From: HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
HDAC6 catalytic pocket (CDII) | HDAC6 ubiquitin binding domain (ZnFUBP) | |||
---|---|---|---|---|
Inhibitor stabilization | Catalytic channel rim (cap domain) | His 499 | Ubiquitin stabilization | Â |
Pro 501 | ||||
Leu 749 | ||||
Phe 679 | ||||
Asp 567 | ||||
Ser 498 | ||||
His 500 | ||||
Glu 502 | Arg 1155 ** | |||
Val 503 | Tyr 1156 ** | |||
Phe 566 | Tyr 1184 | |||
 | Met 682 | Trp 1143 | ||
Internal cavity ZBG + linker domain | Zinc | Tyr 1189 | ||
Asp 649* | Trp 1182 | |||
Asp 742* | Â | |||
His 610 | ||||
His 611 | ||||
Pro 608 | ||||
Phe 620 | ||||
Cys 621 | ||||
Tyr 782 | ||||
Phe 680+ | ||||
 |  | Phe 620+ |  |  |