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Table 4 Meta-analysis of rare CLU genetic variants.

From: Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

 

Total chromosome

number

Rare genetic variants

 
 

AD

C

AD (%)

C (%)

OR [95% CI]

Flanders-Belgian (this study)

1698

1318

21 (1.2)

9 (0.7)

1.82 [0.8-3.39]

Lille (this study)

2610

1220

21 (0.8)

3 (0.2)

3.29 [0.98-11.05]

Toronto (this study)

612

462

6 (1.0)

2 (0.4)

2.28 [0.46-11.33]

Portugal (Guerreiro et al.) 14

806

470

9 (1.1)

2 (0.4)

2.64 [0.57-12.28]

UK (Guerreiro et al.) 14

892

1264

2 (0.2)

2 (0.2)

1.42 [0.20-10.09]

US-Caucasian (Tycko et al.) 15

106

86

1 (0.9)

3 (3.5)

0.26 [0.03-2.58]

Summary

6724

4820

60 (0.9)

21 (0.4)

1.96 [1.18-3.25]

     

pMH = 0.009

     

pwoolf = 0.551

  1. Total allele counts and frequencies of rare non-synonymous substitutions affecting the CLU β-chain observed in AD patients and control individuals. P-values are given for fixed-effect Mantel-Haenszel test (pMH) and Woolf's test for heterogeneity (pwoolf). Odds ratios are given with 95% confidence intervals; summary odds ratio is based on a fixed-effect Mantel-Haenszel meta-analysis. Significant associations are depicted in bold. Compared to our p.R338W finding, Guerreiro and colleagues14 observed another non-synonymous substitution at codon 338 in 1 AD patient 5 (p.R338Q).
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Molecular Neurodegeneration

ISSN: 1750-1326