Figure 10

Schematic of PKCδ-PKD1 signal transduction mechanism during oxidative stress in dopaminergic neuronal cells. 1) Oxidative stress causes mitochondrial impairment; 2) activation of caspase cascade; 3) caspase-3 mediates proteolytic cleavage of PKCδ; 4) proteolytically cleaved PKCδ-catalytic fragment (CF) is active; 5) PKCδ-CF activates PKD1 by activation loop phosphorylation during the early stage of oxidative stress; 6) Fully active PKD1 regulates cell survival function in N27 dopaminergic cells.