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  1. Content type: Research article

    Previous studies regarding the lipid-cognition relation in older adults are limited and have generated mixed results. We thus examined whether higher blood cholesterol concentrations were associated with faste...

    Authors: Chaoran Ma, Zhaoxue Yin, Pengfei Zhu, Jiesi Luo, Xiaoming Shi and Xiang Gao

    Citation: Molecular Neurodegeneration 2017 12:24

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  2. Content type: Research article

    Reduction or inhibition of histone deacetylase 6 (HDAC6) has been shown to rescue memory in mouse models of Alzheimer’s disease (AD) and is recently being considered a possible therapeutic strategy. However, t...

    Authors: Heesun Choi, Haeng Jun Kim, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Seung Jae Hyeon, Dong-Sup Lee, Hoon Ryu, Junho Chung and Inhee Mook-Jung

    Citation: Molecular Neurodegeneration 2017 12:23

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  3. Content type: Research article

    The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against...

    Authors: Prateep Pakavathkumar, Anastasia Noël, Clotilde Lecrux, Agne Tubeleviciute-Aydin, Edith Hamel, Jan-Eric Ahlfors and Andrea C. LeBlanc

    Citation: Molecular Neurodegeneration 2017 12:22

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  4. Content type: Research article

    The ubiquitin-proteasome-system (UPS) is the major intracellular pathway leading to the degradation of unwanted and/or misfolded soluble proteins. This includes proteins regulating cellular survival, synaptic ...

    Authors: Tobias Engel, Jaime Martinez-Villarreal, Christine Henke, Eva M. Jimenez-Mateos, Amaya Sanz-Rodriguez, Mariana Alves, Yasmina Hernandez-Santana, Gary P. Brennan, Aidan Kenny, Aoife Campbell, Jose J. Lucas and David C. Henshall

    Citation: Molecular Neurodegeneration 2017 12:21

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  5. Content type: Research article

    The ability of oligodendrocyte progenitor cells (OPCs) to give raise to myelin forming cells during developmental myelination, normal adult physiology and post-lesion remyelination in white matter depends on f...

    Authors: Camille Leonetti, Richard Macrez, Mathilde Pruvost, Yannick Hommet, Jérémie Bronsard, Antoine Fournier, Maxime Perrigault, Isabel Machin, Denis Vivien, Diego Clemente, Fernando De Castro, Eric Maubert and Fabian Docagne

    Citation: Molecular Neurodegeneration 2017 12:20

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  6. Content type: Review

    Abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of tauopathies remains unclear. Consequentl...

    Authors: Laure Saint-Aubert, Laetitia Lemoine, Konstantinos Chiotis, Antoine Leuzy, Elena Rodriguez-Vieitez and Agneta Nordberg

    Citation: Molecular Neurodegeneration 2017 12:19

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  7. Content type: Research article

    Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptide...

    Authors: Erik Portelius, Niklas Mattsson, Josef Pannee, Henrik Zetterberg, Magnus Gisslén, Hugo Vanderstichele, Eleni Gkanatsiou, Gabriela A. N. Crespi, Michael W. Parker, Luke A. Miles, Johan Gobom and Kaj Blennow

    Citation: Molecular Neurodegeneration 2017 12:18

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  8. Content type: Research article

    Reactive microglia have been associated with the histological changes that occur in Parkinson’s disease brains and mouse models of the disease. Multiple studies from autopsy brains have verified the presence o...

    Authors: Gunjan Dhawan Manocha, Angela Marie Floden, Kendra Lynn Puig, Kumi Nagamoto-Combs, Clemens R. Scherzer and Colin Kelly Combs

    Citation: Molecular Neurodegeneration 2017 12:17

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  9. Content type: Research article

    Neuroinflammation is associated with a wide range of neurodegenerative disorders, however the specific contribution to individual disease pathogenesis and selective neuronal cell death is not well understood. ...

    Authors: Michael Lattke, Stephanie N. Reichel, Alexander Magnutzki, Alireza Abaei, Volker Rasche, Paul Walther, Dinis P. Calado, Boris Ferger, Thomas Wirth and Bernd Baumann

    Citation: Molecular Neurodegeneration 2017 12:16

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  10. Content type: Research article

    Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to ...

    Authors: Katarzyna Marta Zoltowska, Masato Maesako, Iryna Lushnikova, Shuko Takeda, Laura J. Keller, Galina Skibo, Bradley T. Hyman and Oksana Berezovska

    Citation: Molecular Neurodegeneration 2017 12:15

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  11. Content type: Research article

    Alzheimer’s disease (AD) is characterized by progressive cognitive decline and memory loss. Environmental factors and gene-environment interactions (GXE) may increase AD risk, accelerate cognitive decline, and...

    Authors: Anna K. Engstrom, Jessica M. Snyder, Nobuyo Maeda and Zhengui Xia

    Citation: Molecular Neurodegeneration 2017 12:14

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    The Correction to this article has been published in Molecular Neurodegeneration 2017 12:81

  12. Content type: Research article

    TDP-43 proteinopathy is a prominent pathological feature that occurs in a number of human diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and inclusion body myositis (IBM...

    Authors: Yun Ha Jeong, Jonathan P. Ling, Sophie Z. Lin, Aneesh N. Donde, Kerstin E. Braunstein, Elisa Majounie, Bryan J. Traynor, Katherine D. LaClair, Thomas E. Lloyd and Philip C. Wong

    Citation: Molecular Neurodegeneration 2017 12:13

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  13. Content type: Research article

    APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer’s disease (AD). Here we investigated how APOE genotype influences respo...

    Authors: Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M. Sullivan, David M. Holtzman and Martin J. Sadowski

    Citation: Molecular Neurodegeneration 2017 12:12

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  14. Content type: Review

    Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson’s Disease (PD). Genetic studies have identified mutat...

    Authors: Tim E. Moors, Jeroen J. M. Hoozemans, Angela Ingrassia, Tommaso Beccari, Lucilla Parnetti, Marie-Christine Chartier-Harlin and Wilma D. J. van de Berg

    Citation: Molecular Neurodegeneration 2017 12:11

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  15. Content type: Research article

    LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and...

    Authors: Daniel C. Berwick, Behzad Javaheri, Andrea Wetzel, Mark Hopkinson, Jonathon Nixon-Abell, Simone Grannò, Andrew A. Pitsillides and Kirsten Harvey

    Citation: Molecular Neurodegeneration 2017 12:9

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  16. Content type: Research article

    Glycerophosphodiester phosphodiesterase 2 (GDE2) is a six-transmembrane protein that cleaves glycosylphosphatidylinositol (GPI) anchors to regulate GPI-anchored protein activity at the cell surface. In the dev...

    Authors: Clinton Cave, Sungjin Park, Marianeli Rodriguez, Mai Nakamura, Ahmet Hoke, Mikhail Pletnikov and Shanthini Sockanathan

    Citation: Molecular Neurodegeneration 2017 12:8

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  17. Content type: Review

    Oxidative stress is a common denominator in the pathology of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple scle...

    Authors: Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M. Dhandapani, Ratna K. Vadlamudi and Darrell W. Brann

    Citation: Molecular Neurodegeneration 2017 12:7

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  18. Content type: Research article

    The most frequent genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the expansion of a GGGGCC hexanucleotide repeat in a non-coding region of the chromosome 9...

    Authors: Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer and Bettina Schmid

    Citation: Molecular Neurodegeneration 2017 12:6

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  19. Content type: Research article

    Tau pathology in AD spreads in a hierarchical pattern, whereby it first appears in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas. Based on this sequential appearance...

    Authors: Yipeng Wang, Varun Balaji, Senthilvelrajan Kaniyappan, Lars Krüger, Stephan Irsen, Katharina Tepper, RamReddy Chandupatla, Walter Maetzler, Anja Schneider, Eckhard Mandelkow and Eva-Maria Mandelkow

    Citation: Molecular Neurodegeneration 2017 12:5

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  20. Content type: Erratum

    Authors: Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard and Rashid Deane

    Citation: Molecular Neurodegeneration 2017 12:3

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    The original article was published in Molecular Neurodegeneration 2016 11:74

  21. Content type: Research article

    Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS) with accumulation of misfolded SOD1 proteins as intracellular inclusions in spinal mo...

    Authors: Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa and Yoshiaki Furukawa

    Citation: Molecular Neurodegeneration 2017 12:2

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  22. Content type: Research article

    Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn ...

    Authors: Emily J. Koller, Mieu M. T. Brooks, Todd E. Golde, Benoit I. Giasson and Paramita Chakrabarty

    Citation: Molecular Neurodegeneration 2017 12:1

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  23. Content type: Research article

    Autophagy is a bulk degradation pathway for long-lived proteins, protein aggregates, and damaged organelles. ULK1 protein kinase and Vps34 lipid kinase are two key autophagy regulators that are critical for au...

    Authors: Mitchell S. Wold, Junghyun Lim, Véronik Lachance, Zhiqiang Deng and Zhenyu Yue

    Citation: Molecular Neurodegeneration 2016 11:76

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  24. Content type: Review

    Alzheimer’s disease (AD) transgenic mice have been used as a standard AD model for basic mechanistic studies and drug discovery. These mouse models showed symbolic AD pathologies including β-amyloid (Aβ) plaqu...

    Authors: Se Hoon Choi, Young Hye Kim, Luisa Quinti, Rudolph E. Tanzi and Doo Yeon Kim

    Citation: Molecular Neurodegeneration 2016 11:75

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  25. Content type: Research article

    Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it’s expressed by many cells but highly expressed by the choroid plexus and the predominant apolipopro...

    Authors: Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard and Rashid Deane

    Citation: Molecular Neurodegeneration 2016 11:74

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    The Erratum to this article has been published in Molecular Neurodegeneration 2017 12:3

  26. Content type: Short report

    Genetic analyses showed that the triggering receptor expressed in myeloid cells 2 (TREM2) p.R47H variant increases the risk for Alzheimer’s disease (AD). The question of whether the p.R47H mutation affects exp...

    Authors: Li Ma, Mariet Allen, Nobutaka Sakae, Nilufer Ertekin-Taner, Neill R. Graff-Radford, Dennis W. Dickson, Steven G. Younkin and Daniel Sevlever

    Citation: Molecular Neurodegeneration 2016 11:72

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  27. Content type: Research article

    Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimer’s disease (AD). Increasing evidence suggests that insulin resistance pl...

    Authors: Roy Chun-Laam Ng, On-Yin Cheng, Min Jian, Jason Shing-Cheong Kwan, Philip Wing-Lok Ho, Kenneth King-Yip Cheng, Patrick Ka Kit Yeung, Lena Lei Zhou, Ruby Lai-Chong Hoo, Sookja Kim Chung, Aimin Xu, Karen Siu-Ling. Lam and Koon Ho Chan

    Citation: Molecular Neurodegeneration 2016 11:71

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  28. Content type: Research article

    The pathological features of Parkinson’s disease (PD) include an abnormal accumulation of α-synuclein in the surviving dopaminergic neurons. Though PD is multifactorial, several epidemiological reports show an...

    Authors: Ashutosh Kumar, Douglas Ganini and Ronald P. Mason

    Citation: Molecular Neurodegeneration 2016 11:70

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  29. Content type: Research article

    Peripheral nerve injury is a frequent cause of lasting motor deficits and chronic pain. Although peripheral nerves are capable of regrowth they often fail to re-innervate target tissues.

    Authors: Christine Altmann, Verica Vasic, Stefanie Hardt, Juliana Heidler, Annett Häussler, Ilka Wittig, Mirko H. H. Schmidt and Irmgard Tegeder

    Citation: Molecular Neurodegeneration 2016 11:69

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  30. Content type: Research article

    Neurons have intrinsic capability to regenerate after lesion, though not spontaneously. Spinal cord injury (SCI) causes permanent neurological impairments partly due to formation of a glial scar that is compos...

    Authors: Harun Najib Noristani, Jean Charles Sabourin, Hassan Boukhaddaoui, Emilie Chan-Seng, Yannick Nicolas Gerber and Florence Evelyne Perrin

    Citation: Molecular Neurodegeneration 2016 11:68

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  31. Content type: Research article

    The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer’s disease. However, BACE1 therapeutic inhibition may cause unwanted adverse effects due to its additional functions in the...

    Authors: Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn, Kathryn M. Munro, Jenny M. Gunnersen, Hiroshi Takeshima, Regina Feederle, Iryna Voytyuk, Bart De Strooper, Mikail D. Levasseur, Brian J. Hrupka, Stephan A. Müller and Stefan F. Lichtenthaler

    Citation: Molecular Neurodegeneration 2016 11:67

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  32. Content type: Research article

    Presenilin-1 (PS1), the active component of the intramembrane γ-secretase complex, can be detected as soluble heteromeric aggregates in cerebrospinal fluid (CSF). The aim of this study was to examine the diffe...

    Authors: Aitana Sogorb-Esteve, María-Salud García-Ayllón, Juan Fortea, Raquel Sánchez-Valle, Alberto Lleó, José-Luis Molinuevo and Javier Sáez-Valero

    Citation: Molecular Neurodegeneration 2016 11:66

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  33. Content type: Research article

    Cerebrospinal fluid (CSF) biomarkers have gained increasing importance in the diagnostic work-up of Alzheimer’s disease (AD). The core CSF biomarkers related to AD pathology (Aβ42, t-tau and p-tau) are current...

    Authors: Claudia Cicognola, Davide Chiasserini, Paolo Eusebi, Ulf Andreasson, Hugo Vanderstichele, Henrik Zetterberg, Lucilla Parnetti and Kaj Blennow

    Citation: Molecular Neurodegeneration 2016 11:65

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  34. Content type: Research article

    Synthetic zinc finger (ZF) proteins can be targeted to desired DNA sequences and are useful tools for gene therapy. We recently developed a ZF transcription repressor (ZF-KOX1) able to bind to expanded DNA CAG...

    Authors: Carmen Agustín-Pavón, Michal Mielcarek, Mireia Garriga-Canut and Mark Isalan

    Citation: Molecular Neurodegeneration 2016 11:64

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  35. Content type: Research article

    Christianson Syndrome, a recently identified X-linked neurodevelopmental disorder, is caused by mutations in the human gene SLC9A6 encoding the recycling endosomal alkali cation/proton exchanger NHE6. The pati...

    Authors: Alina Ilie, Andy Y. L. Gao, Jonathan Reid, Annie Boucher, Cassandra McEwan, Hervé Barrière, Gergely L. Lukacs, R. Anne McKinney and John Orlowski

    Citation: Molecular Neurodegeneration 2016 11:63

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  36. Content type: Research article

    A few tau immunotherapies are now in clinical trials with several more likely to be initiated in the near future. A priori, it can be anticipated that an antibody which broadly recognizes various pathological ...

    Authors: Erin E. Congdon, Yan Lin, Hameetha B. Rajamohamedsait, Dov B. Shamir, Senthilkumar Krishnaswamy, Wajitha J. Rajamohamedsait, Suhail Rasool, Veronica Gonzalez, Josien Levenga, Jiaping Gu, Charles Hoeffer and Einar M. Sigurdsson

    Citation: Molecular Neurodegeneration 2016 11:62

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  37. Content type: Methodology

    Alpha-synuclein (asyn) has been shown to play an important role in the neuropathology of Parkinson’s disease (PD). In the diseased brain, classic intraneuronal inclusions called Lewy bodies contain abnormal fo...

    Authors: Natalie Landeck, Hélène Hall, Mustafa T. Ardah, Nour K. Majbour, Omar M. A. El-Agnaf, Glenda Halliday and Deniz Kirik

    Citation: Molecular Neurodegeneration 2016 11:61

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  38. Content type: Research article

    Our previous studies of Alzheimer’s disease (AD) suggested that glutamine broadly improves cellular readiness to respond to stress and acts as a neuroprotectant both in vitro and in AD mouse models. We now exp...

    Authors: Jianmin Chen, Yanping Chen, Graham Vail, Heiman Chow, Yang Zhang, Lauren Louie, Jiali Li, Ronald P. Hart, Mark R. Plummer and Karl Herrup

    Citation: Molecular Neurodegeneration 2016 11:60

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    The Erratum to this article has been published in Molecular Neurodegeneration 2017 12:4

  39. Content type: Research article

    Genome-wide association studies have identified BIN1 within the second most significant susceptibility locus in late-onset Alzheimer’s disease (AD). BIN1 undergoes complex alternative splicing to generate multipl...

    Authors: Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L. L. Clayton, Jared B. Vasquez, Carson van Sanford, Robert J. Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C. Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel…

    Citation: Molecular Neurodegeneration 2016 11:59

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  40. Content type: Research article

    We used lentiviral vectors (LVs) to generate a new SCA7 animal model overexpressing a truncated mutant ataxin-7 (MUT ATXN7) fragment in the mouse cerebellum, in order to characterize the specific neuropatholog...

    Authors: Sandro Alves, Thibaut Marais, Maria-Grazia Biferi, Denis Furling, Martina Marinello, Khalid El Hachimi, Nathalie Cartier, Merle Ruberg, Giovanni Stevanin, Alexis Brice, Martine Barkats and Annie Sittler

    Citation: Molecular Neurodegeneration 2016 11:58

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  41. Content type: Methodology

    Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease with death on average within 2–3 years of symptom onset. Mutations in superoxide dismutase 1 (SOD1) have been identified to cause ALS. ...

    Authors: Alexander McGown, Dame Pamela J. Shaw and Tennore Ramesh

    Citation: Molecular Neurodegeneration 2016 11:56

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  42. Content type: Research article

    Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial serine/threonine kinase that plays a critical role in mitophagy,...

    Authors: Jaekwang Kim, Fabienne C. Fiesel, Krystal C. Belmonte, Roman Hudec, Wang-Xia Wang, Chaeyoung Kim, Peter T. Nelson, Wolfdieter Springer and Jungsu Kim

    Citation: Molecular Neurodegeneration 2016 11:55

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  43. Content type: Research article

    The inflammatory myeloid cell activation is one of the hallmarks of experimental autoimmune encephalomyelitis (EAE), yet the in vivo role of the inflammatory myeloid cell activation in EAE has not been clearly...

    Authors: Min Jung Lee, So Jin Bing, Jonghee Choi, Minhee Jang, Gihyun Lee, Hyunkyoung Lee, Byung Soo Chang, Youngheun Jee, Sung Joong Lee and Ik-Hyun Cho

    Citation: Molecular Neurodegeneration 2016 11:54

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  44. Content type: Research article

    Disease progression in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), as one of its animal models, is characterized by demyelination and neuronal damage in white and gray matter s...

    Authors: Reiner Schneider, Barbara Koop, Friederike Schröter, Jason Cline, Jens Ingwersen, Carsten Berndt, Hans-Peter Hartung, Orhan Aktas and Tim Prozorovski

    Citation: Molecular Neurodegeneration 2016 11:53

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  45. Content type: Research article

    Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder worldwide. Clinically, AD is characterized by impairments of memory and cognitive functions. Accumulation of amyloid-β (Aβ) and neurofi...

    Authors: Ramon Velazquez, Darren M. Shaw, Antonella Caccamo and Salvatore Oddo

    Citation: Molecular Neurodegeneration 2016 11:52

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  46. Content type: Research article

    Apolipoprotein E (ApoE) is a major lipid carrier that supports lipid transport and injury repair in the brain. The APOE ε4 allele is associated with depression, mild cognitive impairment (MCI) and dementia; howev...

    Authors: Lan-yan Lin, Jing Zhang, Xiao-man Dai, Nai-an Xiao, Xi-lin Wu, Zhen Wei, Wen-ting Fang, Yuan-gui Zhu and Xiao-chun Chen

    Citation: Molecular Neurodegeneration 2016 11:51

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