Mice Genotype | SNCA expression | Data quality control | Altered genes |
---|
 | species | fold change (mean ± sd) | source | % calls (present) | intensity (mean ± sd) | up | down | total |
---|
ASO
|
m
Snca
a
| 0.9 ± 0.1 |
All
c
| 57.5 | 197 ± 445 | 349 | 484 | 833 |
 |
h
SNCA
b
| 155 ± 85 |
D.E.G.
d
| 84.1 | 220 ± 271 | 96 | 137 | 233 |
wt
|
h
SNCA
| 1.1 ± 0.5 |
All
c
| 58.6 | 194 ± 425 | 0 | 0 | 0 |
 |
m
Snca
| 1.0 ± 0.0 |
D.E.G.
d
| 91.3 | 223 ± 295 | 0 | 0 | 0 |
- Abbreviations: ASO: α-Synuclein (SNCA) overexpressing; wt; wild type; D.E.G.: differentially expressed gene
- Notes: a- mSnca detected by 3 probe sets in theMoe-430A chip; b- hSNCA measured by qRT-PCR in 3 wt and 3 ASO mice (Figure 2B); c- Include all changed genes P < 0.005; d- Selection criteria for D.E.G. (1) gene is present in at least one of the mice groups examined and (2) Fold change > 1.52 (Signal log2 ratio > 0.6), p < 0.005.