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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk

Figure 5

HMGCR exon 13 splicing efficiency is associated with the ratio of neuronal to glial markers. The percentage of HMGCRΔ13 in brain is significantly correlated with neuronal versus astrocyte enrichment in brain samples as determined by the ratio of synaptophysin: GFAP expression (p = 0.026, Pearson correlation = 0.339).

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Molecular Neurodegeneration

ISSN: 1750-1326