Table 1 Effect of increasing parameter values on model outputs for normal Aβ degradation rate (Model 2)
Parameter | Number of plaques (%) | Plaque size | Lag time |
|---|---|---|---|
k dimer | Increases to max of 100 | No effect | Decreases |
k dedimer | Decreases | No effect | Increases |
k pf | Increases to max of ~50 | No effect | No effect |
k pg | Small effect | Increases | No effect |
k pghalf | Small effect | No effect | Slight decrease for large values |
k disagg | No effect | Decreases | Increase at high values |
k degNep | Increases | Increases | Decreases |