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  1. The presenilin genes were first identified as the site of missense mutations causing early onset autosomal dominant familial Alzheimer's disease. Subsequent work has shown that the presenilin proteins are the ...

    Authors: Yi Li, Christopher Bohm, Roger Dodd, Fusheng Chen, Seema Qamar, Gerold Schmitt-Ulms, Paul E Fraser and Peter H St George-Hyslop

    Citation: Molecular Neurodegeneration 2014 9:59

    Content type: Review

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  2. Epidemiological evidence suggests that low doses of ionising radiation (≤1.0 Gy) produce persistent alterations in cognition if the exposure occurs at a young age. The mechanisms underlying such alterations ar...

    Authors: Stefan J Kempf, Arianna Casciati, Sonja Buratovic, Dirk Janik, Christine von Toerne, Marius Ueffing, Frauke Neff, Simone Moertl, Bo Stenerlöw, Anna Saran, Michael J Atkinson, Per Eriksson, Simonetta Pazzaglia and Soile Tapio

    Citation: Molecular Neurodegeneration 2014 9:57

    Content type: Research article

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  3. Understanding how inflammation causes neuronal damage is of paramount importance in multiple sclerosis (MS) and in other neurodegenerative diseases. Here we addressed the role of the apoptotic cascade in the s...

    Authors: Silvia Rossi, Caterina Motta, Valeria Studer, Giulia Macchiarulo, Elisabetta Volpe, Francesca Barbieri, Gabriella Ruocco, Fabio Buttari, Annamaria Finardi, Raffaele Mancino, Sagit Weiss, Luca Battistini, Gianvito Martino, Roberto Furlan, Jelena Drulovic and Diego Centonze

    Citation: Molecular Neurodegeneration 2014 9:56

    Content type: Research article

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  4. Traumatic brain injury (TBI) is a major health care concern that currently lacks any effective treatment. Despite promising outcomes from many preclinical studies, clinical evaluations have failed to identify ...

    Authors: Dhananjay R Namjoshi, Wai Hang Cheng, Kurt A McInnes, Kris M Martens, Michael Carr, Anna Wilkinson, Jianjia Fan, Jerome Robert, Arooj Hayat, Peter A Cripton and Cheryl L Wellington

    Citation: Molecular Neurodegeneration 2014 9:55

    Content type: Research article

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  5. Recent epidemiological evidence suggests that modifying lifestyle by increasing physical activity could be a non-pharmacological approach to improving symptoms and slowing disease progression in Alzheimer’s di...

    Authors: Odochi Ohia-Nwoko, Saghi Montazari, Yuen-Sum Lau and Jason L Eriksen

    Citation: Molecular Neurodegeneration 2014 9:54

    Content type: Research article

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  6. Synaptic degeneration is an early pathogenic event in Alzheimer’s disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be hi...

    Authors: Ann Brinkmalm, Gunnar Brinkmalm, William G Honer, Lutz Frölich, Lucrezia Hausner, Lennart Minthon, Oskar Hansson, Anders Wallin, Henrik Zetterberg, Kaj Blennow and Annika Öhrfelt

    Citation: Molecular Neurodegeneration 2014 9:53

    Content type: Research article

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  7. The relationship between the pathogenic amyloid β-peptide species Aβ1–42 and tau pathology has been well studied and suggests that Aβ1–42 can accelerate tau pathology in vitro and in vivo. The manners if any i...

    Authors: Xiaoyan Hu, Xiaoling Li, Mingrui Zhao, Andrew Gottesdiener, Wenjie Luo and Steven Paul

    Citation: Molecular Neurodegeneration 2014 9:52

    Content type: Research article

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  8. The amyloid cascade hypothesis has been the prevailing hypothesis in Alzheimer’s Disease research, although the final and most wanted proof i.e. fully successful anti-amyloid clinical trials in patients, is st...

    Authors: Ilie-Cosmin Stancu, Bruno Vasconcelos, Dick Terwel and Ilse Dewachter

    Citation: Molecular Neurodegeneration 2014 9:51

    Content type: Review

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  9. Mouse models are used in the study of human disease. Despite well-known homologies, the difference in immune response between mice and humans impacts the application of data derived from mice to human disease ...

    Authors: Michael D Hoos, Michael P Vitek, Lisa A Ridnour, Joan Wilson, Marilyn Jansen, Angela Everhart, David A Wink and Carol A Colton

    Citation: Molecular Neurodegeneration 2014 9:50

    Content type: Research article

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  10. In the recent years, a role of the immune system in Huntington’s disease (HD) is increasingly recognized. Here we investigate the presence of T cell activating auto-antibodies against angiotensin II type 1 rec...

    Authors: De-Hyung Lee, Harald Heidecke, Alexandra Schröder, Friedemann Paul, Rolf Wachter, Rainer Hoffmann, Gisa Ellrichmann, Duska Dragun, Anne Waschbisch, Johannes Stegbauer, Peter Klotz, Ralf Gold, Ralf Dechend, Dominik N Müller, Carsten Saft and Ralf A Linker

    Citation: Molecular Neurodegeneration 2014 9:49

    Content type: Research article

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  11. Alzheimer’s disease (AD) is a devastating disease characterized by synaptic and neuronal loss in the elderly. Compelling evidence suggests that soluble amyloid-β peptide (Aβ) oligomers induce synaptic loss in ...

    Authors: Shichun Tu, Shu-ichi Okamoto, Stuart A Lipton and Huaxi Xu

    Citation: Molecular Neurodegeneration 2014 9:48

    Content type: Review

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  12. Parkinson’s disease (PD), like many common age-related conditions, has been recognized to have a substantial genetic component. Multiple lines of evidence suggest that Leucine-rich repeat kinase 2 (LRRK2) is a...

    Authors: Jie-Qiong Li, Lan Tan and Jin-Tai Yu

    Citation: Molecular Neurodegeneration 2014 9:47

    Content type: Review

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  13. Tau is an axonal protein that binds to and regulates microtubule function. Hyper-phosphorylation of Tau reduces its binding to microtubules and it is associated with β-amyloid deposition in Alzheimer’s disease...

    Authors: Irina Lonskaya, Michaeline Hebron, Wenqiang Chen, Joel Schachter and Charbel Moussa

    Citation: Molecular Neurodegeneration 2014 9:46

    Content type: Research article

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  14. Loss of function COQ2 mutations results in primary CoQ10 deficiency. Recently, recessive mutations of the COQ2 gene have been identified in two unrelated Japanese families with multiple system atrophy (MSA). It h...

    Authors: Kotaro Ogaki, Shinsuke Fujioka, Michael G Heckman, Sruti Rayaprolu, Alexandra I Soto-Ortolaza, Catherine Labbé, Ronald L Walton, Oswaldo Lorenzo-Betancor, Xue Wang, Yan Asmann, Rosa Rademakers, Neill Graff-Radford, Ryan Uitti, William P Cheshire, Zbigniew K Wszolek, Dennis W Dickson…

    Citation: Molecular Neurodegeneration 2014 9:44

    Content type: Research article

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  15. The accumulation of α-synuclein aggregates is the hallmark of Parkinson’s disease, and more generally of synucleinopathies. The accumulation of tau aggregates however is classically found in the brains of pati...

    Authors: Simon Moussaud, Daryl R Jones, Elisabeth L Moussaud-Lamodière, Marion Delenclos, Owen A Ross and Pamela J McLean

    Citation: Molecular Neurodegeneration 2014 9:43

    Content type: Review

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  16. Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmarks of Alzheimer’s disease (AD). Increasing the quantity of the O-linked N-acetylglucosamine (O-GlcNAc) post-translational mo...

    Authors: Scott A Yuzwa, Xiaoyang Shan, Bryan A Jones, Gang Zhao, Melissa L Woodward, Xiaojing Li, Yanping Zhu, Ernest J McEachern, Michael A Silverman, Neil V Watson, Cheng-Xin Gong and David J Vocadlo

    Citation: Molecular Neurodegeneration 2014 9:42

    Content type: Research article

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  17. Mounting evidence suggests that soluble oligomers of amyloid-β (oAβ) represent the pertinent synaptotoxic form of Aβ in sporadic Alzheimer’s disease (AD); however, the mechanistic links between oAβ and synapti...

    Authors: Katherine A Price, Merina Varghese, Allison Sowa, Frank Yuk, Hannah Brautigam, Michelle E Ehrlich and Dara L Dickstein

    Citation: Molecular Neurodegeneration 2014 9:41

    Content type: Research article

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  18. Given the increased life expectancy of human immunodeficiency virus (HIV) infected individuals treated with combination antiretroviral therapy (cART) and the ongoing inflammation observed in the brains of thes...

    Authors: Lecia AM Brown, James Scarola, Adam J Smith, Paul R Sanberg, Jun Tan and Brian Giunta

    Citation: Molecular Neurodegeneration 2014 9:40

    Content type: Review

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  19. Optic nerve damage initiates a series of early atrophic events in retinal ganglion cells (RGCs) that precede the BAX-dependent committed step of the intrinsic apoptotic program. Nuclear atrophy, including glob...

    Authors: Heather M Schmitt, Heather R Pelzel, Cassandra L Schlamp and Robert W Nickells

    Citation: Molecular Neurodegeneration 2014 9:39

    Content type: Research article

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  20. Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9ORF72) are causative for frontotemporal dementia (FTD) and motor neuron disease (MND). Substantial phenotypic heterogeneity has been descr...

    Authors: Marka van Blitterswijk, Bianca Mullen, Aleksandra Wojtas, Michael G Heckman, Nancy N Diehl, Matthew C Baker, Mariely DeJesus-Hernandez, Patricia H Brown, Melissa E Murray, Ging-Yuek R Hsiung, Heather Stewart, Anna M Karydas, Elizabeth Finger, Andrew Kertesz, Eileen H Bigio, Sandra Weintraub…

    Citation: Molecular Neurodegeneration 2014 9:38

    Content type: Research article

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  21. Chronic traumatic encephalopathy (CTE) is a recently revived term used to describe a neurodegenerative process that occurs as a long term complication of repetitive mild traumatic brain injury (TBI). Corsellis...

    Authors: Sam Gandy, Milos D Ikonomovic, Effie Mitsis, Gregory Elder, Stephen T Ahlers, Jeffrey Barth, James R Stone and Steven T DeKosky

    Citation: Molecular Neurodegeneration 2014 9:37

    Content type: Review

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  22. The ingestion of a high-fat diet (HFD) and the resulting obese state can exert a multitude of stressors on the individual including anxiety and cognitive dysfunction. Though many studies have shown that exerci...

    Authors: Silvia S Kang, Patricio R Jeraldo, Aishe Kurti, Margret E Berg Miller, Marc D Cook, Keith Whitlock, Nigel Goldenfeld, Jeffrey A Woods, Bryan A White, Nicholas Chia and John D Fryer

    Citation: Molecular Neurodegeneration 2014 9:36

    Content type: Research article

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  23. The 5XFAD early onset mouse model of Alzheimer’s disease (AD) is gaining momentum. Behavioral, electrophysiological and anatomical studies have identified age-dependent alterations that can be reminiscent of h...

    Authors: Véréna Landel, Kévin Baranger, Isabelle Virard, Béatrice Loriod, Michel Khrestchatisky, Santiago Rivera, Philippe Benech and François Féron

    Citation: Molecular Neurodegeneration 2014 9:33

    Content type: Research article

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  24. Although genome wide studies have associated single nucleotide polymorphisms (SNP)s near PICALM with Alzheimer’s disease (AD), the mechanism underlying this association is unclear. PICALM is involved in clathrin-...

    Authors: Ishita Parikh, Christopher Medway, Steven Younkin, David W Fardo and Steven Estus

    Citation: Molecular Neurodegeneration 2014 9:32

    Content type: Research article

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  25. Intracellular protein trafficking plays an important role in neuronal function and survival. Protein misfolding is a common theme found in many neurodegenerative diseases, and intracellular trafficking machine...

    Authors: Xin Wang, Timothy Huang, Guojun Bu and Huaxi Xu

    Citation: Molecular Neurodegeneration 2014 9:31

    Content type: Review

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  26. We recently found that brain tissue from patients with type-2 diabetes (T2D) and cognitive impairment contains deposits of amylin, an amyloidogenic hormone synthesized and co-secreted with insulin by pancreati...

    Authors: Sarah Srodulski, Savita Sharma, Adam B Bachstetter, Jennifer M Brelsfoard, Conrado Pascual, Xinmin Simon Xie, Kathryn E Saatman, Linda J Van Eldik and Florin Despa

    Citation: Molecular Neurodegeneration 2014 9:30

    Content type: Research article

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  27. We recently reported that Parkinsonian and dementia phenotypes emerge between 7-12 months of age in tau-/- mice on a Bl6/129sv mixed background. These observations were partially replicated by another group using...

    Authors: Peng Lei, Scott Ayton, Steve Moon, Qihao Zhang, Irene Volitakis, David I Finkelstein and Ashley I Bush

    Citation: Molecular Neurodegeneration 2014 9:29

    Content type: Research article

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  28. Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central event in the pathogenesis of Alzheimer’s disease (AD). Besides the parenchymal pathology, Aβ is known to undergo active transpor...

    Authors: Hongmei Li, Qinxi Guo, Taeko Inoue, Vinicia A Polito, Katsuhiko Tabuchi, Robert E Hammer, Robia G Pautler, George E Taffet and Hui Zheng

    Citation: Molecular Neurodegeneration 2014 9:28

    Content type: Research article

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  29. The substantia nigra (SN) midbrain nucleus is constitutively iron rich. Iron levels elevate further with age, and pathologically in Parkinson’s disease (PD). Iron accumulation in PD SN involves dysfunction of ...

    Authors: Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush and David I Finkelstein

    Citation: Molecular Neurodegeneration 2014 9:27

    Content type: Short report

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  30. A thorough investigation of the neurobiology of HIV-induced neuronal dysfunction and its evolving phenotype in the setting of viral suppression has been limited by the lack of validated small animal models to ...

    Authors: Vez Repunte-Canonigo, Celine Lefebvre, Olivier George, Tomoya Kawamura, Marisela Morales, George F Koob, Andrea Califano, Eliezer Masliah and Pietro Paolo Sanna

    Citation: Molecular Neurodegeneration 2014 9:26

    Content type: Research article

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  31. Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mec...

    Authors: Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry WM Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman…

    Citation: Molecular Neurodegeneration 2014 9:25

    Content type: Review

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  32. Intraneuronal inclusions of TAR DNA-binding protein 43 (TDP-43) have been found in the majority of Amyotrophic Lateral Sclerosis (ALS) patients. Mutations in the gene encoding TDP-43 cause familial ALS. Transg...

    Authors: Sarah Herdewyn, Carla Cirillo, Ludo Van Den Bosch, Wim Robberecht, Pieter Vanden Berghe and Philip Van Damme

    Citation: Molecular Neurodegeneration 2014 9:24

    Content type: Research article

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  33. Parkinson’s disease (PD) is the most common movement neurodegenerative movement disorder. An incomplete understanding of the molecular pathways involved in its pathogenesis impedes the development of effective...

    Authors: Radek Linhart, Sarah Anne Wong, Jieyun Cao, Melody Tran, Anne Huynh, Casey Ardrey, Jong Min Park, Christine Hsu, Saher Taha, Rentia Peterson, Shannon Shea, Jason Kurian and Katerina Venderova

    Citation: Molecular Neurodegeneration 2014 9:23

    Content type: Research article

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  34. Alzheimer’s disease (AD) is the leading cause of dementia affecting greater than 26 million people worldwide. Although cerebrospinal fluid (CSF) levels of Aβ42, tau, and p-tau181 are well established as diagnosti...

    Authors: Kristin R Wildsmith, Stephen P Schauer, Ashley M Smith, David Arnott, Yuda Zhu, Joshua Haznedar, Surinder Kaur, W Rodney Mathews and Lee A Honigberg

    Citation: Molecular Neurodegeneration 2014 9:22

    Content type: Methodology

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  35. Recent genome-wide association studies linked variants in TREM2 to a strong increase in the odds of developing Alzheimer’s disease. The mechanism by which TREM2 influences the susceptibility to Alzheimer’s diseas...

    Authors: Jason D Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E Mahan, Hong Jiang, Floy R Stewart, Laura Piccio, Marco Colonna and David M Holtzman

    Citation: Molecular Neurodegeneration 2014 9:20

    Content type: Research article

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  36. Imaging methods are used widely to understand structure of brain and other biological objects. However, sample penetration by light microscopy is limited due to light scattering by the tissue. A number of meth...

    Authors: Ekaterina Poguzhelskaya, Dmitry Artamonov, Anastasia Bolshakova, Olga Vlasova and Ilya Bezprozvanny

    Citation: Molecular Neurodegeneration 2014 9:19

    Content type: Methodology

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  37. In dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum. However, fac...

    Authors: Cassia R Overk, Anna Cartier, Gideon Shaked, Edward Rockenstein, Kiren Ubhi, Brian Spencer, Diana L Price, Christina Patrick, Paula Desplats and Eliezer Masliah

    Citation: Molecular Neurodegeneration 2014 9:18

    Content type: Research article

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  38. 6-hydroxydopamine (6-OHDA) is one of the most commonly used toxins for modeling degeneration of dopaminergic (DA) neurons in Parkinson's disease. 6-OHDA also causes axonal degeneration, a process that appears ...

    Authors: Xi Lu, Jeong Sook Kim-Han, Steve Harmon, Shelly E Sakiyama-Elbert and Karen L O'Malley

    Citation: Molecular Neurodegeneration 2014 9:17

    Content type: Research article

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  39. The role of mitochondrial dysfunction has long been implicated in age-related brain pathology, including Alzheimer’s disease (AD). However, the mechanism by which mitochondrial dysfunction may cause neurodegen...

    Authors: Lokesh Kukreja, Gregory C Kujoth, Tomas A Prolla, Fred Van Leuven and Robert Vassar

    Citation: Molecular Neurodegeneration 2014 9:16

    Content type: Research article

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  40. We recently identified U1 small nuclear ribonucleoprotein (snRNP) tangle-like aggregates and RNA splicing abnormalities in sporadic Alzheimer’s disease (AD). However little is known about snRNP biology in earl...

    Authors: Chadwick M Hales, Nicholas T Seyfried, Eric B Dammer, Duc Duong, Hong Yi, Marla Gearing, Juan C Troncoso, Elliott J Mufson, Madhav Thambisetty, Allan I Levey and James J Lah

    Citation: Molecular Neurodegeneration 2014 9:15

    Content type: Short report

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  41. Central nervous system (CNS) trauma and neurodegenerative disorders trigger a cascade of cellular and molecular events resulting in neuronal apoptosis and regenerative failure. The pathogenic mechanisms and ge...

    Authors: Tasneem P Sharma, Colleen M McDowell, Yang Liu, Alex H Wagner, David Thole, Benjamin P Faga, Robert J Wordinger, Terry A Braun and Abbot F Clark

    Citation: Molecular Neurodegeneration 2014 9:14

    Content type: Research article

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  42. According to the modified amyloid hypothesis the main event in the pathogenesis of Alzheimer’s disease (AD) is the deposition of neurotoxic amyloid β-peptide (Aβ) within neurons. Additionally to full-length pe...

    Authors: Erika Avendaño Guzmán, Yvonne Bouter, Bernhard C Richard, Lars Lannfelt, Martin Ingelsson, Anders Paetau, Auli Verkkoniemi-Ahola, Oliver Wirths and Thomas A Bayer

    Citation: Molecular Neurodegeneration 2014 9:13

    Content type: Research article

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  43. Authors: Virginia Fonte, Vishantie Dostal, Christine M Roberts, Patrick Gonzales, Pascale N Lacor, Pauline T Velasco, Jordi Magrane, Natalie Dingwell, Emily Y Fan, Michael A Silverman, Gretchen H Stein and Christopher D Link

    Citation: Molecular Neurodegeneration 2014 9:12

    Content type: Erratum

    Published on:

    The original article was published in Molecular Neurodegeneration 2011 6:61

  44. The editors of Molecular Neurodegeneration would like to thank all the reviewers who have contributed to the journal in Volume 8 (2013).

    Authors: Guojun Bu and Huaxi Xu

    Citation: Molecular Neurodegeneration 2014 9:9

    Content type: Reviewer acknowledgement

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  45. Recent genome-wide association studies (GWAS) of late-onset Alzheimer’s disease (LOAD) have identified single nucleotide polymorphisms (SNPs) which show significant association at the well-known APOE locus and at...

    Authors: Christopher W Medway, Samer Abdul-Hay, Tynickwa Mims, Li Ma, Gina Bisceglio, Fanggeng Zou, Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Joanna Siuda, Zbigniew K Wszolek, Owen A Ross, Minerva Carrasquillo, Dennis W Dickson, Neill Graff-Radford…

    Citation: Molecular Neurodegeneration 2014 9:11

    Content type: Short report

    Published on:

  46. Identification and quantification of fibrillar amyloid in brain using positron emission tomography (PET) imaging and Amyvid™ ([18 F] Amyvid, [18 F] florbetapir, 18 F-AV-45) was recently approved by the US Food an...

    Authors: Effie M Mitsis, Heidi A Bender, Lale Kostakoglu, Josef Machac, Jane Martin, Jennifer L Woehr, Margaret C Sewell, Amy Aloysi, Martin A Goldstein, Clara Li, Mary Sano and Sam Gandy

    Citation: Molecular Neurodegeneration 2014 9:10

    Content type: Research article

    Published on: