Figure 2

Structures of RNA binding proteins. A) RNA binding proteins, such as TIA-1, TDP-43 and FUS, contain RNA-recognition motifs (RRM), which bind RNA and Glycine rich (Gly-rich) domains that mediate protein aggregation. TDP-43 and FUS contain discrete nuclear localization and nuclear export signals (NLS, NES), while nuclear localization of TIA-1 does not appear to localize to particular domains [11, 12]. B) Alignment of glycine rich domains of TIA-1, TIAR and Sup-35. The alignment was performed using the “multalin” program (http://multalin.toulouse.inra.fr). In the consensus sequence, the red letters correspond to homologous amino acids, where the # symbol is used to convey imperfect homologies, and the blue letters refer to partial homology.