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  1. Research article

    Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

    Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whe...

    Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson and Paramita Chakrabarty

    Molecular Neurodegeneration 2017 12:40

    Published on: 29 May 2017

  2. Review

    Endoplasmic reticulum stress and inflammation in the central nervous system

    Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegene...

    Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sánchez and Gordon P. Meares

    Molecular Neurodegeneration 2017 12:42

    Published on: 25 May 2017

  3. Research article

    Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

    Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and re...

    Takashi Miyamoto, Liana Stein, Reuben Thomas, Biljana Djukic, Praveen Taneja, Joseph Knox, Keith Vossel and Lennart Mucke

    Molecular Neurodegeneration 2017 12:41

    Published on: 19 May 2017

  4. Research article

    Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

    Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post...

    Nicholas B. Hastings, Xiaohai Wang, Lixin Song, Brent D. Butts, Diane Grotz, Richard Hargreaves, J. Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X. Lu, Maureen Maguire, Veeravan Mahadomrongkul…

    Molecular Neurodegeneration 2017 12:39

    Published on: 18 May 2017

  5. Methodology

    Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129

    Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, the current H129 derived tracers...

    Wen-Bo Zeng, Hai-Fei Jiang, Ya-Dong Gang, Yi-Ge Song, Zhang-Zhou Shen, Hong Yang, Xiao Dong, Yong-Lu Tian, Rong-Jun Ni, Yaping Liu, Na Tang, Xinyan Li, Xuan Jiang, Ding Gao, Michelle Androulakis, Xiao-Bin He…

    Molecular Neurodegeneration 2017 12:38

    Published on: 12 May 2017

  6. Commentary

    Diurnal oscillation of CSF Aβ and other AD biomarkers

    To assess stages of Alzheimer's disease (AD) pathogenesis and the efficacy of drugs during clinical trials, there has been immense interest in the field to establish baseline cerebrospinal fluid (CSF) concentr...

    Brendan P. Lucey, Anne M. Fagan, David M. Holtzman, John C. Morris and Randall J. Bateman

    Molecular Neurodegeneration 2017 12:36

    Published on: 8 May 2017

  7. Research article

    Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

    Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused...

    Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M. Ravits, Anatoly Starkov and Giovanni Manfredi

    Molecular Neurodegeneration 2017 12:37

    Published on: 8 May 2017

  8. Research article

    Dioxins and related environmental contaminants increase TDP-43 levels

    Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition that is characterized by progressive loss of motor neurons and the accumulation of aggregated TAR DNA Binding Protein-43 (TDP-4...

    Peter E. A. Ash, Elizabeth A. Stanford, Ali Al Abdulatif, Alejandra Ramirez-Cardenas, Heather I. Ballance, Samantha Boudeau, Amanda Jeh, James M. Murithi, Yorghos Tripodis, George J. Murphy, David H. Sherr and Benjamin Wolozin

    Molecular Neurodegeneration 2017 12:35

    Published on: 5 May 2017

  9. Research article

    Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

    The experience from clinical trials indicates that anti-Aβ immunotherapy could be effective in early/pre-clinical stages of AD, whereas at the late stages promoting the clearing of Aβ alone may be insufficient...

    Michael G. Agadjanyan, Karen Zagorski, Irina Petrushina, Hayk Davtyan, Konstantin Kazarian, Maxim Antonenko, Joy Davis, Charles Bon, Mathew Blurton-Jones, David H. Cribbs and Anahit Ghochikyan

    Molecular Neurodegeneration 2017 12:33

    Published on: 5 May 2017

  10. Research article

    Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

    The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer’s disease (AD). In addition to histone acetyltransferases (HATs) and histone deacetylases (HDACs), inhibitor of ac...

    Gao-Shang Chai, Qiong Feng, Zhi-Hao Wang, Yu Hu, Dong-Sheng Sun, Xiao-Guang Li, Dan Ke, Hong-Lian Li, Gong-Ping Liu and Jian-Zhi Wang

    Molecular Neurodegeneration 2017 12:34

    Published on: 4 May 2017

  11. Research article

    Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

    Chemokine signalling is required for the homing of leukocytes during retinal inflammation, and is associated with pathogenesis of diseases such as age-related macular degeneration (AMD). Here, we explore the r...

    Riccardo Natoli, Nilisha Fernando, Michele Madigan, Joshua A. Chu-Tan, Krisztina Valter, Jan Provis and Matt Rutar

    Molecular Neurodegeneration 2017 12:31

    Published on: 24 April 2017

  12. Research article

    Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model

    Microglia mediate amyloid-beta peptide (Aβ)-induced neuroinflammation, which is one of the key events in the pathogenesis of Alzheimer’s disease (AD). Decoy receptor 3 (DcR3)/TNFRSF6B is a pleiotropic immunomo...

    Yi-Ling Liu, Wei-Ting Chen, Yu-Yi Lin, Po-Hung Lu, Shie-Liang Hsieh and Irene Han-Juo Cheng

    Molecular Neurodegeneration 2017 12:30

    Published on: 24 April 2017

  13. Research article

    The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

    Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a...

    Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek and Wolfdieter Springer

    Molecular Neurodegeneration 2017 12:32

    Published on: 24 April 2017

  14. Research article

    Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

    Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson’s Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates...

    Aitor Martinez, Benoit Lectez, Juanma Ramirez, Oliver Popp, James D. Sutherland, Sylvie Urbé, Gunnar Dittmar, Michael J. Clague and Ugo Mayor

    Molecular Neurodegeneration 2017 12:29

    Published on: 11 April 2017

  15. Research article

    Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

    Amyloid-β oligomers (oAβ) are thought to mediate neurotoxicity in Alzheimer’s disease (AD), and previous studies in AD transgenic mice suggest that calcium dysregulation may contribute to these pathological ef...

    Michal Arbel-Ornath, Eloise Hudry, Josiah R. Boivin, Tadafumi Hashimoto, Shuko Takeda, Kishore V. Kuchibhotla, Steven Hou, Carli R. Lattarulo, Arianna M. Belcher, Naomi Shakerdge, Pariss B. Trujillo, Alona Muzikansky, Rebecca A. Betensky, Bradley T. Hyman and Brian J. Bacskai

    Molecular Neurodegeneration 2017 12:27

    Published on: 21 March 2017

  16. Research article

    Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

    FADD (Fas-associated death domain) adaptor is a crucial protein involved in the induction of cell death but also mediates non-apoptotic actions via a phosphorylated form (p-Ser194-FADD). This study investigate...

    Alfredo Ramos-Miguel, Jesús A. García-Sevilla, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer and M. Julia García-Fuster

    Molecular Neurodegeneration 2017 12:26

    Published on: 20 March 2017

  17. Research article

    Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

    The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer’s disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ production by interacting to γ-secretase.

    Francesc X. Guix, Ragna Sannerud, Fedor Berditchevski, Amaia M. Arranz, Katrien Horré, An Snellinx, Amantha Thathiah, Takaomi Saido, Takashi Saito, Sundaresan Rajesh, Michael Overduin, Samir Kumar-Singh, Enrico Radaelli, Nikky Corthout, Julien Colombelli, Sébastien Tosi…

    Molecular Neurodegeneration 2017 12:25

    Published on: 10 March 2017

  18. Research article

    Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

    The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against...

    Prateep Pakavathkumar, Anastasia Noël, Clotilde Lecrux, Agne Tubeleviciute-Aydin, Edith Hamel, Jan-Eric Ahlfors and Andrea C. LeBlanc

    Molecular Neurodegeneration 2017 12:22

    Published on: 28 February 2017

  19. Research article

    Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

    Reduction or inhibition of histone deacetylase 6 (HDAC6) has been shown to rescue memory in mouse models of Alzheimer’s disease (AD) and is recently being considered a possible therapeutic strategy. However, t...

    Heesun Choi, Haeng Jun Kim, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Seung Jae Hyeon, Dong-Sup Lee, Hoon Ryu, Junho Chung and Inhee Mook-Jung

    Molecular Neurodegeneration 2017 12:23

    Published on: 28 February 2017

  20. Research article

    Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

    The ubiquitin-proteasome-system (UPS) is the major intracellular pathway leading to the degradation of unwanted and/or misfolded soluble proteins. This includes proteins regulating cellular survival, synaptic ...

    Tobias Engel, Jaime Martinez-Villarreal, Christine Henke, Eva M. Jimenez-Mateos, Amaya Sanz-Rodriguez, Mariana Alves, Yasmina Hernandez-Santana, Gary P. Brennan, Aidan Kenny, Aoife Campbell, Jose J. Lucas and David C. Henshall

    Molecular Neurodegeneration 2017 12:21

    Published on: 24 February 2017

  21. Research article

    Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

    The ability of oligodendrocyte progenitor cells (OPCs) to give raise to myelin forming cells during developmental myelination, normal adult physiology and post-lesion remyelination in white matter depends on f...

    Camille Leonetti, Richard Macrez, Mathilde Pruvost, Yannick Hommet, Jérémie Bronsard, Antoine Fournier, Maxime Perrigault, Isabel Machin, Denis Vivien, Diego Clemente, Fernando De Castro, Eric Maubert and Fabian Docagne

    Molecular Neurodegeneration 2017 12:20

    Published on: 23 February 2017

  22. Research article

    Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

    Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptide...

    Erik Portelius, Niklas Mattsson, Josef Pannee, Henrik Zetterberg, Magnus Gisslén, Hugo Vanderstichele, Eleni Gkanatsiou, Gabriela A. N. Crespi, Michael W. Parker, Luke A. Miles, Johan Gobom and Kaj Blennow

    Molecular Neurodegeneration 2017 12:18

    Published on: 20 February 2017

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