Table 2 B cell-related genes with significantly changed expression in PBL of PD-patients
From: Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease
Symbol | GenBank Accession No | Gene Name | B cells involvement |
|---|---|---|---|
A. Genes involved in B cell receptor signaling pathway | Â | ||
BLNK | NM_013314 | B-cell linker | B cell receptor signaling pathway (a); B cell activation (b), (g); B cell differentiation (b) |
CD19 | NM_001770 | CD19 antigen | B cell receptor signaling pathway (a); Expressed in B-cell (f), (g) |
CD22 | NM_001771 | CD22 antigen | B cell receptor signaling pathway (a); Expressed in B-cell (f), (g) |
CD72 | NM_001782 | CD72 antigen | B cell receptor signaling pathway (a); Expressed in B-cell (g) |
CD79A | NM_001783 | CD79A antigen (immunoglobulin-associated alpha) | B cell receptor signaling pathway (a),(b); B cell differentiation (b); B cell proliferation (b); B cell receptor complex (c) |
CD79B | NM_000626 | CD79B antigen (immunoglobulin-associated beta) | B cell receptor signaling pathway (a),(b); B cell receptor complex (c) |
CR2 | NM_001006658 | complement component (3d/epstein barr virus) receptor 2 | B cell receptor signaling pathway (a); B Lymphocyte Cell Surface Molecules (d) |
RASGRP3 | NM_170672 | ras guanyl releasing protein 3 (calcium and dag-regulated) | B cell receptor signaling pathway (a) |
B. Genes involved in other B cell-related annotations | Â | ||
BANK1 | NM_017935 | B-cell scaffold protein with ankyrin repeats 1 | B cell activation (b) |
CD40 | NM_001250 | CD40 antigen (tnf receptor superfamily member 5) | Positive regulation of B cell activation (b); Positive regulation of B cell proliferation (b); B cell mediated immunity (b) |
EBF1 | NM_024007 | early b-cell factor | B Cell Development (e) |
FCER2 | NM_002002 | FC fragment of ige, low affinity ii, receptor for (cd23a) | Expressed in B-cell (f), (g) |
IFNG | NM_000619 | interferon, gamma | Positive regulation of B cell activation (b); B cell mediated immunity (b) |
IGHD | BC021276 | immunoglobulin heavy constant delta | Expressed in primary B-Cells (f) |
IGHM | BC001872 | immunoglobulin heavy constant mu | Positive regulation of B cell proliferation B cell receptor signaling pathway (b); B cell receptor complex (c); B Cell Development; B cell activation (e); Expressed in primary B-Cells (f) |
IL1R2 | NM_004633 | interleukin 1 receptor, type ii | Expressed in B-cell (f) |
MSC | NM_005098 | musculin (activated b-cell factor-1) | Expressed in B-cell (f) |
SPIB | NM_003121 | spi-b transcription factor (spi-1/pu.1 related) | Expressed in B-cell (f) |
TCL1A | NM_021966 | T-cell leukemia/lymphoma 1a | Expressed in B-cell (f) |
C. Additional B cell-related genes | Â | ||
CD180 | NM_005582 | CD180 antigen | Expressed mainly on mature B cells (h); May be involved in the life/death decision of B-cells (j) |
CRISP3 | NM_006061 | cysteine-rich secretory protein 3 | Specifically expressed in pre-B cell [50] (i) |
FAM129C | NM_173544 | B-cell novel protein 1 | Specifically expressed in B-lymphocytes (k) |
FCRL1 | NM_052938 | FC receptor-like 1 | May serve as an activating coreceptor on B cells [51] (i) |
FCRL2 | NM_030764 | FC receptor-like 2 | Expression is limited to the mature B-cell lines (h); May have an regulatory role in normal and neoplastic B cell development (j) |
FCRLA | NM_032738 | FC receptor-like and mucin-like 1 | Specifically expressed in B-cells(k) |
NFE2L3 | NM_004289 | nuclear factor (erythroid-derived 2)-like 3 | Highly expressed in B-cell (h) |
MCOLN2 | NM_153259 | mucolipin 2 | Might play a role in B cell lysosomal function [25] (i) |
NT5E | NM_002526 | 5'-nucleotidase, ecto (CD73) | Mediates B cell adhesion [52] (i) |
PAX5 | NM_016734 | paired box gene 5 (b-cell lineage specific activator) | Key regulator of the B-cell-restricted expression of the CD23a isoforms [53] (i) |
TBK1 | NM_013254 | tank-binding kinase 1 | TBK1-mediated signaling in haematopoietic cells was critical for the induction of antigen-specific B and CD4(+) T cells [54] (i) |