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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

Fig. 5

Tau accumulates in RGC intraretinal axons. a-f Whole-mounted retinas labeled with tau (K9JA) and the axonal marker NF-H revealed marked accumulation of tau in intraretinal axons of young (3 months) transgenic mice relative to controls. g-l Tau build up in intraretinal axons, visualized with NF-H, was more pronounced at 6 months of age. m Real-time qPCR analysis demonstrated no significant change in retinal tau gene expression (3xTg: n = 7, WT: n = 7, Student’s t-test, n.s.: not significant p > 0.05). Scale bars: a–l = 50 μm

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Molecular Neurodegeneration

ISSN: 1750-1326