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  2. Aberrant hyperphosphorylation of tau protein has been implicated in a variety of neurodegenerative disorders. Although a number of protein kinases have been shown to phosphorylate tau in vitro and in vivo, the mo...

    Authors: Xue Zhang, Yun-wu Zhang, Shijie Liu, Ayelen Bulloj, Gary G Tong, Zhuohua Zhang, Francesca-Fang Liao and Huaxi Xu

    Citation: Molecular Neurodegeneration 2006 1:7

    Content type: Research article

    Published on:

  3. The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias. Here, we have investigated the effects of a series of commercially availa...

    Authors: Chad A Dickey, Peter Ash, Natalia Klosak, Wing C Lee, Leonard Petrucelli, Michael Hutton and Christopher B Eckman

    Citation: Molecular Neurodegeneration 2006 1:6

    Content type: Research article

    Published on:

  4. The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains...

    Authors: Hui Zheng and Edward H Koo

    Citation: Molecular Neurodegeneration 2006 1:5

    Content type: Review

    Published on:

  5. Mutations in PSEN1 and PSEN2 genes account for the majority of cases of early-onset familial Alzheimer disease. Since the first prediction of a genetic link between PSEN1 and PSEN2 with Alzheimer's disease, many ...

    Authors: Kulandaivelu S Vetrivel, Yun-wu Zhang, Huaxi Xu and Gopal Thinakaran

    Citation: Molecular Neurodegeneration 2006 1:4

    Content type: Review

    Published on:

  6. The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been...

    Authors: Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah and Todd E Golde

    Citation: Molecular Neurodegeneration 2006 1:3

    Content type: Research article

    Published on:

  7. Presenilin-dependent γ-secretase cleavage of several transmembrane proteins, including amyloid-β precursor protein and Notch, mediates the intramembrane proteolysis to liberate their intracellular domains that...

    Authors: Taisuke Tomita, Sayaka Tanaka, Yuichi Morohashi and Takeshi Iwatsubo

    Citation: Molecular Neurodegeneration 2006 1:2

    Content type: Research article

    Published on:

  8. Despite the existence of several scientific journals that publish research papers and reviews related to neurodegenerative diseases, a journal specifically devoted to the molecular and cellular aspects of dise...

    Authors: Guojun Bu, Huaxi Xu and Todd E Golde

    Citation: Molecular Neurodegeneration 2006 1:1

    Content type: Editorial

    Published on:

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  • ISSN: 1750-1326 (electronic)

Molecular Neurodegeneration

ISSN: 1750-1326

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