Table 1 mtDNA changes in AD
From: Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances
Mutation type | Affected mtDNA region | Analysis Method | Changes in AD | Reference |
|---|---|---|---|---|
mtDNA Δ4977 | I, III and V | PCR | Increased | Corral-Debrinski et al. [80] |
mtDNA Δ4977 | I, III and V | PCR | No changes | Blanchard et al. [79] |
mtDNA Δ4977 | I, III and V | In situ hybridization | Increased | Hirai et al. [87] |
mtDNA Δ4977 | I, III and V | PCR | No changes | Bender et al. [90] |
mtDNA Δ4977 | I, III and V | PCR | Increased | Krishnan et al. [88] |
mtDNA Δ4977 | I, III and V | Realtime PCR | No changes | Strobel et al. [89] |
DNA Rearrangement | Mitochondrial genome | Next generation sequencing | Increased | Chen et al. [81] |
Point mutation | D-loop region | PCR/Sanger sequencing | Increased | Coskun et al. [82] |
Point mutation | Mitochondrial genome | Random mutation capture | No changes | Soltys et al. [83] |
Point mutation | Mitochondrial genome | PCR-cloning-sequencing | Increased | Lin et al. [84] |
Point mutation | Mitochondrial genome | Next generation sequencing | Increased | Hoekstra et al. [91] |
DNA methylation | D-loop region | TaqMan PCR | Increased | Blanch et al. [96] |
DNA methylation | D-loop region | Realtime PCR | Decreased | Stoccoro et al. [97] |