Transgene expression | Disease mechanism | TDP-43 |
---|
 | GF | LF | DN | Fly(a) | Fish(b) | Rod.(c) |
OE mutant | + |
-
| + | + | + | + |
OE WT | −/+ |
-
| −/+ | + | + | + |
KO or KD |
-
| + | + | + | + | ? |
- OE = overexpression; KO = knockout; KD = knockdown;
- GF = Gain of function; DN = Dominant negative; LF = Loss of function
- Rod. = rodents; + = positive for neurological phenotype
- - = negative for neurological phenotype; ? = remains to be determined
- See the text for detailed explanation and references for the models.
- (a) reference [30–34]; (b) reference [35]
- (c) reference [12, 23–27, 36–43]