Fig. 2
From: Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease
Ablation of microglia by DT administration has no effect on the number of amyloid plaques. a. Timeline of tamoxifen administration, DT administration and in vivo imaging of Congo Red-labeled plaques. Time-lapse imaging was performed 1 day after (D13), 1 week after (D20) and 2 weeks after DT administration (D27). b. Images of the same ROIs in APP/PS1 mice over 1–2 weeks. c. Quantification of plaque density in APP/PS1 mice in each ROI. d. Images of the same ROIs in APP/PS1/CX 3 CR1-iDTR mice over 1–2 weeks. Neither elimination of existing Aβ plaques nor formation of new plaques occurred in APP/PS1 or APP/PS1/CX 3 CR1-iDTR mice. e. Quantification of plaque density in APP/PS1/CX 3 CR1-iDTR mice in each ROI