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Figure 5 | Molecular Neurodegeneration

Figure 5

From: A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1

Figure 5

Dynein mutation increases potentially neuroprotective IGF-1. A- Spinal cord IGF-1 levels in wild type (+/+) and dynein mutant mice (Cra/+) bearing SOD1(G93A) transgene (SOD1m, black columns) or not (Wt, empty columns) #, p < 0.05 as indicated. Note that spinal cord IGF-1 levels are increased in dynein mutant mice and that this increase is stronger in compound SOD1(G93A)/Cra mice. N = 9 mice per group. B- mRNA levels of Insulin-like growth factor (IGF-1) in the spinal cord of wild type (+/+) and dynein mutant mice (Cra/+) bearing SOD1(G93A) transgene (SOD1m, black columns) or not (Wt, empty columns). N = 9 mice per group. C- mRNA levels of matrix metallo proteinase 9 (MMP9) in the spinal cord of wild type (+/+) and dynein mutant mice (Cra/+) bearing SOD1(G93A) transgene (SOD1m, black columns) or not (Wt, empty columns). *P < 0.05 versus Wt; #, p < 0.05 as indicated. N = 9 mice per group.

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Molecular Neurodegeneration

ISSN: 1750-1326