From: GSK3 and p53 - is there a link in Alzheimer's disease?
No. | Name | Reactants and products | Kinetic lawa | Parameter values | |||
---|---|---|---|---|---|---|---|
25 | p53 synthesis | p53_mRNA→p53+p53_mRNA | ksynp53 <#p53_mRNA> | 7.0E-3 s-1 | |||
26 | p53 Mdm2 binding | p53+Mdm2 → Mdm2_p53 | kbinMdm2p53<#p53><#Mdm2> | 3.0E-3 molecule-1 s-1 | |||
27 | Mdm2_p53 release | Mdm2_p53→p53+Mdm2 | krelMdm2p53 <#Mdm2_p53> | 3.0E-5 s-1 | |||
E1/Ub binding | E1+Ub+ATP→E1_Ub+AMP | kbinE1Ub<#E1><#Ub><#ATP>/(5000 +<#ATP>) | 2.0E-4 molecule-1 s-1 | ||||
E2/Ub binding | E1_Ub+E2→E2_Ub+E1 | kbinE2Ub<#E2><#E1_Ub> | 1.0E-3 molecule-1 s-1 | ||||
28 | p53 ubiquitination | Mdm2_p53+E2_Ub→Mdm2_p53_Ub+E2 | kp53Ub<#Mdm2_p53><#E2_Ub> | 5.0E-5 molecule-1 s-1 | |||
29 | p53 polyubiquitination1 | Mdm2_p53_Ub+E2_Ub→Mdm2_p53_ Ub2+E2 | kp53PolyUb<#Mdm2_p53_Ub><#E2_Ub> | 1.0E-2 molecule-1 s-1 | |||
30 | p53 polyubiquitinationX (X = 2-3) | Mdm2_p53_Ub(X)+E2_Ub→ Mdm2_p53_Ub(X+1)+E2 | kp53PolyUb<#Mdm2_p53_Ub(X)><#E2_Ub> | 1.0E-2 molecule-1 s-1 | |||
p53 de-ubiquitination1 | Mdm2_p53_Ub+p53DUB → Mdm2_p53+p53DUB+Ub | kactDUBp53<#Mdm2_p53_Ub> <#p53DUB> | 1.0E-7 molecule-1 s-1 | ||||
p53 de-ubiquitinationX (X = 2-4) | Mdm2_p53_Ub(X)+p53DUB → Mdm2_p53_Ub(X-1)+p53DUB+Ub | kactDUBp53<#Mdm2_p53_Ub(X)> <#p53DUB> | 1.0E-7 molecule-1 s-1 | ||||
31 | p53 Proteasome binding | Mdm2_P_p53_Ub4+Proteasome→ p53_Ub4_Proteasome+Mdm2 | k binProt <# Mdm2_P_p53_Ub4><#Proteasome> | 2.0E-6 molecule-1 s-1 | |||
32 | p53 degradation | p53_Ub4_Proteasome+ATP→ 4Ub+Proteasome+ADP | kdegp53<#p53_Ub4_Proteasome> <#ATP>/(5000 + <#ATP>) | 1.0E-2 s-1 | |||
33 | Mdm2mRNA synthesis1 | p53→p53+Mdm2_mRNA | ksynMdm2mRNA<#p53> | 5.0E-4 s-1 | |||
(33) | Mdm2mRNA synthesis2 | p53_P→p53_P+Mdm2_mRNA | ksynMdm2mRNA<#p53_P> | 5.0E-4 s-1 | |||
34 | Mdm2 mRNA degradation | Mdm2_mRNA→Sink | kdegMdm2mRNA<#Mdm2_mRNA> | 5.0E-4 s-1 | |||
35 | Mdm2 synthesis | Mdm2_mRNA→Mdm2_mRNA+Mdm2 | ksynMdm2<#Mdm2_mRNA> | 4.95E-4 s-1 | |||
Mdm2 ubiquitinationb | Mdm2+E2_Ub→Mdm2_Ub+E2 | kMdm2Ub<#Mdm2><#E2_Ub> | 4.56E-6 molecule-1 s-1 | ||||
Mdm2 polyubiquitination1c | Mdm2_Ub+E2_Ub→Mdm2_Ub2+E2 | kMdm2PolyUb<#Mdm2_Ub><#E2_Ub> | 4.56E-3 molecule-1 s-1 | ||||
Mdm2 polyubiquitinationXc (X = 2-3) | Mdm2_Ub(X)+E2_Ub→Mdm2_Ub(X+1)+E2 | kMdm2PolyUb<#Mdm2_Ub(X)><#E2_Ub> | 4.56E-3 molecule-1 s-1 | ||||
Mdm2 de-ubiquitination1c | Mdm2_Ub+Mdm2DUB → Mdm2+Mdm2DUB+Ub | kactDUBMdm2<#Mdm2_Ub><#Mdm2DUB> | 1.0E-7 molecule-1 s-1 | ||||
Mdm2 de-ubiquitinationXc (X = 2-4) | Mdm2_Ub(X)+Mdm2DUB → Mdm2_Ub(X-1)+Mdm2DUB+Ub | kactDUBMdm2<#Mdm2_Ub(X)> <#Mdm2DUB> | 1.0E-7 molecule-1 s-1 | ||||
Mdm2 proteasome bindingc | Mdm2_Ub4 + Proteasome→Mdm2_Ub4_Proteasome | k binProt <# Mdm2_Ub4><#Proteasome> | 2.0E-6 molecule-1 s-1 | ||||
Mdm2 degradationc | Mdm2_Ub4_Proteasome+ATP→ 4Ub+Proteasome+ADP | kdegMdm2<#Mdm2_Ub4_Proteasome> <#ATP>/(5000+<#ATP>) | 1.0E-2 molecule-1 s-1 | ||||
36 | ATM activation | damDNA+ATMI→damDNA+ATMA | k actATM <#damDNA><#ATMI> | 1.0E-4 molecule-1 s-1 | |||
37 | ATM inactivation | ATMA → ATMI | k inactATM <#ATMA> | 5.0E-4 s-1 | |||
38 | p53 phosphorylation | p53+ATMA→p53_P+ATMA | kphosp53<#p53><#ATMA> | 2.0E-4 molecule-1 s-1 | |||
39 | p53 dephosphorylation | p53_P→p53 | kdephosp53<#p53_P> | 5.0E-1 s-1 | |||
Mdm2 phosphorylation | Mdm2+ATMA→Mdm2_P+ATMA | kphosMdm2<#Mdm2><#ATMA> | 2.0 molecule-1 s-1 | ||||
Mdm2 de-phosphorylation | Mdm2_P→Mdm2 | kdephosMdm2<#Mdm2_P> | 5.0E-1 s-1 | ||||
40 | p53mRNA synthesis | Source→p53_mRNA | k synp53mRNA | 1.0E-3 molecule s-1 | |||
41 | p53mRNA degradation | p53_mRNA→Sink | kdegp53mRNA<#p53_mRNA> | 1.0E-4 s-1 | |||
42 | DNA damage by IR | IR→damDNA+ IR | k dam <#IR> | 8.0E-2 s-1 | |||
43 | DNA repair | damDNA→Sink | k repair <#damDNA> | 2.0E-5 s-1 | |||
44 | DNA damage by ROS | ROS→damDNA+ROS | k damROS <#ROS> | 1.0E-5 s-1 | |||
(44) | DNA damage by basalROS | basalROS→damDNA+ basalROS | k dambasalROS <#basalROS> | 1.0E-9 s-1 |