Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

Table 1 Polymorphisms located in or near miRNA target sites located in the 3'UTR of hAPP

SNP ID	Position in 3'UTR	Polymorphism	Patient-specific	Predicted miRNA	Seed region
unknown	171	T/C	Y	hsa-miR-644	Y
				hsa-miR-147	N
				hsa-miR-323-3p	N
unknown	454	A/G	Y	hsa-miR-153	N
				hsa-miR-20a	N
				has-miR-17	N
				hsa-miR-106b	N
				hsa-miR-1245	Y
				hsa-miR-383	Y
rs3200120	833	A/C	unknown	hsa-miR-655	N
				hsa-miR-128	Y
				hsa-miR-199b-5p	Y
rs736479	914	G/A	Y	-	-
rs1059461	937	G/A	unknown	-	-
unknown	965	C/G	Y	-	-
rs45541739	967	G/A	unknown	-	-

The SNP ID, the nature of the polymorphism, as well as the patient specificity are indicated. The unknown SNP IDs can be found in Bettens et al. [20]. miRNAs which are predicted to interact with the 3'UTR of hAPP are listed, and it is noted when the SNP is located within the seed-region of the miRNA in question. Y = yes, N = no.

ISSN: 1750-1326