From: The transcription factor X-box binding protein-1 in neurodegenerative diseases
Pathologies | Evidence | References |
---|---|---|
Metabolic disorders | ||
- Diabetes | XBP-1 influences glucose homeostasis | |
- Non-alcoholic fatty liver disease | XBP-1/PDI/MTP axis activation | [25] |
TLR4 dependent XBP-1 activation by HFHC diet | [26] | |
Inflammatory diseases | ||
- Rheumatoid arthritis | XBP-1 upregulation | [27] |
- Inflammatory bowel disease | XBP-1 gene single-nucleotide polymorphisms | [28] |
Cancers | ||
- Lymphoid malignancies | XBP-1 inhibition reduces leukemic progression | [29] |
- Breast cancers | Activation of UPR and upregulation of XBP-1 | |
- Colorectal cancers | XBP-1 overexpression in adenomas and adenocarcinomas | [33] |
Neurodegenerative diseases | ||
- Huntington’s disease | XBP-1 invalidation protects over HD | [34] |
- Alzheimer’s disease | XBP-1 overexpression in AD patients | |
XBP-1 polymorphism associated to AD risk | [38] | |
- Parkinson’s disease | Implication of IRE1-XBP-1 in dopaminergic neurons survival | |
- Amyotrophic lateral sclerosis | Increase in XBP-1 splicing in ALS models |