From: Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1
Cell Line
Transfected PS1 Constructs
Ratio of Aβ42/Aβ
H125.3-16
PS1
0.082 ± 0.022
"
PS1-D385TG
0.261 ± 0.029**
PS1-D385TA
0.212 ± 0.007**
PS1-D257TA/D385TG
0.186 ± 0.010**
PS1- D257TG/D385TA
0.171 ± 0.005**