Articles

Pioglitazone ameliorates the phenotype of a novel Parkinson’s disease mouse model by reducing neuroinflammation

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. The cause of the motor symptoms is the loss of dopaminergic neurons in the substantia nigra with...

Authors: Milena Pinto, Nadee Nissanka, Susana Peralta, Roberta Brambilla, Francisca Diaz and Carlos T. Moraes

C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

C1q represents the initiating protein of the classical complement cascade, however recent findings indicate pathway independent roles such as developmental pruning of retinal ganglion cell (RGC) axons. Further...

Authors: Sean M. Silverman, Byung-Jin Kim, Garreth R. Howell, Joselyn Miller, Simon W. M. John, Robert J. Wordinger and Abbot F. Clark

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

Interleukin-1 beta (IL-1β) and its key regulator, the inflammasome, are suspected to play a role in the neuroinflammation observed in Alzheimer’s disease (AD); no conclusive data are nevertheless available in ...

Authors: Marina Saresella, Francesca La Rosa, Federica Piancone, Martina Zoppis, Ivana Marventano, Elena Calabrese, Veronica Rainone, Raffaello Nemni, Roberta Mancuso and Mario Clerici

Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease

Increasing evidence suggests a potential therapeutic benefit of vitamin D supplementation against Alzheimer’s disease (AD). Although studies have shown improvements in cognitive performance and decreases in ma...

Authors: Véréna Landel, Pascal Millet, Kévin Baranger, Béatrice Loriod and François Féron

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis

In frontotemporal dementia (FTD) there is a critical lack in the understanding of biological and molecular mechanisms involved in disease pathogenesis. The heterogeneous genetic features associated with FTD su...

Authors: Raffaele Ferrari, Paola Forabosco, Jana Vandrovcova, Juan A. Botía, Sebastian Guelfi, Jason D. Warren, Parastoo Momeni, Michael E. Weale, Mina Ryten and John Hardy

Erratum to: Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

Authors: Wendy E. Heywood, Daniela Galimberti, Emily Bliss, Ernestas Sirka, Ross W. Paterson, Nadia K. Magdalinou, Miryam Carecchio, Emma Reid, Amanda Heslegrave, Chiara Fenoglio, Elio Scarpini, Jonathan M. Schott, Nick C. Fox, John Hardy, Kailash P. Bhatia, Simon Heales…

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

The metalloprotease meprin β cleaves the Alzheimer’s Disease (AD) relevant amyloid precursor protein (APP) as a β-secretase reminiscent of BACE-1, however, predominantly generating N-terminally truncated Aβ2-x...

Authors: Caroline Schönherr, Jessica Bien, Simone Isbert, Rielana Wichert, Johannes Prox, Hermann Altmeppen, Sathish Kumar, Jochen Walter, Stefan F. Lichtenthaler, Sascha Weggen, Markus Glatzel, Christoph Becker-Pauly and Claus U. Pietrzik

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo

Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-depe...

Authors: Emily Sempou, Emiliano Biasini, Alejandro Pinzón-Olejua, David A. Harris and Edward Málaga-Trillo

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions – e.g. neurodegenerative diseases – often requires long-term ...

Authors: Matteo Cornaglia, Gopalan Krishnamani, Laurent Mouchiroud, Vincenzo Sorrentino, Thomas Lehnert, Johan Auwerx and Martin A. M. Gijs

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

Alzheimer disease (AD) and other tauopathies develop cerebral intracellular inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence suggests a clear link between type 2 diabetes mellit...

Authors: Erica Barini, Odetta Antico, Yingjun Zhao, Francesco Asta, Valter Tucci, Tiziano Catelani, Roberto Marotta, Huaxi Xu and Laura Gasparini

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Authors: Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin, Virve Kärkkäinen, Piia Valonen, Sarka Lehtonen, Gundars Goldsteins, Tarja Malm, Katja Kanninen and Jari Koistinaho

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

A unique feature of the pathological change after spinal cord injury (SCI) is the progressive enlargement of lesion area, which usually results in cavity formation and is accompanied by reactive astrogliosis a...

Authors: Hong Fan, Kun Zhang, Lequn Shan, Fang Kuang, Kun Chen, Keqing Zhu, Heng Ma, Gong Ju and Ya-Zhou Wang

Direct α-synuclein promoter transactivation by the tumor suppressor p53

Parkinson’s disease (PD) is a motor disease associated with the degeneration of dopaminergic neurons of the substantia nigra pars compacta. p53 is a major neuronal pro-apoptotic factor that is at the center of gr...

Authors: Eric Duplan, Cécile Giordano, Frédéric Checler and Cristine Alves da Costa

Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson’s disease

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has been established as a highly effective symptomatic therapy for Parkinson’s disease (PD). A...

Authors: Affif Zaccaria, Ali Bouamrani, Stephan Chabardès, Michèle El Atifi, Eric Seigneuret, Johannes A. Lobrinus, Michel Dubois-Dauphin, François Berger and Pierre R. Burkhard

A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases

Prion diseases are characterized by the accumulation in the central nervous system of an abnormally folded isoform of the prion protein, named PrP^Sc. Aggregation of PrP^Sc into oligomers and fibrils is critically ...

Authors: Thibaut Imberdis, Adeline Ayrolles-Torro, Alysson Duarte Rodrigues, Joan Torrent, Maria Teresa Alvarez-Martinez, Gabor G. Kovacs, Jean-Michel Verdier, Mike Robitzer and Véronique Perrier

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuropla...

Authors: Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin, Virve Kärkkäinen, Piia Valonen, Sarka Lehtonen, Gundars Goldsteins, Tarja Malm, Katja Kanninen and Jari Koistinaho

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Substantial evidence suggests that amyloid-β (Aβ) species induce oxidative stress and cerebrovascular (CV) dysfunction in Alzheimer’s disease (AD), potentially contributing to the progressive dementia of this ...

Authors: Matthew R. Reynolds, Itender Singh, Tej D. Azad, Brandon B. Holmes, Phillip B. Verghese, Hans H. Dietrich, Marc Diamond, Guojun Bu, Byung Hee Han and Gregory J. Zipfel

Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein. ALS pa...

Authors: Su Min Lim, Won Jun Choi, Ki-Wook Oh, Yuanchao Xue, Ji Young Choi, Sung Hoon Kim, Minyeop Nahm, Young-Eun Kim, Jinhyuk Lee, Min-Young Noh, Seungbok Lee, Sejin Hwang, Chang-Seok Ki, Xiang-Dong Fu and Seung Hyun Kim

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patient...

Authors: Nour K. Majbour, Nishant N. Vaikath, Karin D. van Dijk, Mustafa T. Ardah, Shiji Varghese, Louise B. Vesterager, Liliana P. Montezinho, Stephen Poole, Bared Safieh-Garabedian, Takahiko Tokuda, Charlotte E. Teunissen, Henk W. Berendse, Wilma D. J. van de Berg and Omar M. A. El-Agnaf

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s disease

Mitochondrial dysfunction, oxidative stress and their interplay are core pathological features of Parkinson’s disease. In dopaminergic neurons, monoamines and their metabolites provide an additional source of ...

Authors: Mária Baranyi, Pier Francesca Porceddu, Flóra Gölöncsér, Szabina Kulcsár, Lilla Otrokocsi, Ágnes Kittel, Annalisa Pinna, Lucia Frau, Paul B. Huleatt, Mui-Ling Khoo, Christina L. L. Chai, Petra Dunkel, Peter Mátyus, Micaela Morelli and Beáta Sperlágh

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

Lrrk2, a gene linked to Parkinson’s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the pres...

Authors: Elisa Belluzzi, Adriano Gonnelli, Maria-Daniela Cirnaru, Antonella Marte, Nicoletta Plotegher, Isabella Russo, Laura Civiero, Susanna Cogo, Maria Perèz Carrion, Cinzia Franchin, Giorgio Arrigoni, Mariano Beltramini, Luigi Bubacco, Franco Onofri, Giovanni Piccoli and Elisa Greggio

Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Alzheimer’s disease (AD) is the most frequent form of dementia in the elderly and no effective treatment is currently available. The mechanisms triggering AD onset and progression are still imperfectly dissect...

Authors: Mickael Audrain, Romain Fol, Patrick Dutar, Brigitte Potier, Jean-Marie Billard, Julien Flament, Sandro Alves, Marie-Anne Burlot, Gaelle Dufayet-Chaffaud, Alexis-Pierre Bemelmans, Julien Valette, Philippe Hantraye, Nicole Déglon, Nathalie Cartier and Jérome Braudeau

The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis

The receptor for advanced glycation end products (RAGE) has been found to interact with amyloid β (Aβ). Although RAGE does not have any kinase motifs in its cytosolic domain, the interaction between RAGE and A...

Authors: Yoonhee Kim, Chaeyoung Kim, Sung Min Son, Hyundong Song, Hyun Seok Hong, Sun-ho Han and Inhee Mook-Jung

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for Alzheimer’s disease (AD), with only the apolipoprotein E (A...

Authors: Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott, Kevin Mills and Henrik Zetterberg

A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism

Apolipoprotein E (ApoE) is a major cholesterol carrier and plays an important role in maintaining lipid homeostasis both in the periphery and brain. Human APOE gene is polymorphic at two single nucleotides (rs429...

Authors: Li Zhong, Yong-Zhuang Xie, Tian-Tian Cao, Zongqi Wang, Tingting Wang, Xinxiu Li, Rui-Chi Shen, Huaxi Xu, Guojun Bu and Xiao-Fen Chen

Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5

Beclin 1 is a key regulator of multiple trafficking pathways, including autophagy and receptor recycling in yeast and microglia. Decreased beclin 1 levels in the CNS result in neurodegeneration, an effect attr...

Authors: Caitlin E. O’Brien, Liana Bonanno, Hui Zhang and Tony Wyss-Coray

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

In Alzheimer Disease (AD), the mechanistic connection of the two major pathological hallmarks, namely deposition of Amyloid-beta (Aβ) in the form of extracellular plaques, and the pathological changes of the i...

Authors: Hans Zempel and Eva-Maria Mandelkow

The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model

Although the genetic cause for Huntington’s disease (HD) has been known for over 20 years, the mechanisms that cause the neurotoxicity and behavioral symptoms of this disease are not well understood. One hypot...

Authors: Matthew B. Veldman, Yesenia Rios-Galdamez, Xiao-Hong Lu, Xiaofeng Gu, Wei Qin, Song Li, X. William Yang and Shuo Lin

α-synuclein interacts with SOD1 and promotes its oligomerization

Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are both neurodegenerative diseases leading to impaired execution of movement. α-Synuclein plays a central role in the pathogenesis of PD wherea...

Authors: Anika M. Helferich, Wolfgang P. Ruf, Veselin Grozdanov, Axel Freischmidt, Marisa S. Feiler, Lisa Zondler, Albert C. Ludolph, Pamela J. McLean, Jochen H. Weishaupt and Karin M. Danzer

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

Presynaptic terminals contribute to cognitive reserve, balancing the effects of age-related pathologies on cognitive function in the elderly. The presynaptic protein Munc18-1, alternatively spliced into long (...

Authors: Alfredo Ramos-Miguel, Christa Hercher, Clare L. Beasley, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett and William G. Honer

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

Currently there are no effective treatments for many neurodegenerative diseases. Reliable biomarkers for identifying and stratifying these diseases will be important in the development of future novel therapie...

Authors: Wendy E. Heywood, Daniela Galimberti, Emily Bliss, Ernestas Sirka, Ross W. Paterson, Nadia K. Magdalinou, Miryam Carecchio, Emma Reid, Amanda Heslegrave, Chiara Fenoglio, Elio Scarpini, Jonathan M. Schott, Nick C. Fox, John Hardy, Kailash Bahtia, Simon Heales…

Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease

Parkinson’s disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor dysfunctions. While most PD is sporadic in nature, a significant subset can be linked to eithe...

Authors: Seon-Heui Cha, Yu Ree Choi, Cheol-Ho Heo, Seo-Jun Kang, Eun-Hye Joe, Ilo Jou, Hwan-Myung Kim and Sang Myun Park

Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

L-methionine, the principal sulfur-containing amino acid in proteins, plays critical roles in cell physiology as an antioxidant and in the breakdown of fats and heavy metals. Previous studies suggesting the us...

Authors: Cheril Tapia-Rojas, Carolina B. Lindsay, Carla Montecinos-Oliva, Macarena S. Arrazola, Rocio M. Retamales, Daniel Bunout, Sandra Hirsch and Nibaldo C. Inestrosa

Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity

HIV-1-infected and/or immune-activated microglia and macrophages are pivotal in the pathogenesis of HIV-1-associated neurocognitive disorders (HAND). Glutaminase, a metabolic enzyme that facilitates glutamate ...

Authors: Beiqing Wu, Yunlong Huang, Alexander L. Braun, Zenghan Tong, Runze Zhao, Yuju Li, Fang Liu and Jialin C. Zheng

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

Dendritic simplification, a key feature of the neurodegenerative triad of Alzheimer’s disease (AD) in addition to spine changes and neuron loss, occurs in a region-specific manner. However, it is unknown how c...

Authors: Nataliya Golovyashkina, Lorène Penazzi, Carlo Ballatore, Amos B. Smith III, Lidia Bakota and Roland Brandt

Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid

Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson’s disease ...

Authors: Marco Barbariga, Flavio Curnis, Annapaola Andolfo, Alan Zanardi, Massimo Lazzaro, Antonio Conti, Giuseppe Magnani, Maria Antonietta Volontè, Laura Ferrari, Giancarlo Comi, Angelo Corti and Massimo Alessio

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates so...

Authors: Zhiqiang Xu, Na Xiao, Yali Chen, Huang Huang, Charles Marshall, Junying Gao, Zhiyou Cai, Ting Wu, Gang Hu and Ming Xiao

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

Amyotrophic Lateral Sclerosis is characterized by a focal onset of symptoms followed by a progressive spread of pathology that has been likened to transmission of infectious prions. Cell-to-cell transmission o...

Authors: Rafaa Zeineddine, Jay F. Pundavela, Lisa Corcoran, Elise M. Stewart, Dzung Do-Ha, Monique Bax, Gilles Guillemin, Kara L. Vine, Danny M. Hatters, Heath Ecroyd, Christopher M. Dobson, Bradley J. Turner, Lezanne Ooi, Mark R. Wilson, Neil R. Cashman and Justin J. Yerbury

Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway

Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer’s disease (AD) pathogenesis. Previous studies suggested that statins promote IDE secretio...

Authors: Sung Min Son, Seokjo Kang, Heesun Choi and Inhee Mook-Jung

Analysis of in vivo turnover of tau in a mouse model of tauopathy

Intracellular accumulation of tau as neurofibrillary tangles (NFTs) is the hallmark of Alzheimer’s disease (AD) as well as in other tauopathies. Tau is present not only in the cytoplasm but also in the extrace...

Authors: Kaoru Yamada, Tirth K. Patel, Katja Hochgräfe, Thomas E. Mahan, Hong Jiang, Floy R. Stewart, Eva-Maria Mandelkow and David M. Holtzman

Erratum to: Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression

Authors: Xi Chen, Hannah V. McCue, Shi Quan Wong, Sudhanva S. Kashyap, Brian C. Kraemer, Jeff W. Barclay, Robert D. Burgoyne and Alan Morgan

Depletion of highly abundant proteins from human cerebrospinal fluid: a cautionary note

Affinity-based techniques, both for enrichment or depletion of proteins of interest, suffer from unwanted interactions between the bait or matrix material and molecules different from the original target. This...

Authors: Ramona Günther, Eberhard Krause, Michael Schümann, Ingolf E. Blasig and Reiner F. Haseloff

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune proc...

Authors: Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo LaDu, David W. Fardo, G. William Rebeck and Steven Estus

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression

Many neurodegenerative diseases are associated with protein misfolding/aggregation. Treatments mitigating the effects of such common pathological processes, rather than disease-specific symptoms, therefore hav...

Authors: Xi Chen, Hannah V. McCue, Shi Quan Wong, Sudhanva S. Kashyap, Brian C. Kraemer, Jeff W. Barclay, Robert D. Burgoyne and Alan Morgan

The RAB39B p.G192R mutation causes X-linked dominant Parkinson’s disease

To identify the causal gene in a multi-incident U.S. kindred with Parkinson’s disease (PD).

Authors: Ignacio F. Mata, Yongwoo Jang, Chun-Hyung Kim, David S. Hanna, Michael O. Dorschner, Ali Samii, Pinky Agarwal, John W. Roberts, Olga Klepitskaya, David R. Shprecher, Kathryn A. Chung, Stewart A. Factor, Alberto J. Espay, Fredy J. Revilla, Donald S. Higgins, Irene Litvan…

Erratum to: Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility

Authors: Daniel Sevlever, Fanggeng Zou, Li Ma, Sebastian Carrasquillo, Michael G. Crump, Oliver J. Culley, Talisha A. Hunter, Gina D. Bisceglio, Linda Younkin, Mariet Allen, Minerva M. Carrasquillo, Sigrid B. Sando, Jan O. Aasly, Dennis W. Dickson, Neill R. Graff-Radford, Ronald C. Petersen…

A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy

Multiple system atrophy (MSA) is a progressive, neurodegenerative disease characterized by parkinsonism, resistance to dopamine therapy, ataxia, autonomic dysfunction, and pathological accumulation of α-synucl...

Authors: Brian Spencer, Elvira Valera, Edward Rockenstein, Margarita Trejo-Morales, Anthony Adame and Eliezer Masliah

Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease

Patients with advanced Parkinson's disease (PD) often present with axial symptoms, including postural- and gait difficulties that respond poorly to dopaminergic agents. Although deep brain stimulation (DBS) of...

Authors: Ilse S. Pienaar, Sarah E. Gartside, Puneet Sharma, Vincenzo De Paola, Sabine Gretenkord, Dominic Withers, Joanna L. Elson and David T. Dexter

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Pallido-ponto-nigral degeneration (PPND), a major subtype of frontotemporal dementia with parkinsonism related to chromosome 17 (FTDP-17), is a progressive and terminal neurodegenerative disease caused by c.83...

Authors: Melissa C. Wren, Jing Zhao, Chia-Chen Liu, Melissa E. Murray, Yuka Atagi, Mary D. Davis, Yuan Fu, Hirotaka J. Okano, Kotaro Ogaki, Audrey J. Strongosky, Pawel Tacik, Rosa Rademakers, Owen A. Ross, Dennis W. Dickson, Zbigniew K. Wszolek, Takahisa Kanekiyo…

TREM2 in CNS homeostasis and neurodegenerative disease

Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and regeneration. The innate immune ...

Authors: Meghan M. Painter, Yuka Atagi, Chia-Chen Liu, Rosa Rademakers, Huaxi Xu, John D. Fryer and Guojun Bu