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  1. Alzheimer disease (AD) is a disease of lost memories. Mushroom postsynaptic spines play a key role in memory storage, and loss of mushroom spines has been proposed to be linked to memory loss in AD. Generation...

    Authors: Elena Popugaeva, Ekaterina Pchitskaya, Anastasiya Speshilova, Sergey Alexandrov, Hua Zhang, Olga Vlasova and Ilya Bezprozvanny

    Citation: Molecular Neurodegeneration 2015 10:37

    Content type: Research article

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  2. Previous studies have demonstrated that the trafficking defects of Nav1.1/Nav1.2 are involved in the dementia pathophysiology. However, the detailed mechanisms are not fully understood. Moreover, whether the i...

    Authors: Li-Hua Sun, Mei-Ling Yan, Xue-Ling Hu, Li-Wei Peng, Hui Che, Ya-Nan Bao, Fei Guo, Tong Liu, Xin Chen, Rong Zhang, Tao Ban, Ning Wang, Huai-Lei Liu, Xu Hou and Jing Ai

    Citation: Molecular Neurodegeneration 2015 10:36

    Content type: Research article

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  3. Animal models are extremely valuable to help us understand the pathogenesis of neurodegenerative disorders and to find treatments for them. Since large animals are more like humans than rodents, they make good...

    Authors: Zhuchi Tu, Weili Yang, Sen Yan, Xiangyu Guo and Xiao-Jiang Li

    Citation: Molecular Neurodegeneration 2015 10:35

    Content type: Review

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  4. There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through ...

    Authors: Harun Najib Noristani, Jean Charles Sabourin, Yannick Nicolas Gerber, Marisa Teigell, Andreas Sommacal, Maria dM Vivanco, Markus Weber and Florence Evelyne Perrin

    Citation: Molecular Neurodegeneration 2015 10:34

    Content type: Research article

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  5. Tau hyperphosphorylation plays a critical role in neurodegenerative diseases [EMBO Mol Med. 6:1142-60, 2014; Annu Rev Neurosci. 24:1121-59, 2001]. Recent evidence has shown that Akt is down-regulated in AD [J ...

    Authors: Long Wang, Shanshan Cheng, Zhenyu Yin, Congyu Xu, Shuangshuang Lu, Jinxing Hou, Tingting Yu, Xiaolei Zhu, Xiaoyan Zou, Ying Peng, Yun Xu, Zhongzhou Yang and Guiquan Chen

    Citation: Molecular Neurodegeneration 2015 10:33

    Content type: Short report

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  6. Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is pathologically characterized by loss of dopaminergic neurons from the substantia nigra, the presence of aggregated α-synuclein (αS) ...

    Authors: Nicola J. Rutherford, Amanda N. Sacino, Mieu Brooks, Carolina Ceballos-Diaz, Thomas B. Ladd, Jasie K. Howard, Todd E. Golde and Benoit I. Giasson

    Citation: Molecular Neurodegeneration 2015 10:32

    Content type: Research Article

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  7. Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, prot...

    Authors: Vivek Gautam, Carla D’Avanzo, Oksana Berezovska, Rudolph E. Tanzi and Dora M. Kovacs

    Citation: Molecular Neurodegeneration 2015 10:31

    Content type: Research article

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  8. The clusterin (CLU) gene has been identified as an important risk locus for Alzheimer’s disease (AD). Although the actual risk–increasing polymorphisms at this locus remain to be identified, we previously observe...

    Authors: Karolien Bettens, Steven Vermeulen, Caroline Van Cauwenberghe, Bavo Heeman, Bob Asselbergh, Caroline Robberecht, Sebastiaan Engelborghs, Mathieu Vandenbulcke, Rik Vandenberghe, Peter Paul De Deyn, Marc Cruts, Christine Van Broeckhoven and Kristel Sleegers

    Citation: Molecular Neurodegeneration 2015 10:30

    Content type: Research article

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  9. Amyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer’s disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest. γ-Secretase modulators (GS...

    Authors: Joo In Jung, Ashleigh R. Price, Thomas B. Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A. Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H. Koo, Gideon Shapiro, Kevin M. Felsenstein and Todd E. Golde

    Citation: Molecular Neurodegeneration 2015 10:29

    Content type: Research article

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  10. The number of known pathologies involving deregulated Tau expression/metabolism is increasing. Indeed, in addition to tauopathies, which comprise approximately 30 diseases characterized by neuronal aggregation...

    Authors: Marie-Laure Caillet-Boudin, Luc Buée, Nicolas Sergeant and Bruno Lefebvre

    Citation: Molecular Neurodegeneration 2015 10:28

    Content type: Review

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  11. Alzheimer’s disease (AD) underlies dementia for millions of people worldwide, and its occurrence is set to double in the next 20 years. Currently, approved drugs for treating AD only marginally ameliorate cogn...

    Authors: G. O’Neal-Moffitt, V. Delic, P. C. Bradshaw and J. Olcese

    Citation: Molecular Neurodegeneration 2015 10:27

    Content type: Research article

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  12. Autophagy is thought to play a pivotal role in the pathophysiology of Parkinson’s disease, but little is known about how genes linked to PD affect autophagy in the context of aging. We generated lines of C. el...

    Authors: Shamol Saha, Peter E. A. Ash, Vivek Gowda, Liqun Liu, Orian Shirihai and Benjamin Wolozin

    Citation: Molecular Neurodegeneration 2015 10:26

    Content type: Research article

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  13. UBQLN2 mutations have recently been associated with familial forms of amyotrophic lateral sclerosis (ALS) and ALS-dementia. UBQLN2 encodes for ubiquilin-2, a member of the ubiquitin-li...

    Authors: Carolina Ceballos-Diaz, Awilda M. Rosario, Hyo-Jin Park, Paramita Chakrabarty, Amanda Sacino, Pedro E. Cruz, Zoe Siemienski, Nicolas Lara, Corey Moran, Natalia Ravelo, Todd E. Golde and Nikolaus R. McFarland

    Citation: Molecular Neurodegeneration 2015 10:25

    Content type: Research article

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  14. Cerebral infarction due to thrombosis leads to the most common type of stroke and a likely cause of age-related cognitive decline and dementia. Endothelial nitric oxide synthase (eNOS) generates NO, which play...

    Authors: Xing-Lin Tan, Yue-Qiang Xue, Tao Ma, Xiaofang Wang, Jing Jing Li, Lubin Lan, Kafait U. Malik, Michael P. McDonald, Alejandro M. Dopico and Francesca-Fang Liao

    Citation: Molecular Neurodegeneration 2015 10:24

    Content type: Research article

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  15. Friedreich ataxia (FRDA) is a progressive inherited neurodegenerative disorder caused by mutation of the FXN gene, resulting in decreased frataxin expression, mitochondrial dysfunction and oxidative stress. A rec...

    Authors: Sara Anjomani Virmouni, Sahar Al-Mahdawi, Chiranjeevi Sandi, Hemad Yasaei, Paola Giunti, Predrag Slijepcevic and Mark A. Pook

    Citation: Molecular Neurodegeneration 2015 10:22

    Content type: Research article

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  16. Huntington disease (HD) is an autosomal dominant neurodegenerative disorder, characterized by motor, psychiatric and cognitive symptoms. HD is caused by a CAG repeat expansion in the first exon of the HTT gene, r...

    Authors: Melvin M Evers, Menno H Schut, Barry A Pepers, Melek Atalar, Martine J van Belzen, Richard LM Faull, Raymund AC Roos and Willeke MC van Roon-Mom

    Citation: Molecular Neurodegeneration 2015 10:21

    Content type: Research article

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  17. Mutations in calcium-responsive transactivator (CREST) encoding gene have been recently linked to ALS. Similar to several proteins implicated in ALS, CREST contains a prion-like domain and was reported to be a...

    Authors: Michail S Kukharsky, Annamaria Quintiero, Taisei Matsumoto, Koji Matsukawa, Haiyan An, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L Buchman and Tatyana A Shelkovnikova

    Citation: Molecular Neurodegeneration 2015 10:20

    Content type: Research article

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  18. TREM2 encodes for triggering receptor expressed on myeloid cells 2 and has rare, coding variants that associate with risk for late-onset Alzheimer’s disease (LOAD) in Caucasians of European and...

    Authors: Sheng Chih Jin, Minerva M Carrasquillo, Bruno A Benitez, Tara Skorupa, David Carrell, Dwani Patel, Sarah Lincoln, Siddharth Krishnan, Michaela Kachadoorian, Christiane Reitz, Richard Mayeux, Thomas S Wingo, James J Lah, Allan I Levey, Jill Murrell, Hugh Hendrie…

    Citation: Molecular Neurodegeneration 2015 10:19

    Content type: Research article

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  19. Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyp...

    Authors: Daniel Sevlever, Fanggeng Zou, Li Ma, Sebastian Carrasquillo, Michael G Crump, Oliver J Culley, Talisha A Hunter, Gina D Bisceglio, Linda Younkin, Mariet Allen, Minerva M Carrasquillo, Sigrid B Sando, Jan O Aasly, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen…

    Citation: Molecular Neurodegeneration 2015 10:18

    Content type: Research article

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    The Erratum to this article has been published in Molecular Neurodegeneration 2015 10:49

  20. Cognitive decline and disease progression in different neurodegenerative diseases typically involves synaptic dysfunction preceding the neuronal loss. The synaptic dysfunction is suggested to be caused by imba...

    Authors: Mikael Marttinen, Kaisa MA Kurkinen, Hilkka Soininen, Annakaisa Haapasalo and Mikko Hiltunen

    Citation: Molecular Neurodegeneration 2015 10:16

    Content type: Review

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  21. Lysosomal dysfunction is thought to be a prominent feature in the pathogenetic events leading to Parkinson’s disease (PD). This view is supported by the evidence that mutations in GBA gene, coding the lysosomal h...

    Authors: Davide Chiasserini, Silvia Paciotti, Paolo Eusebi, Emanuele Persichetti, Anna Tasegian, Marzena Kurzawa-Akanbi, Patrick F Chinnery, Christopher M Morris, Paolo Calabresi, Lucilla Parnetti and Tommaso Beccari

    Citation: Molecular Neurodegeneration 2015 10:15

    Content type: Short report

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  22. Microtubule associated protein tau is the major component of the neurofibrillary tangles (NFTs) found in the brains of patients with Alzheimer’s disease and several other neurodegenerative diseases. Tau mutati...

    Authors: Lixin Song, Sherry X Lu, Xuesong Ouyang, Jerry Melchor, Julie Lee, Giuseppe Terracina, Xiaohai Wang, Lynn Hyde, J Fred Hess, Eric M Parker and Lili Zhang

    Citation: Molecular Neurodegeneration 2015 10:14

    Content type: Research article

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  23. Patients with Alzheimer’s disease (AD) frequently experience disruption of their circadian rhythms, but whether and how circadian clock molecules are perturbed by AD remains unknown. AD is an age-related neuro...

    Authors: Hyundong Song, Minho Moon, Han Kyoung Choe, Dong-Hee Han, Changhwan Jang, Ahbin Kim, Sehyung Cho, Kyungjin Kim and Inhee Mook-Jung

    Citation: Molecular Neurodegeneration 2015 10:13

    Content type: Research article

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  24. CD2-associated protein (CD2AP) is an SH3-containing scaffold adaptor protein which regulates the actin cytoskeleton. Recently, CD2AP was identified as a genetic risk factor for Alzheimer’s disease (AD) by seve...

    Authors: Fan Liao, Hong Jiang, Subhashini Srivatsan, Qingli Xiao, Katheryn B Lefton, Kaoru Yamada, Thomas E Mahan, Jin-Moo Lee, Andrey S Shaw and David M Holtzman

    Citation: Molecular Neurodegeneration 2015 10:12

    Content type: Research article

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  25. A diverse set of neurodegenerative disorders are caused by abnormal extensions of polyglutamine (poly-Q) stretches in various, functionally unrelated proteins. A common feature of these diseases is altered pro...

    Authors: Manuela del Caño-Espinel, Judith R Acebes, Diego Sanchez and Maria D Ganfornina

    Citation: Molecular Neurodegeneration 2015 10:11

    Content type: Research article

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  26. Multiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-...

    Authors: Markus Mandler, Elvira Valera, Edward Rockenstein, Michael Mante, Harald Weninger, Christina Patrick, Anthony Adame, Sabine Schmidhuber, Radmila Santic, Achim Schneeberger, Walter Schmidt, Frank Mattner and Eliezer Masliah

    Citation: Molecular Neurodegeneration 2015 10:10

    Content type: Research article

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  27. The fruitfly compound eye has been broadly used as a model for neurodegenerative diseases. Classical quantitative techniques to estimate the degeneration level of an eye under certain experimental conditions r...

    Authors: Sergio Diez-Hermano, Jorge Valero, Cristina Rueda, Maria D Ganfornina and Diego Sanchez

    Citation: Molecular Neurodegeneration 2015 10:9

    Content type: Methodology

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  28. Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson’s disease (PD). A novel H50Q mutation of aSyn, re...

    Authors: Wei Xiang, Stefanie Menges, Johannes CM Schlachetzki, Holger Meixner, Anna-Carin Hoffmann, Ursula Schlötzer-Schrehardt, Cord-Michael Becker, Jürgen Winkler and Jochen Klucken

    Citation: Molecular Neurodegeneration 2015 10:8

    Content type: Research article

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  29. Alzheimer’s disease (AD) causes progressive loss of memory and cognition, exacerbated by APOE4, the greatest genetic risk factor for AD. One proposed mechanism for apolipoprotein E (apoE) effects on cognition is ...

    Authors: De-shan Liu, Xiao-dong Pan, Jing Zhang, Hui Shen, Nicole C Collins, Arron M Cole, Kevin P Koster, Manel Ben Aissa, Xiao-man Dai, Meng Zhou, Leon M Tai, Yuan-gui Zhu, Mary Jo LaDu and Xiao-chun Chen

    Citation: Molecular Neurodegeneration 2015 10:7

    Content type: Research article

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  30. Human apolipoprotein E (apoE) exists in three major isoforms: apoE2, apoE3 and apoE4. In the brain, apoE is produced mostly by astrocytes and transports cholesterol to neurons via apoE receptors. Among the gen...

    Authors: Jin Hu, Chia-Chen Liu, Xiao-Fen Chen, Yun-wu Zhang, Huaxi Xu and Guojun Bu

    Citation: Molecular Neurodegeneration 2015 10:6

    Content type: Research article

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  31. Compelling evidence suggests that inhibition of the complex I of the electron transport chain and elevated oxidative stress are the earliest events during the pathogenesis of Parkinson’s disease (PD). Therefor...

    Authors: Yupin Chen, Dong-qi Zhang, Zhong Liao, Bin Wang, Suzhen Gong, Chuang Wang, Ming-zi Zhang, Guo-hua Wang, Huaibin Cai, Francesca-Fang Liao and Jiang-ping Xu

    Citation: Molecular Neurodegeneration 2015 10:4

    Content type: Research article

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  32. Toll-like receptors (TLR) constitute a highly conserved class of receptors through which the innate immune system responds to both pathogen- and host-derived factors. Although TLRs are involved in a wide range...

    Authors: Karen Rosenberger, Paul Dembny, Katja Derkow, Odilo Engel, Christina Krüger, Susanne A Wolf, Helmut Kettenmann, Eckart Schott, Andreas Meisel and Seija Lehnardt

    Citation: Molecular Neurodegeneration 2015 10:5

    Content type: Research article

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  33. Ubiquitin-specific protease 14 (USP14) is one of three proteasome-associated deubiquitinating enzymes that remove ubiquitin from proteasomal substrates prior to their degradation. In vitro evidence suggests that ...

    Authors: Jada H Vaden, Bula J Bhattacharyya, Ping-Chung Chen, Jennifer A Watson, Andrea G Marshall, Scott E Phillips, Julie A Wilson, Gwendalyn D King, Richard J Miller and Scott M Wilson

    Citation: Molecular Neurodegeneration 2015 10:3

    Content type: Research article

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  34. Soluble fragments of the amyloid precursor protein (APP) generated by α- and β-secretases, sAPPα and sAPPβ, have been postulated as promising new cerebrospinal fluid (CSF) biomarkers for the clinical diagnosis...

    Authors: Inmaculada Cuchillo-Ibañez, Inmaculada Lopez-Font, Alba Boix-Amorós, Gunnar Brinkmalm, Kaj Blennow, Jose-Luis Molinuevo and Javier Sáez-Valero

    Citation: Molecular Neurodegeneration 2015 10:2

    Content type: Research article

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  35. The β-secretase, BACE1, cleaves APP to initiate generation of the β-amyloid peptide, Aβ, that comprises amyloid plaques in Alzheimer’s disease (AD). Reducing BACE1 activity is an attractive therapeutic approac...

    Authors: Katherine R Sadleir, William A Eimer, Sarah L Cole and Robert Vassar

    Citation: Molecular Neurodegeneration 2015 10:1

    Content type: Research article

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  36. Alzheimer’s disease (AD) is a neurodegenerative disorder in which the amyloid-β (Aβ) oligomers are a key factor in synaptic impairment and in spatial memory decline associated with neuronal dysfunction. This i...

    Authors: Felipe G Serrano, Cheril Tapia-Rojas, Francisco J Carvajal, Juan Hancke, Waldo Cerpa and Nibaldo C Inestrosa

    Citation: Molecular Neurodegeneration 2014 9:61

    Content type: Research article

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  37. It is suspected that excess of brain cholesterol plays a role in Alzheimer’s disease (AD). Membrane-associated cholesterol was shown to be increased in the brain of individuals with sporadic AD and to correlat...

    Authors: Catherine Marquer, Jeanne Laine, Luce Dauphinot, Linda Hanbouch, Camille Lemercier-Neuillet, Nathalie Pierrot, Koen Bossers, Mickael Le, Fabian Corlier, Caroline Benstaali, Frédéric Saudou, Gopal Thinakaran, Nathalie Cartier, Jean-Noël Octave, Charles Duyckaerts and Marie-Claude Potier

    Citation: Molecular Neurodegeneration 2014 9:60

    Content type: Research article

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  38. The presenilin genes were first identified as the site of missense mutations causing early onset autosomal dominant familial Alzheimer's disease. Subsequent work has shown that the presenilin proteins are the ...

    Authors: Yi Li, Christopher Bohm, Roger Dodd, Fusheng Chen, Seema Qamar, Gerold Schmitt-Ulms, Paul E Fraser and Peter H St George-Hyslop

    Citation: Molecular Neurodegeneration 2014 9:59

    Content type: Review

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  39. Host-species specificity of the human immunodeficiency virus (HIV) limits pathobiologic, diagnostic and therapeutic research investigations to humans and non-human primates. The emergence of humanized mice as ...

    Authors: Michael D Boska, Prasanta K Dash, Jaclyn Knibbe, Adrian A Epstein, Sidra P Akhter, Natasha Fields, Robin High, Edward Makarov, Stephen Bonasera, Harris A Gelbard, Larisa Y Poluektova, Howard E Gendelman and Santhi Gorantla

    Citation: Molecular Neurodegeneration 2014 9:58

    Content type: Research article

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  40. Epidemiological evidence suggests that low doses of ionising radiation (≤1.0 Gy) produce persistent alterations in cognition if the exposure occurs at a young age. The mechanisms underlying such alterations ar...

    Authors: Stefan J Kempf, Arianna Casciati, Sonja Buratovic, Dirk Janik, Christine von Toerne, Marius Ueffing, Frauke Neff, Simone Moertl, Bo Stenerlöw, Anna Saran, Michael J Atkinson, Per Eriksson, Simonetta Pazzaglia and Soile Tapio

    Citation: Molecular Neurodegeneration 2014 9:57

    Content type: Research article

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  41. Understanding how inflammation causes neuronal damage is of paramount importance in multiple sclerosis (MS) and in other neurodegenerative diseases. Here we addressed the role of the apoptotic cascade in the s...

    Authors: Silvia Rossi, Caterina Motta, Valeria Studer, Giulia Macchiarulo, Elisabetta Volpe, Francesca Barbieri, Gabriella Ruocco, Fabio Buttari, Annamaria Finardi, Raffaele Mancino, Sagit Weiss, Luca Battistini, Gianvito Martino, Roberto Furlan, Jelena Drulovic and Diego Centonze

    Citation: Molecular Neurodegeneration 2014 9:56

    Content type: Research article

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  42. Traumatic brain injury (TBI) is a major health care concern that currently lacks any effective treatment. Despite promising outcomes from many preclinical studies, clinical evaluations have failed to identify ...

    Authors: Dhananjay R Namjoshi, Wai Hang Cheng, Kurt A McInnes, Kris M Martens, Michael Carr, Anna Wilkinson, Jianjia Fan, Jerome Robert, Arooj Hayat, Peter A Cripton and Cheryl L Wellington

    Citation: Molecular Neurodegeneration 2014 9:55

    Content type: Research article

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  43. Recent epidemiological evidence suggests that modifying lifestyle by increasing physical activity could be a non-pharmacological approach to improving symptoms and slowing disease progression in Alzheimer’s di...

    Authors: Odochi Ohia-Nwoko, Saghi Montazari, Yuen-Sum Lau and Jason L Eriksen

    Citation: Molecular Neurodegeneration 2014 9:54

    Content type: Research article

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  44. Synaptic degeneration is an early pathogenic event in Alzheimer’s disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be hi...

    Authors: Ann Brinkmalm, Gunnar Brinkmalm, William G Honer, Lutz Frölich, Lucrezia Hausner, Lennart Minthon, Oskar Hansson, Anders Wallin, Henrik Zetterberg, Kaj Blennow and Annika Öhrfelt

    Citation: Molecular Neurodegeneration 2014 9:53

    Content type: Research article

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  45. The relationship between the pathogenic amyloid β-peptide species Aβ1–42 and tau pathology has been well studied and suggests that Aβ1–42 can accelerate tau pathology in vitro and in vivo. The manners if any i...

    Authors: Xiaoyan Hu, Xiaoling Li, Mingrui Zhao, Andrew Gottesdiener, Wenjie Luo and Steven Paul

    Citation: Molecular Neurodegeneration 2014 9:52

    Content type: Research article

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  46. The amyloid cascade hypothesis has been the prevailing hypothesis in Alzheimer’s Disease research, although the final and most wanted proof i.e. fully successful anti-amyloid clinical trials in patients, is st...

    Authors: Ilie-Cosmin Stancu, Bruno Vasconcelos, Dick Terwel and Ilse Dewachter

    Citation: Molecular Neurodegeneration 2014 9:51

    Content type: Review

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  47. Mouse models are used in the study of human disease. Despite well-known homologies, the difference in immune response between mice and humans impacts the application of data derived from mice to human disease ...

    Authors: Michael D Hoos, Michael P Vitek, Lisa A Ridnour, Joan Wilson, Marilyn Jansen, Angela Everhart, David A Wink and Carol A Colton

    Citation: Molecular Neurodegeneration 2014 9:50

    Content type: Research article

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  48. In the recent years, a role of the immune system in Huntington’s disease (HD) is increasingly recognized. Here we investigate the presence of T cell activating auto-antibodies against angiotensin II type 1 rec...

    Authors: De-Hyung Lee, Harald Heidecke, Alexandra Schröder, Friedemann Paul, Rolf Wachter, Rainer Hoffmann, Gisa Ellrichmann, Duska Dragun, Anne Waschbisch, Johannes Stegbauer, Peter Klotz, Ralf Gold, Ralf Dechend, Dominik N Müller, Carsten Saft and Ralf A Linker

    Citation: Molecular Neurodegeneration 2014 9:49

    Content type: Research article

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  49. Alzheimer’s disease (AD) is a devastating disease characterized by synaptic and neuronal loss in the elderly. Compelling evidence suggests that soluble amyloid-β peptide (Aβ) oligomers induce synaptic loss in ...

    Authors: Shichun Tu, Shu-ichi Okamoto, Stuart A Lipton and Huaxi Xu

    Citation: Molecular Neurodegeneration 2014 9:48

    Content type: Review

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