Table 2 Reactions involving Gsk3β, Aβ and tau

1

GSK3b_p53Binding

GSK3b+p53→

GSK3b_p53

k_binGSK3bp53<#GSK3b><#p53>

2.0E-6 molecule^-1 s^-1

2

GSK3b_p53Release

GSK3b_p53→ GSK3b+p53

k_relGSK3bp53<#GSK3b_p53>

2.0E-3 s^-1

(1)

GSK3b_p53_PBinding

GSK3b+p53_P→

GSK3b_p53_P

k_binGSK3bp53<#GSK3b><#p53_P>

2.0E-6 molecule^-1 s^-1

(2)

GSK3b_p53_PRelease

GSK3b_p53_P→ GSK3b+p53_P

k_relGSK3bp53<#GSK3b_p53_P>

2.0E-3 s^-1

3

Mdm2mRNASynthesis3

GSK3b_p53→

GSK3b_p53+Mdm2mRNA

k_{synMdm2mRNAGSK3bp53}<#GSK3b_p53>

7.0E-4 s^-1

(3)

Mdm2mRNASynthesis4

GSK3b_p53_P→

GSK3b_p53_P+Mdm2mRNA

k_{synMdm2mRNAGSKbp53}<#GSK3b_p53_P>

7.0E-4 s^-1

4

Mdm2GSK3phosphorylation1

Mdm2_p53_Ub4+GSK3b→ Mdm2_P1_p53_Ub4+GSK3b

k_{phosMdm2GSK3b}<#Mdm2_p53_Ub4> <#GSK3b>

5.0E-3 molecule^-1 s^-1

5

Mdm2GSK3phosphorylation2

Mdm2_p53_Ub4+GSK3b_p53 → Mdm2_P1_p53_Ub4 +GSK3b_p53

k_{phosMdm2GSK3bp53}<#Mdm2_p53_Ub4> <#GSK3b_p53>

5.0E-1 molecule^-1 s^-1

(5)

Mdm2GSK3phosphorylation3

Mdm2_p53_Ub4+GSK3b_p53_P→ Mdm2_P1_p53_Ub4+GSK3b_p53_P

k_{phosMdm2GSK3bp53}<#Mdm2_p53_Ub4> <#GSK3b_p53_P>

5.0E-1 molecule^-1 s^-1

6

TauSynthesis

Source→Tau

k _synTau

8.0E-5 molecule s^-1

7

TauProteasomeBinding

Tau+Proteasome→Proteasome_Tau

k _binTauProt <#Tau><#Proteasome>

1.9E-7 molecule^-1 s^-1

8

TauDegradation

Proteasome_Tau→Proteasome

k _degTau <#Proteasome_Tau>

1.0E-2 s^-1

9

TauMTbinding

Tau→MT_Tau

k _binMTTtau <#Tau>

1.0E-1 s^-1

10

TauMTrelease

MT_Tau→Tau

k _relMTTau <#MT_Tau>

1.0E-4 s^-1

11

Tauphosphorylation1

GSK3b_p53+Tau→GSK3b_p53+Tau_P1

k_{phospTauGSK3bp53}<#GSK3b_p53><#Tau>

1.0E-1 molecule^-1 s^-1

(11)

Tauphosphorylation2

GSK3b_p53+Tau_P1→GSK3b_p53+Tau_P2

k_{phospTauGSK3bp53}<#GSK3b_p53> <#Tau_P1>

1.0E-1 molecule^-1 s^-1

(11)

Tauphosphorylation3

GSK3b_p53_P+Tau→GSK3b_p53_P+

Tau_P1

k_{phospTauGSK3bp53}<#GSK3b_p53_P><# Tau>

1.0E-1 molecule^-1 s^-1

(11)

Tauphosphorylation4

GSK3b_p53_P + Tau_P1→GSK3b_p53_P+ Tau_P2

k_{phospTauGSK3bp53}<# GSK3b_p53_P> <#Tau_P1>

1.0E-1 molecule^-1 s^-1

12

Tauphosphorylation5

GSK3b+Tau→GSK3b+Tau_P1

k_{phospTauGSK3b}<#GSK3b><#Tau>

2.0E-4 molecule^-1 s^-1

(12)

Tauphosphorylation6

GSK3b+Tau_P1→GSK3b+Tau_P2

k_{phospTauGSK3b}<#GSK3b><#Tau_P1>

2.0E-4 molecule^-1 s^-1

(13)

Taudephosphorylation1

Tau_P2+PP1→Tau_P1+PP1

k _dephospTau <#Tau_P2><#PP1>

1.0E-2 molecule^-1 s^-1

14

TauAggregation1

2Tau→2AggTau

k _aggTau <# Tau><#(Tau-1)>/2.0

1.0E-8 molecule^-1 s^-1

(14)

TauAggregation2

Tau+AggTau→2AggTau

k _aggTau <#Tau><#AggTau>

1.0E-8 molecule^-1 s^-1

15

TauP1Aggregation1

2Tau_P1→2AggTau

k_aggTauP1 <#Tau_P1><#(Tau_P1-1)>/2.0

1.0E-8 molecule^-1 s^-1

(15)

TauP1Aggregation2

Tau_P1+AggTau→2AggTau

k_aggTauP1 <# Tau_P1><#AggTau>

1.0E-8 molecule^-1 s^-1

(15)

TauP2Aggregation1

2Tau_P2→2AggTau

k_aggTauP2 <#Tau_P2><# (Tau_P2-1)>/2.0

1.0E-7 molecule^-1 s^-1

(15)

TauP2Aggregation2

Tau_P2 + AggTau→2AggTau

k_aggTauP2 <#Tau_P2><# AggTau>

1.0E-7 molecule^-1 s^-1

16

TangleFormation1

2AggTau→2NFT

k _tangfor <#AggTau><#(AggTau-1)>/2.0

1.0E-3 molecule^-1 s^-1

(16)

TangleFormation2

AggTau+NFT→2NFT

k _tangfor <#AggTau><#NFT>

1.0E-3 molecule^-1 s^-1

17

ProteasomeInhibitionAggTau

AggTau+Proteasome→

AggTau_Proteasome

k _inhibprot <#AggTau><#Proteasome>

1.0E-5 molecule^-1 s^-1

18

Abetaproduction1

GSK3b_p53→Abeta+GSK3b_p53

k _prodAbeta <#GSK3b_p53>

5.0E-5 s^-1

(18)

Abetaproduction2

GSK3b_p53_P→Abeta

+GSK3b_p53_P

k _prodAbeta <#GSK3b_p53_P>

5.0E-5 s^-1

19

AbetaDegradation

Abeta→Sink

k _degAbeta <#Abeta>

1.0E-4 s^-1

20

AbetaAggregation1

2Abeta→AggAbeta

k _aggAbeta <#Abeta><#(Abeta-1)>/2.0

1.0E-8 molecule^-1 s^-1

(20)

AbetaAggregation2

Abeta+AggAbeta→2AggAbeta

k _aggAbeta <#Abeta><#AggAbeta>

1.0E-8 molecule^-1 s^-1

21

AbetaPlaqueFormation1

2AggAbeta→2AbetaPlaque

k _pf <#AggAbeta><#(AggAbeta-1)>/2.0

1.0E-3 molecule^-1 s^-1

(21)

AbetaPlaqueFormation2

AggAbeta+AbetaPlaque→2AbetaPlaque

k _pf <#AggAbeta><#AbetaPlaque>

1.0E-3 molecule^-1 s^-1

22

ProteasomeInhibitionAbeta

AggAbeta+Proteasome→

AggAbeta_Proteasome

k _inhibprot <#AggAbeta><#Proteasome>

1.0E-5 molecule^-1 s^-1

23

p53transcriptionViaAbeta

Abeta→p53_mRNA+Abeta

k_{synp53mRNAAbeta}<#Abeta>

1.0E-5 s^-1

24

AbetaROSproduction1

AggAbeta→AggAbeta + ROS

k _genROSAbeta <#AggAbeta>

1.0E-5 s^-1

24

AbetaROSproduction2

AggAbeta_Proteasome→AggAbeta_Proteasome + ROS

k _genROSAbeta <#AggAbeta_Proteasome>

1.0E-5 s^-1