Figure 2
From: Novel cerebrovascular pathology in mice fed a high cholesterol diet
Vascular pathology in C57BL/6J and LDLR-/- mice fed a high-cholesterol diet. Anti-collagen IV immunoperoxidase-stained microvessels in the hippocampus of one-year old C57BL/6J (A-D), or LDLR-/- mice (E-H) fed low-cholesterol (A, B, E, F), or high-cholesterol (C, D, G, H) diets for 10 months. Mice in the high-cholesterol fed groups (C57BL-HCD and LDLR-HCD) exhibit a mixture of microvessels that are often thinner and irregular (see especially panels C, D) while other microvessels appear enlarged (see especially panels F, H). Scale bar = 50 μm.