Fig. 8From: The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microgliaModel for the function of hCD33 isoforms in modulating phagocytosis. a hCD33M represses phagocytosis from the cell surface through its cytoplasmic ITIM motif. b hCD33m is located within an intracellular compartment and augments phagocytosis through transcriptional skewingBack to article page