Table 1 Gene ontology clusters in the mouse retina upregulated at various time points after I/R injury
Time |  | Ontology | Enrichment score | P value (P < 0.05) |
|---|---|---|---|---|
0 day | Â | No significant changes | Â | Â |
6 hr | BP | eye development | 4.82 | 3.20E-04 |
inflammatory response | 4.49 | 2.20E-05 | ||
apoptosis | 1.76 | 8.40E-03 | ||
blood Bessel morphogenesis | 0.67 | 4.00E-02 | ||
MF | structural constituent of eye lens | 4.82 | 7.80E-09 | |
cytokine activity | 3.15 | 3.80E-04 | ||
CC | extracellular space | 3.15 | 1.80E-04 | |
1 day | BP | eye development | 8.99 | 2.10E-09 |
inflammatory response | 3.51 | 2.20E-03 | ||
cell death | 1.37 | 1.10E-02 | ||
MF | structural constituent of eye lens | 8.99 | 1.80E-15 | |
transcriptional factor activity | 1.52 | 1.80E-02 | ||
CC | extracellular region part | 2.71 | 1.30E-05 | |
3 day | BP | inflammatory response | 8.12 | 3.30E-08 |
eye development | 5.29 | 1.30E-04 | ||
cell death | 2.21 | 9.60E-04 | ||
MF | structural molecule activity | 5.29 | 3.30E-04 | |
CC | extracellular region | 3.1 | 5.30E-04 | |
7 day | BP | defense response | 2.83 | 7.00E-09 |
eye development | 1.59 | 2.10E-02 | ||
MF | peptide antigen binding | 2.83 | 1.20E-02 | |
CC | extracellular region part | 3.62 | 1.90E-04 | |
antigen processing and presentation | 2.83 | 1.60E-03 | ||
14 day | BP | chemotaxis | 3.2 | 3.90E-03 |
cell-cell signaling | 2.51 | 1.90E-03 | ||
inflammatory response | 1.96 | 6.50E-02 | ||
cell death | 1.73 | 3.40E-03 | ||
tissue regeneration | 1.51 | 5.60E-03 | ||
myelination | 1.51 | 4.90E-02 | ||
neuron differentiation | 1.35 | 3.80E-02 | ||
MF | glutamate receptor activity | 3.13 | 4.80E-04 | |
CC | extracellular region | 6.58 | 6.60E-04 | |
neuron projection | 4.31 | 3.30E-06 | ||
synapse | 3.13 | 1.20E-05 | ||
postsynaptic membrane | 3.13 | 2.80E-03 | ||
gap junction | 1.64 | 3.60E-02 | ||
21 day | BP | defense response | 1.73 | 1.10E-02 |
inflammatory response | 1.73 | 3.00E-02 | ||
hemopoiesis | 1.3 | 4.00E-02 | ||
MF | no significant changes | Â | Â | |
CC | extracellular region part | 4.57 | 1.60E-07 | |
extracellular region | 4.57 | 1.50E-06 | ||
proteinaceous extracellular matrix | 1.56 | 2.10E-04 | ||
28 day | BP | immune response | 2.46 | 2.20E-04 |
protein maturation | 2.46 | 4.50E-02 | ||
complement activation | 2.46 | 7.10E-03 | ||
MF | glycosaminoglycan binding | 1.02 | 5.70E-02 | |
CC | extracellular region | 3.48 | 3.90E-04 | |
proteinaceous extracellular matrix | 1.36 | 3.70E-03 |