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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Figure 6

UBP145 reverses the deleterious effect of late thrombolysis by tPA in an in vivo model of thrombotic stroke. Thrombotic stroke was induced in mice by injection of thrombin (1 UI.) into the middle cerebral artery. Late intravenous thrombolysis by tPA (10 mg/kg) alone or in combination with UBP145 (6.67 mg/kg) was performed 4 hours after MCA occlusion. The co-administration of UBP145 with tPA prevented the deleterious effects of late thrombolysis with tPA (*p < 0.05). Representative thionine-stained sections are shown for each condition.

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Molecular Neurodegeneration

ISSN: 1750-1326