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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans

Figure 3

Effect of JAY2-22-33 and JWB1-84-1 on Aβ levels using ELISA. JAY2-22-33 and JWB1-84-1 treatment to N2a neuroblastoma cells significantly reduced secreted amount of Aβ monomers using ELISA (p < 0.05) based on one way ANOVA analysis. Posthoc dunnette test showed that the JAY2-22-33 treatment for 24 hours significantly reduced the levels of secreted Aβ monomers at 0.5 μM (p < 0.01) and 1 μM (p < 0.001). JWB treatment for 24 hours significantly reduced the amount of secreted Aβ monomers at 0.125 μM (p < 0.001), 0.25 μM (p < 0.05), 1 μM (p < 0.001) and 2 μM (p < 0.01). Data were expressed as mean± SEM (N = 3).

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Molecular Neurodegeneration

ISSN: 1750-1326