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Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging

Increasing evidence indicates that neuroinflammation is a critical factor contributing to the progression of various neurodegenerative diseases. The IKK/NF-κB signalling system is a central regulator of inflam...

Authors: Ayesha Maqbool, Michael Lattke, Thomas Wirth and Bernd Baumann

Citation: Molecular Neurodegeneration 2013 8:40

Content type: Research article Published on: 12 October 2013
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Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1

Authors: Sarah Pickles, Laurie Destroismaisons, Sarah Peyrard, Sarah Cadot, Guy Rouleau, Robert Brown Jr., Jean-Pierre Julien, Nathalie Arbour and Christine Vande Velde

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P70

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Monoamine oxidase B is associated with γ-secretase in cultured neurons and in brain

Authors: Sophia Schedin Weiss, Birgitta Wiehager, Bengt Winblad, Susanne Frykman and Lars Tjernberg

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P69

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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p53-mediated disruption of FIP200 function cause autophagic dysregulation in a SCA7 polyglutamine disease model

Authors: Xin Yu, Andrés Muñoz Alarcón, Abiodun Ajayi, Kristin Webling, Anne Steinhof, Ülo Langel and Anna-Lena Ström

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P68

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Insulin resistance and obesity: how do they affect tau pathology?

Authors: Maud Gratuze, Noura El Khoury, Maya DicklerI, Marie-Amélie Papon, Carl Julien, François Marcouiller, Françoise Morin and Emmanuel Planel

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P67

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model

Authors: Aamir Nazir and Pooja Jadiya

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P65

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Misfolding and interactions of Aß proteins: Insight from single molecule experiments and computational analyses

Authors: Lv Zhengjian, Yuliang Zhang, Alexey Krasnoslobodsev, Robin Roychaudhuri, Margaret Condron, David Teplow, Sandor Lovas, Luda Shlyakhtenko and Yuri Lyubchenko

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P64

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse

Authors: Inger Lauritzen, Raphaelle Pardossi-Piquard, Charlotte Druon, Elizabeth Brigham, Daniel Abraham, Sébatien Ranaldi, Linda Chami, Julie Dunys and Fréderic Checler

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P63

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Early hippocampal synaptic plasticity and episodic like-memory deficits in a transgenic mouse model of Alzheimer disease - involvment of corticosterone

Authors: Fabien Lanté, Magda Chafai, Elisabeth Raymond, Ana Rita Salgueiro Peirera, Ingrid Bethus and Helene Marie

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P62

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Tau-Hsp70 interaction on the single molecule level

Authors: Franziska Kundel, Magnus Kjaergaard, Sarah Shammas, Sophie Jackson and David Klenerman

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P61

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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A familial FTD associated with C9orf72 repeat expansion and dysplastic gangliocytoma

Authors: Mia Kero, Raffaele Ferrari, Kin Mok, Anders Paetau, Pentti J Tienari, Olli Tynninen, John Hardy, Parastoo Momeni, Auli Verkkoniemi-Ahola and Liisa Myllykangas

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P60

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Structure-function-relationship of the APP-E1-domain

Authors: Sandra Hoefgen, Sven O Dahms, Dirk Roeser and Manuel E Than

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P59

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Late neurodegeneration in the Tau transgenic mouse model rTg4510

Authors: Lone Helboe and Christiane Volbracht

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P58

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Tauopathy-induced retinal dysfunction in the P301S mutant human tau transgenic mouse

Authors: Nadia Mazzaro, Erica Barini, Michel Goedert, Maria Grazia Spillantini, Paolo Medini and Laura Gasparini

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P57

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Parkin acts as a transcription factor modulating presenilin-1 and presenilin-2 promoter transactivations

Authors: Eric Duplan, Jean Sévalle, Julien Viotti, Thomas Goiran, Charlotte Bauer, Paul Renbaum, Ephrat Levy-Lahad, Clément A Gautier, Olga Corti, Nathalie Leroudier, Frédéric Checler and Cristine Alves da Costa

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P56

Content type: Poster presentation Published on: 4 October 2013

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The overall structure of the multi-domain amyloid precursor protein

Authors: Ina Coburger, Sven O Dahms and Manuel E Than

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P55

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Leaky Ryanodine receptors increases Amyloid-beta load and induces memory impairments in Tg2576 mouse model of Alzheimer disease

Authors: Bénédicte Oulès, Dolores Del Prete, Barbara Greco, Xuexin Zhang, Inger Lauritzen, Mohamed Trebak, Fabio Benfenati, Frédéric Checler and Mounia Chami

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P54

Content type: Poster presentation Published on: 4 October 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration

Epidemiological and molecular findings suggest a relationship between Alzheimer’s disease (AD) and dyslipidemia, although the nature of this association is not well understood.

Authors: Rahul S Desikan, Wesley K Thompson, Dominic Holland, Christopher P Hess, James B Brewer, Henrik Zetterberg, Kaj Blennow, Ole A Andreassen, Linda K McEvoy, Bradley T Hyman and Anders M Dale

Citation: Molecular Neurodegeneration 2013 8:39

Content type: Research article Published on: 2 October 2013
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Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics

Mitochondrial quality control is fundamental to all neurodegenerative diseases, including the most prominent ones, Alzheimer’s Disease and Parkinsonism. It is accomplished by mitochondrial network dynamics – c...

Authors: Marcel V Alavi and Nico Fuhrmann

Citation: Molecular Neurodegeneration 2013 8:32

Content type: Review Published on: 25 September 2013
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Generation and characterization of individual-specific induced pluripotent cells from patient-derived lymphoblastoid cell lines

Authors: Shadaan Zulfiqar, Radhika Menon, Tara Atmaram, Meera Purushottam, Matthew Varghese, Sanjeev Jain, Mitradas Panicker and Odity Mukherjee

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P53

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Ataxia-telangiectasia paradoxes: spotlight on post-zygotic chromosome instability in the brain and its contribution to neurodegeneration pathways

Authors: Yuri Yurov, Svetlana Vorsanova, Thomas Liehr and Ivan Yurov

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P51

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Histone deacetylase inhibition leads to neuroprotection through regulation on glial function

Authors: Xuefei Wu, Shao Li, Qiong Wu, Yan Peng, Deqin Yu, Hecheng Wang, Dehua Chui and Jie Zhao

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P49

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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A driver or a passenger? D421-caspase cleaved tau is associated with aggregated and insoluble tau

Authors: Yolanda Gibson, Katya Garn, Clare Hardy, Manuela Piarulli, Sarah Glover, Mark Ward, Emily McNaughton, Michael Hutton, Michael O’Neill and Joanna Wolak

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P47

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Cysteine-rich domain of scavenger receptor Al modulates the efficacy of surface targeting and mediates internalization of oligomeric beta amyloid

Authors: Huey-Jen Tsay

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P43

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease

Authors: Amantha Thathiah, Katrien Horre, An Snellinx, Elke Vandewyer, Yunhong Huang, Marta Ciesielska, Gerdien De Kloe, Sebastian Munck and Bart De Strooper

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P41

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Tau-focused therapy and tau transmission: Implications for Alzheimer’s Disease and related tauopathies

Authors: John Q Trojanowski

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O37

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Analysis of the protein network of cholesterol homeostasis maintenance in a mouse model of Alzheimer’s disease

Authors: Marco Segatto, Pamela Rosso, Sandra Moreno and Valentina Pallottini

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P37

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Abeta is prerequisite, but insufficient to cause tau phosphorylation in vivo: tau phosphorylation in APP mice by diabetes

Authors: Naoyuki Sato

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P35

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Identifying dominant modifiers of mutant FUS toxicity in vivo

Authors: J Gavin Daigle, Nicholas A Lanson, Ian Casci, John Monaghan, Charles Nichols, Dimitri Kryndushkin, Frank Shewmaker and Udai Pandey

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O33

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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LRP1 plays a major role in the amyloid-β clearance in microglia

Authors: Aurelie N’Songo, Takahisa Kanekiyo and Guojun Bu

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P33

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism

Authors: François Mouton-Liger, Anne-Sophie Rebillat, Sarah Gourmaud, Audrey Leguen, Claire Paquet, Laurent Pradier, Thomas Rooney and Jacques Hugon

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P31

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Amyloid-β drives a type-1 interferon mediated neuro-inflammatory response in Alzheimer’s disease

Authors: Myles Minter, Juliet Taylor, Moses Zhang, Paul Adlard and Peter Crack

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P29

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain

Authors: Aurélien Lathuilière, Stéphanie Papin, Matthias Cacquevel, Paolo Paganetti, Andreas Muhs, Graham Knott, Bernard Schneider and Patrick Aebischer

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P27

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Transmission of alpha-synuclein in Parkinson’s disease

Authors: Virginia M-Y Lee

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O25

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Analysis of TDP-43 and its binding partners in neurodegenerative diseases

Authors: Wejdan Kattuah, Claire Troakes, Tibor Hortobagyi, Boris Rogelj and Christopher Shaw

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P23

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Prion-like aspects of cerebral amyloidosis

Authors: Mathias Jucker, Lan Ye and Sarah Fritschi

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O21

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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The role of SorLA in neurotrophic activity and complex behavior

Authors: Simon Glerup, Mart Saarma and Anders Nykjaer

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P19

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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In situstudies of protein aggregation kinetics with multiparametric and superresolution imaging

Authors: Gabriele Kaminski Schierle, Claire Michel, Eric Rees, Dorothea Pinotsi and Clemens Kaminski

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O15

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Platelet BACE1 levels as a possible biomarker for Alzheimer’s disease

Authors: Boris Decourt, Aaron Walker, Amanda Gonzales, Michael Malek-Ahmadi, Carolyn Liesback, Kathryn Davis, Christine Belden, Sandra Jacobson and Marwan Sabbagh

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P14

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Regulation of mitochondrial function by PINK1, Parkin and DJ-1

Authors: Emilie Giaime and Jie Shen

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O13

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Using Caenorhabditis elegans to fight human neurodegenerative diseases

Authors: Xi Chen, Brian Kraemer, Jeff Barclay, Robert Burgoyne and Alan Morgan

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P12

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Endogenous and exogenous regulation of gamma-secretase

Authors: Yueming Li

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O10

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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The pro-neurotrophin receptor sortilin is a major neuronal APOE receptor for catabolism of amyloid-β peptide in the brain

Authors: Anne-Sophie Carlo, Camilla Gustafsen, Guido Mastrobuoni, Morten Nielsen, Stefan Kempa, Claus Munck Petersen and Thomas Willnow

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P10

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Regulation of dynamic BACE1 trafficking in neurons

Authors: Virginie Buggia-Prévot, Celia G Fernandez, Sean Riordan, Kulandaivelu S Vetrivel, Vinod Udayar, Aureliane Elie, Margaret Lefkow, Jelita Roseman, Xavier Meckler, Sohinee Bhattacharyya, Manju George, Jack Waters, Vytautas P Bindokas, Angèle T Parent, Lawrence Rajendran, Hamid Band…

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O8

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Development of a paradigm to investigate mechanisms of divided and selective attention impairment in the rodent models of Alzheimer’s disease

Authors: Gytis Baranauskas, Natasa Svirskiene and Gytis Svirskis

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P6

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase

Authors: Stefan Lichtenthaler

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O6

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage in the response to excitotoxic injury

Authors: Emanuela Angelucci, Sandra Moreno, Marcello D’Amelio, Roberta Nardacci, Francesco Cecconi, Paolo Mariottini and Manuela Cervelli

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P4

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Role of APP in neuronal function

Authors: Hui Zheng

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O4

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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The composition of the γ-secretase complex defines its Aβ product profile

Authors: Hermien Acx, Lucía Chávez Gutiérrez, Lutgarde Serneels and Bart De Strooper

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P2

Content type: Poster presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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Decoding Alzheimer’s in the age of genome-wide analyses

Authors: Rudolph E Tanzi

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O1

Content type: Oral presentation Published on: 13 September 2013

This article is part of a Supplement: Volume 8 Supplement 1
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