Species | Age (M) | Disease Stage* | Gene | Expression, HD/Control | SEM | t-value | p-value |
---|
Mouse | 3 | Â | Casp2 | .704 | .063 | 1.78 | > 0.05 |
Mouse | 6 | Â | Casp2 | 1.15 | .11 | 0.56 | > 0.05 |
Mouse | 9 | Â | Casp2 | 1.20 | .12 | 0.71 | > 0.05 |
Mouse | 12 | Â | Casp2 | 1.01 | .12 | 0.08 | > 0.05 |
Human** | Â | 0-2 | Casp2 | 0.996 | Â | -0.14 | > 0.05 |
Human** | Â | 0-2 | HMGCR | 0.739 | Â | -5.04 | < 0.001 |
- Human striatal casp2 mRNA levels were extracted from publically available sources of microarray data (Affymetrix HG-U133A/B probe set 208050_s_at, HDBase.org-originally described in [66]). Mouse striatal casp2 levels were determined using QRT-PCR at 3, 6, 9 and 12 months of age. Casp2 is not upregulated in the striatum of aging YAC128 mice or human HD patients.
- * Vonsattel neuropathological score at time of death [3]
- ** Human data extracted from [40]