30

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