Figure 4

Basal glutamatergic synaptic transmission in the ACC. (A) AMPA receptor-mediated mEPSCs recorded in the ACC neurons at a holding potential of −70 mV. Representative traces show the mEPSCs in slices treated with saline, DL-AP3 or/and SKF81297. (B) Cumulative frequency (left) and amplitude (right) histogram of the mEPSCs from the Fmr1 WT mice. (C) Summary of mEPSCs frequency (left) and amplitude (right) in neurons from the saline, DL-AP3 (10 μM, n = 7 slices/3 mice), SKF81297 (5 μM, n = 6 slices/3 mice), and DL-AP3 (10 μM) + SKF81297 (5 μM) (n = 7 slices/3 mice). (D) Cumulative frequency (left) and amplitude (right) histogram of the mEPSCs from the Fmr1 KO mice. (E) Summary of mEPSCs frequency (left) and amplitude (right) in neurons from the saline, DL-AP3 (10 μM, n = 6 slices/3 mice), SKF81297 (5 μM, n = 6 slices/3 mice), and DL-AP3 (10 μM) + SKF81297 (5 μM) (n = 7 slices/3 mice).